GENERAL INFORMATIONi
Gene namei BID
Synonyms
Gene descriptioni BH3 interacting domain death agonist
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 22
Cytoband q11.21
Chromosome location (bp) 17734138 - 17774770
Number of transcriptsi 7
Ensembl ENSG00000015475 (version 109)
Entrez gene 637
HGNC HGNC:1050
UniProt P55957 (UniProt - Evidence at protein level)
neXtProt NX_P55957
GeneCards BID
Antibodypedia BID antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Induces caspases and apoptosis 1. Counters the protective effect of BCL2 (By similarity).
Biological process (UniProt)i Apoptosis
Gene summary (Entrez)i This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
BID-201
ENSP00000318822
ENST00000317361
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097284 [hepatocyte apoptotic process]
GO:0097435 [supramolecular fiber organization]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 241 aa
26.8 kDa 		No 0
BID-202
ENSP00000344594
ENST00000342111
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097284 [hepatocyte apoptotic process]
GO:0097435 [supramolecular fiber organization]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 137 aa
14.6 kDa 		No 0
BID-203
ENSP00000382667
ENST00000399765
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
B2ZP79
[Target identity:100%; Query identity:100%] BH3-interacting domain death agonist
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097284 [hepatocyte apoptotic process]
GO:0097435 [supramolecular fiber organization]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-204
ENSP00000382669
ENST00000399767
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
B2ZP79
[Target identity:100%; Query identity:100%] BH3-interacting domain death agonist
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097284 [hepatocyte apoptotic process]
GO:0097435 [supramolecular fiber organization]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-208
ENSP00000449236
ENST00000551952
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
A8ASI8
[Target identity:100%; Query identity:100%] BH3-interacting domain death agonist
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097284 [hepatocyte apoptotic process]
GO:0097435 [supramolecular fiber organization]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 195 aa
22 kDa 		No 0
BID-210
ENSP00000477773
ENST00000614949
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
B2ZP79
[Target identity:100%; Query identity:100%] BH3-interacting domain death agonist
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0051402 [neuron apoptotic process]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097284 [hepatocyte apoptotic process]
GO:0097435 [supramolecular fiber organization]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 99 aa
11.3 kDa 		No 0
BID-211
ENSP00000480414
ENST00000622694
P55957
[Direct mapping] BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11
Show all
A8ASI8
[Target identity:100%; Query identity:100%] BH3-interacting domain death agonist
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006626 [protein targeting to mitochondrion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008637 [apoptotic mitochondrial changes]
GO:0010918 [positive regulation of mitochondrial membrane potential]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031966 [mitochondrial membrane]
GO:0042129 [regulation of T cell proliferation]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042775 [mitochondrial ATP synthesis coupled electron transport]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0051402 [neuron apoptotic process]
GO:0065003 [protein-containing complex assembly]
GO:0090150 [establishment of protein localization to membrane]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
GO:0097345 [mitochondrial outer membrane permeabilization]
GO:0097435 [supramolecular fiber organization]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 195 aa
22 kDa 		No 0

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