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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Nuclear casein kinase and cyclin dependent kinase substrate 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q32.1
Chromosome location (bp)
205712822 - 205750182
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) 1. Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 2....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA repair
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0001678[cellular glucose homeostasis] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0003697[single-stranded DNA binding] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006275[regulation of DNA replication] GO:0006281[DNA repair] GO:0006325[chromatin organization] GO:0006974[cellular response to DNA damage stimulus] GO:0031297[replication fork processing] GO:0035822[gene conversion] GO:0036297[interstrand cross-link repair] GO:0042593[glucose homeostasis] GO:0043923[positive regulation by host of viral transcription] GO:0044827[modulation by host of viral genome replication] GO:0044829[positive regulation by host of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046626[regulation of insulin receptor signaling pathway] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0060382[regulation of DNA strand elongation] GO:0071481[cellular response to X-ray] GO:0140297[DNA-binding transcription factor binding] GO:1990968[modulation by host of RNA binding by virus] GO:1990969[modulation by host of viral RNA-binding transcription factor activity]
The Human Protein Atlas project is funded
