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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
FDA approved drug targets Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.2
Chromosome location (bp)
51942345 - 51948867
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage 1,2,3,4,5,6,7,8,9. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins 10,11. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation 12. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 13,14. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks 15,16,17. Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA 18. Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ 19. Suppresses G-quadruplex (G4) structures in response to DNA damage 20. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks 21,22,23. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) 24. May link the DNA damage surveillance network to the mitotic fidelity checkpoint 25. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks 26,27....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA repair
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NAD
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000723[telomere maintenance] GO:0003824[catalytic activity] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005814[centriole] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0030592[DNA ADP-ribosylation] GO:0035861[site of double-strand break] GO:0045171[intercellular bridge] GO:0045829[negative regulation of isotype switching] GO:0051106[positive regulation of DNA ligation] GO:0060236[regulation of mitotic spindle organization] GO:0070213[protein auto-ADP-ribosylation] GO:0140294[NAD DNA ADP-ribosyltransferase activity] GO:0140804[NAD+- protein-lysine ADP-ribosyltransferase activity] GO:0140806[NAD+- protein-aspartate ADP-ribosyltransferase activity] GO:0140807[NAD+-protein-glutamate ADP-ribosyltransferase activity] GO:1905662[negative regulation of telomerase RNA reverse transcriptase activity] GO:1990166[protein localization to site of double-strand break] GO:1990404[NAD+-protein ADP-ribosyltransferase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
Metabolic proteins Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000723[telomere maintenance] GO:0003824[catalytic activity] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005814[centriole] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0030592[DNA ADP-ribosylation] GO:0035861[site of double-strand break] GO:0045171[intercellular bridge] GO:0045829[negative regulation of isotype switching] GO:0051106[positive regulation of DNA ligation] GO:0060236[regulation of mitotic spindle organization] GO:0070213[protein auto-ADP-ribosylation] GO:0140294[NAD DNA ADP-ribosyltransferase activity] GO:0140804[NAD+- protein-lysine ADP-ribosyltransferase activity] GO:0140806[NAD+- protein-aspartate ADP-ribosyltransferase activity] GO:0140807[NAD+-protein-glutamate ADP-ribosyltransferase activity] GO:1905662[negative regulation of telomerase RNA reverse transcriptase activity] GO:1990166[protein localization to site of double-strand break] GO:1990404[NAD+-protein ADP-ribosyltransferase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
Metabolic proteins Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000723[telomere maintenance] GO:0003824[catalytic activity] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005814[centriole] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0030592[DNA ADP-ribosylation] GO:0035861[site of double-strand break] GO:0045171[intercellular bridge] GO:0045829[negative regulation of isotype switching] GO:0051106[positive regulation of DNA ligation] GO:0060236[regulation of mitotic spindle organization] GO:0070213[protein auto-ADP-ribosylation] GO:0140294[NAD DNA ADP-ribosyltransferase activity] GO:0140804[NAD+- protein-lysine ADP-ribosyltransferase activity] GO:0140806[NAD+- protein-aspartate ADP-ribosyltransferase activity] GO:0140807[NAD+-protein-glutamate ADP-ribosyltransferase activity] GO:1905662[negative regulation of telomerase RNA reverse transcriptase activity] GO:1990166[protein localization to site of double-strand break] GO:1990404[NAD+-protein ADP-ribosyltransferase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
Metabolic proteins Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000723[telomere maintenance] GO:0003824[catalytic activity] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005814[centriole] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0030592[DNA ADP-ribosylation] GO:0035861[site of double-strand break] GO:0045171[intercellular bridge] GO:0045829[negative regulation of isotype switching] GO:0051106[positive regulation of DNA ligation] GO:0060236[regulation of mitotic spindle organization] GO:0070213[protein auto-ADP-ribosylation] GO:0140294[NAD DNA ADP-ribosyltransferase activity] GO:0140804[NAD+- protein-lysine ADP-ribosyltransferase activity] GO:0140806[NAD+- protein-aspartate ADP-ribosyltransferase activity] GO:0140807[NAD+-protein-glutamate ADP-ribosyltransferase activity] GO:1905662[negative regulation of telomerase RNA reverse transcriptase activity] GO:1990166[protein localization to site of double-strand break] GO:1990404[NAD+-protein ADP-ribosyltransferase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
Metabolic proteins Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000723[telomere maintenance] GO:0003824[catalytic activity] GO:0003950[NAD+ ADP-ribosyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005814[centriole] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016757[glycosyltransferase activity] GO:0016779[nucleotidyltransferase activity] GO:0030592[DNA ADP-ribosylation] GO:0035861[site of double-strand break] GO:0045171[intercellular bridge] GO:0045829[negative regulation of isotype switching] GO:0051106[positive regulation of DNA ligation] GO:0060236[regulation of mitotic spindle organization] GO:0070213[protein auto-ADP-ribosylation] GO:0140294[NAD DNA ADP-ribosyltransferase activity] GO:0140804[NAD+- protein-lysine ADP-ribosyltransferase activity] GO:0140806[NAD+- protein-aspartate ADP-ribosyltransferase activity] GO:0140807[NAD+-protein-glutamate ADP-ribosyltransferase activity] GO:1905662[negative regulation of telomerase RNA reverse transcriptase activity] GO:1990166[protein localization to site of double-strand break] GO:1990404[NAD+-protein ADP-ribosyltransferase activity] GO:2001034[positive regulation of double-strand break repair via nonhomologous end joining]
The Human Protein Atlas project is funded
