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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
p11.22
Chromosome location (bp)
9475009 - 9538114
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multifunctional protein that functions as a downstream effector of RALA and RALB 1. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity 2. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis 3,4. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle 5. During mitosis, also controls mitochondrial fission as an effector of RALA 6. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation, Translocase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Metabolic proteins Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000922[spindle pole] GO:0001934[positive regulation of protein phosphorylation] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006897[endocytosis] GO:0006935[chemotaxis] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008559[ABC-type xenobiotic transporter activity] GO:0015431[ABC-type glutathione S-conjugate transporter activity] GO:0016020[membrane] GO:0022857[transmembrane transporter activity] GO:0031267[small GTPase binding] GO:0032489[regulation of Cdc42 protein signal transduction] GO:0042626[ATPase-coupled transmembrane transporter activity] GO:0042910[xenobiotic transmembrane transporter activity] GO:0043087[regulation of GTPase activity] GO:0043547[positive regulation of GTPase activity] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0055085[transmembrane transport] GO:0090141[positive regulation of mitochondrial fission] GO:1900753[doxorubicin transport] GO:1990961[xenobiotic detoxification by transmembrane export across the plasma membrane]
Enzymes ENZYME proteins Metabolic proteins Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000922[spindle pole] GO:0001934[positive regulation of protein phosphorylation] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006897[endocytosis] GO:0006935[chemotaxis] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0008559[ABC-type xenobiotic transporter activity] GO:0015431[ABC-type glutathione S-conjugate transporter activity] GO:0016020[membrane] GO:0022857[transmembrane transporter activity] GO:0031267[small GTPase binding] GO:0032489[regulation of Cdc42 protein signal transduction] GO:0042626[ATPase-coupled transmembrane transporter activity] GO:0042910[xenobiotic transmembrane transporter activity] GO:0043087[regulation of GTPase activity] GO:0043547[positive regulation of GTPase activity] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0055085[transmembrane transport] GO:0090141[positive regulation of mitochondrial fission] GO:1900753[doxorubicin transport] GO:1990961[xenobiotic detoxification by transmembrane export across the plasma membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
A0A1W2PRI7 [Direct mapping] RalA-binding protein 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
