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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q33.1
Chromosome location (bp)
150401637 - 150412969
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P04233 [Direct mapping] HLA class II histocompatibility antigen gamma chain Class-II-associated invariant chain peptide
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CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0001516[prostaglandin biosynthetic process] GO:0001540[amyloid-beta binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001961[positive regulation of cytokine-mediated signaling pathway] GO:0002250[adaptive immune response] GO:0002286[T cell activation involved in immune response] GO:0002376[immune system process] GO:0002606[positive regulation of dendritic cell antigen processing and presentation] GO:0002792[negative regulation of peptide secretion] GO:0002830[positive regulation of type 2 immune response] GO:0002906[negative regulation of mature B cell apoptotic process] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005770[late endosome] GO:0005771[multivesicular body] GO:0005773[vacuole] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006886[intracellular protein transport] GO:0006952[defense response] GO:0006955[immune response] GO:0008283[cell population proliferation] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016064[immunoglobulin mediated immune response] GO:0019882[antigen processing and presentation] GO:0019883[antigen processing and presentation of endogenous antigen] GO:0019886[antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019955[cytokine binding] GO:0023026[MHC class II protein complex binding] GO:0030336[negative regulation of cell migration] GO:0030658[transport vesicle membrane] GO:0030666[endocytic vesicle membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030890[positive regulation of B cell proliferation] GO:0031394[positive regulation of prostaglandin biosynthetic process] GO:0032588[trans-Golgi network membrane] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032991[protein-containing complex] GO:0033674[positive regulation of kinase activity] GO:0034341[response to type II interferon] GO:0035691[macrophage migration inhibitory factor signaling pathway] GO:0035692[macrophage migration inhibitory factor receptor complex] GO:0035693[NOS2-CD74 complex] GO:0035718[macrophage migration inhibitory factor binding] GO:0042289[MHC class II protein binding] GO:0042609[CD4 receptor binding] GO:0042613[MHC class II protein complex] GO:0042658[MHC class II protein binding, via antigen binding groove] GO:0042802[identical protein binding] GO:0043030[regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043202[lysosomal lumen] GO:0043410[positive regulation of MAPK cascade] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044183[protein folding chaperone] GO:0045058[T cell selection] GO:0045059[positive thymic T cell selection] GO:0045060[negative thymic T cell selection] GO:0045581[negative regulation of T cell differentiation] GO:0045582[positive regulation of T cell differentiation] GO:0045657[positive regulation of monocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046598[positive regulation of viral entry into host cell] GO:0048146[positive regulation of fibroblast proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0050998[nitric-oxide synthase binding] GO:0051085[chaperone cofactor-dependent protein refolding] GO:0060907[positive regulation of macrophage cytokine production] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0070206[protein trimerization] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090023[positive regulation of neutrophil chemotaxis] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production] GO:2000448[positive regulation of macrophage migration inhibitory factor signaling pathway]
P04233 [Direct mapping] HLA class II histocompatibility antigen gamma chain Class-II-associated invariant chain peptide
Show all
CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000139[Golgi membrane] GO:0001516[prostaglandin biosynthetic process] GO:0001540[amyloid-beta binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001961[positive regulation of cytokine-mediated signaling pathway] GO:0002250[adaptive immune response] GO:0002286[T cell activation involved in immune response] GO:0002376[immune system process] GO:0002792[negative regulation of peptide secretion] GO:0002830[positive regulation of type 2 immune response] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005770[late endosome] GO:0005773[vacuole] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006886[intracellular protein transport] GO:0006955[immune response] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016064[immunoglobulin mediated immune response] GO:0019882[antigen processing and presentation] GO:0019883[antigen processing and presentation of endogenous antigen] GO:0019955[cytokine binding] GO:0023026[MHC class II protein complex binding] GO:0030336[negative regulation of cell migration] GO:0030658[transport vesicle membrane] GO:0030666[endocytic vesicle membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030890[positive regulation of B cell proliferation] GO:0031394[positive regulation of prostaglandin biosynthetic process] GO:0032588[trans-Golgi network membrane] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032991[protein-containing complex] GO:0033674[positive regulation of kinase activity] GO:0034341[response to type II interferon] GO:0035692[macrophage migration inhibitory factor receptor complex] GO:0035718[macrophage migration inhibitory factor binding] GO:0042289[MHC class II protein binding] GO:0042609[CD4 receptor binding] GO:0042613[MHC class II protein complex] GO:0042658[MHC class II protein binding, via antigen binding groove] GO:0042802[identical protein binding] GO:0043030[regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043202[lysosomal lumen] GO:0043410[positive regulation of MAPK cascade] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044183[protein folding chaperone] GO:0045058[T cell selection] GO:0045657[positive regulation of monocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046598[positive regulation of viral entry into host cell] GO:0048146[positive regulation of fibroblast proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0060907[positive regulation of macrophage cytokine production] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0070206[protein trimerization] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090023[positive regulation of neutrophil chemotaxis] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production] GO:2000448[positive regulation of macrophage migration inhibitory factor signaling pathway]
P04233 [Direct mapping] HLA class II histocompatibility antigen gamma chain Class-II-associated invariant chain peptide
Show all
CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000139[Golgi membrane] GO:0001516[prostaglandin biosynthetic process] GO:0001540[amyloid-beta binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001961[positive regulation of cytokine-mediated signaling pathway] GO:0002250[adaptive immune response] GO:0002286[T cell activation involved in immune response] GO:0002376[immune system process] GO:0002792[negative regulation of peptide secretion] GO:0002830[positive regulation of type 2 immune response] GO:0004896[cytokine receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005770[late endosome] GO:0005773[vacuole] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006886[intracellular protein transport] GO:0006955[immune response] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016064[immunoglobulin mediated immune response] GO:0019882[antigen processing and presentation] GO:0019883[antigen processing and presentation of endogenous antigen] GO:0019955[cytokine binding] GO:0023026[MHC class II protein complex binding] GO:0030336[negative regulation of cell migration] GO:0030658[transport vesicle membrane] GO:0030666[endocytic vesicle membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030890[positive regulation of B cell proliferation] GO:0031394[positive regulation of prostaglandin biosynthetic process] GO:0032588[trans-Golgi network membrane] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032991[protein-containing complex] GO:0033674[positive regulation of kinase activity] GO:0034341[response to type II interferon] GO:0035692[macrophage migration inhibitory factor receptor complex] GO:0035718[macrophage migration inhibitory factor binding] GO:0042289[MHC class II protein binding] GO:0042609[CD4 receptor binding] GO:0042613[MHC class II protein complex] GO:0042658[MHC class II protein binding, via antigen binding groove] GO:0042802[identical protein binding] GO:0043030[regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043202[lysosomal lumen] GO:0043410[positive regulation of MAPK cascade] GO:0043518[negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044183[protein folding chaperone] GO:0045058[T cell selection] GO:0045657[positive regulation of monocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046598[positive regulation of viral entry into host cell] GO:0048146[positive regulation of fibroblast proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0060907[positive regulation of macrophage cytokine production] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0070206[protein trimerization] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090023[positive regulation of neutrophil chemotaxis] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production] GO:2000448[positive regulation of macrophage migration inhibitory factor signaling pathway]