GENERAL INFORMATIONi
Gene namei PAFAH1B1
Synonyms LIS1, MDCR, MDS, NudF, PAFAH
Gene descriptioni Platelet activating factor acetylhydrolase 1b regulatory subunit 1
Protein classi Disease related genes
Human disease related genes
Metabolic proteins
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband p13.3
Chromosome location (bp) 2593210 - 2685615
Number of transcriptsi 11
Ensembl ENSG00000007168 (version 109)
Entrez gene 5048
HGNC HGNC:8574
UniProt P43034 (UniProt - Evidence at protein level)
neXtProt NX_P43034
GeneCards PAFAH1B1
Antibodypedia PAFAH1B1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos 1. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). show less
Molecular function (UniProt)i Developmental protein
Biological process (UniProt)i Cell cycle, Cell division, Differentiation, Lipid degradation, Lipid metabolism, Mitosis, Neurogenesis, Transport
Gene summary (Entrez)i This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PAFAH1B1-202
ENSP00000380378
ENST00000397195
P43034
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000235 [astral microtubule]
GO:0000776 [kinetochore]
GO:0001667 [ameboidal-type cell migration]
GO:0001675 [acrosome assembly]
GO:0001764 [neuron migration]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005938 [cell cortex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007254 [JNK cascade]
GO:0007268 [chemical synaptic transmission]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007420 [brain development]
GO:0007611 [learning or memory]
GO:0008017 [microtubule binding]
GO:0008090 [retrograde axonal transport]
GO:0008201 [heparin binding]
GO:0008247 [1-alkyl-2-acetylglycerophosphocholine esterase complex]
GO:0008344 [adult locomotory behavior]
GO:0009306 [protein secretion]
GO:0010977 [negative regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0016477 [cell migration]
GO:0017145 [stem cell division]
GO:0019226 [transmission of nerve impulse]
GO:0021540 [corpus callosum morphogenesis]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0021987 [cerebral cortex development]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031023 [microtubule organizing center organization]
GO:0031252 [cell leading edge]
GO:0031514 [motile cilium]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0034452 [dynactin binding]
GO:0036035 [osteoclast development]
GO:0038026 [reelin-mediated signaling pathway]
GO:0040019 [positive regulation of embryonic development]
GO:0042249 [establishment of planar polarity of embryonic epithelium]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043087 [regulation of GTPase activity]
GO:0043274 [phospholipase binding]
GO:0043622 [cortical microtubule organization]
GO:0044877 [protein-containing complex binding]
GO:0045505 [dynein intermediate chain binding]
GO:0045773 [positive regulation of axon extension]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046329 [negative regulation of JNK cascade]
GO:0046469 [platelet activating factor metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047496 [vesicle transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048854 [brain morphogenesis]
GO:0050804 [modulation of chemical synaptic transmission]
GO:0050885 [neuromuscular process controlling balance]
GO:0051010 [microtubule plus-end binding]
GO:0051012 [microtubule sliding]
GO:0051081 [nuclear membrane disassembly]
GO:0051130 [positive regulation of cellular component organization]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0051649 [establishment of localization in cell]
GO:0051660 [establishment of centrosome localization]
GO:0051661 [maintenance of centrosome location]
GO:0060117 [auditory receptor cell development]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070840 [dynein complex binding]
GO:0090102 [cochlea development]
GO:0090176 [microtubule cytoskeleton organization involved in establishment of planar polarity]
GO:0090724 [central region of growth cone]
GO:0097529 [myeloid leukocyte migration]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:0098978 [glutamatergic synapse]
GO:0099175 [regulation of postsynapse organization]
GO:0140650 [radial glia-guided pyramidal neuron migration]
GO:1904115 [axon cytoplasm]
GO:1904936 [interneuron migration]
Show all
 410 aa
46.6 kDa 		No 0
PAFAH1B1-208
ENSP00000460591
ENST00000574468
I3L3N5
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 208 aa
23.7 kDa 		No 0
PAFAH1B1-211
ENSP00000461087
ENST00000576586
I3L495
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 82 aa
9.6 kDa 		No 0
PAFAH1B1-214
ENSP00000501976
ENST00000674608
A0A6Q8PFU3
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit alpha
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0030154 [cell differentiation]
GO:0031965 [nuclear membrane]
GO:0051012 [microtubule sliding]
GO:0051301 [cell division]
GO:0070840 [dynein complex binding]
Show all
 428 aa
48.8 kDa 		No 0
PAFAH1B1-215
ENSP00000501931
ENST00000674717
A0A6Q8PFT2
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0007049 [cell cycle]
GO:0007399 [nervous system development]
GO:0016042 [lipid catabolic process]
GO:0030154 [cell differentiation]
GO:0051301 [cell division]
Show all
 345 aa
38.9 kDa 		No 0
PAFAH1B1-217
ENSP00000502843
ENST00000675202
P43034
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000235 [astral microtubule]
GO:0000776 [kinetochore]
GO:0001675 [acrosome assembly]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005938 [cell cortex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007268 [chemical synaptic transmission]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007611 [learning or memory]
GO:0008017 [microtubule binding]
GO:0008090 [retrograde axonal transport]
GO:0008201 [heparin binding]
GO:0008247 [1-alkyl-2-acetylglycerophosphocholine esterase complex]
GO:0008344 [adult locomotory behavior]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0019226 [transmission of nerve impulse]
GO:0021540 [corpus callosum morphogenesis]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0031023 [microtubule organizing center organization]
GO:0031252 [cell leading edge]
GO:0031514 [motile cilium]
GO:0031965 [nuclear membrane]
GO:0034452 [dynactin binding]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043274 [phospholipase binding]
GO:0046469 [platelet activating factor metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047496 [vesicle transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048854 [brain morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051010 [microtubule plus-end binding]
GO:0051012 [microtubule sliding]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070840 [dynein complex binding]
GO:1904115 [axon cytoplasm]
Show all
 410 aa
46.6 kDa 		No 0
PAFAH1B1-218
ENSP00000502031
ENST00000675331
P43034
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000235 [astral microtubule]
GO:0000776 [kinetochore]
GO:0001675 [acrosome assembly]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005938 [cell cortex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007268 [chemical synaptic transmission]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007611 [learning or memory]
GO:0008017 [microtubule binding]
GO:0008090 [retrograde axonal transport]
GO:0008201 [heparin binding]
GO:0008247 [1-alkyl-2-acetylglycerophosphocholine esterase complex]
GO:0008344 [adult locomotory behavior]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0019226 [transmission of nerve impulse]
GO:0021540 [corpus callosum morphogenesis]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0031023 [microtubule organizing center organization]
GO:0031252 [cell leading edge]
GO:0031514 [motile cilium]
GO:0031965 [nuclear membrane]
GO:0034452 [dynactin binding]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043274 [phospholipase binding]
GO:0046469 [platelet activating factor metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047496 [vesicle transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048854 [brain morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051010 [microtubule plus-end binding]
GO:0051012 [microtubule sliding]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070840 [dynein complex binding]
GO:1904115 [axon cytoplasm]
Show all
 410 aa
46.6 kDa 		No 0
PAFAH1B1-220
ENSP00000501969
ENST00000675390
P43034
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000235 [astral microtubule]
GO:0000776 [kinetochore]
GO:0001675 [acrosome assembly]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005938 [cell cortex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007268 [chemical synaptic transmission]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007611 [learning or memory]
GO:0008017 [microtubule binding]
GO:0008090 [retrograde axonal transport]
GO:0008201 [heparin binding]
GO:0008247 [1-alkyl-2-acetylglycerophosphocholine esterase complex]
GO:0008344 [adult locomotory behavior]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0019226 [transmission of nerve impulse]
GO:0021540 [corpus callosum morphogenesis]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0031023 [microtubule organizing center organization]
GO:0031252 [cell leading edge]
GO:0031514 [motile cilium]
GO:0031965 [nuclear membrane]
GO:0034452 [dynactin binding]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043274 [phospholipase binding]
GO:0046469 [platelet activating factor metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047496 [vesicle transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048854 [brain morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051010 [microtubule plus-end binding]
GO:0051012 [microtubule sliding]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070840 [dynein complex binding]
GO:1904115 [axon cytoplasm]
Show all
 410 aa
46.6 kDa 		No 0
PAFAH1B1-226
ENSP00000502735
ENST00000676098
P43034
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000235 [astral microtubule]
GO:0000776 [kinetochore]
GO:0001675 [acrosome assembly]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005938 [cell cortex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007268 [chemical synaptic transmission]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007611 [learning or memory]
GO:0008017 [microtubule binding]
GO:0008090 [retrograde axonal transport]
GO:0008201 [heparin binding]
GO:0008247 [1-alkyl-2-acetylglycerophosphocholine esterase complex]
GO:0008344 [adult locomotory behavior]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0019226 [transmission of nerve impulse]
GO:0021540 [corpus callosum morphogenesis]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0031023 [microtubule organizing center organization]
GO:0031252 [cell leading edge]
GO:0031514 [motile cilium]
GO:0031965 [nuclear membrane]
GO:0034452 [dynactin binding]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043274 [phospholipase binding]
GO:0046469 [platelet activating factor metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047496 [vesicle transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048854 [brain morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051010 [microtubule plus-end binding]
GO:0051012 [microtubule sliding]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070840 [dynein complex binding]
GO:1904115 [axon cytoplasm]
Show all
 410 aa
46.6 kDa 		No 0
PAFAH1B1-227
ENSP00000502577
ENST00000676188
P43034
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000235 [astral microtubule]
GO:0000776 [kinetochore]
GO:0001675 [acrosome assembly]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005938 [cell cortex]
GO:0006629 [lipid metabolic process]
GO:0007017 [microtubule-based process]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007268 [chemical synaptic transmission]
GO:0007281 [germ cell development]
GO:0007399 [nervous system development]
GO:0007405 [neuroblast proliferation]
GO:0007611 [learning or memory]
GO:0008017 [microtubule binding]
GO:0008090 [retrograde axonal transport]
GO:0008201 [heparin binding]
GO:0008247 [1-alkyl-2-acetylglycerophosphocholine esterase complex]
GO:0008344 [adult locomotory behavior]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0019226 [transmission of nerve impulse]
GO:0021540 [corpus callosum morphogenesis]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0031023 [microtubule organizing center organization]
GO:0031252 [cell leading edge]
GO:0031514 [motile cilium]
GO:0031965 [nuclear membrane]
GO:0034452 [dynactin binding]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043274 [phospholipase binding]
GO:0046469 [platelet activating factor metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0047496 [vesicle transport along microtubule]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048854 [brain morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051010 [microtubule plus-end binding]
GO:0051012 [microtubule sliding]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:0070840 [dynein complex binding]
GO:1904115 [axon cytoplasm]
Show all
 410 aa
46.6 kDa 		No 0
PAFAH1B1-229
ENSP00000502737
ENST00000676353
A0A6Q8PFT2
[Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of the nervous system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0007049 [cell cycle]
GO:0007399 [nervous system development]
GO:0016042 [lipid catabolic process]
GO:0030154 [cell differentiation]
GO:0051301 [cell division]
Show all
 345 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org