We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.1
Chromosome location (bp)
64269830 - 64284704
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666[response to hypoxia] GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006007[glucose catabolic process] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007283[spermatogenesis] GO:0008289[lipid binding] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0009410[response to xenobiotic stimulus] GO:0009725[response to hormone] GO:0009749[response to glucose] GO:0010033[response to organic substance] GO:0010508[positive regulation of autophagy] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0014070[response to organic cyclic compound] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019051[induction by virus of host apoptotic process] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0021987[cerebral cortex development] GO:0030346[protein phosphatase 2B binding] GO:0032024[positive regulation of insulin secretion] GO:0032355[response to estradiol] GO:0032570[response to progesterone] GO:0033133[positive regulation of glucokinase activity] GO:0033574[response to testosterone] GO:0034201[response to oleic acid] GO:0035774[positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042542[response to hydrogen peroxide] GO:0042593[glucose homeostasis] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043200[response to amino acid] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043281[regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043422[protein kinase B binding] GO:0044342[type B pancreatic cell proliferation] GO:0045471[response to ethanol] GO:0045579[positive regulation of B cell differentiation] GO:0045582[positive regulation of T cell differentiation] GO:0045862[positive regulation of proteolysis] GO:0046031[ADP metabolic process] GO:0046034[ATP metabolic process] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046931[pore complex assembly] GO:0050673[epithelial cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051384[response to glucocorticoid] GO:0051592[response to calcium ion] GO:0071247[cellular response to chromate] GO:0071260[cellular response to mechanical stimulus] GO:0071316[cellular response to nicotine] GO:0071396[cellular response to lipid] GO:0071456[cellular response to hypoxia] GO:0071889[14-3-3 protein binding] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097138[BAD-BCL-2 complex] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097202[activation of cysteine-type endopeptidase activity] GO:1901216[positive regulation of neuron death] GO:1901423[response to benzene] GO:1902220[positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress] GO:1904710[positive regulation of granulosa cell apoptotic process] GO:2000078[positive regulation of type B pancreatic cell development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008289[lipid binding] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010508[positive regulation of autophagy] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0032024[positive regulation of insulin secretion] GO:0033133[positive regulation of glucokinase activity] GO:0042593[glucose homeostasis] GO:0043065[positive regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044342[type B pancreatic cell proliferation] GO:0045862[positive regulation of proteolysis] GO:0046031[ADP metabolic process] GO:0046034[ATP metabolic process] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046931[pore complex assembly] GO:0050679[positive regulation of epithelial cell proliferation] GO:0071260[cellular response to mechanical stimulus] GO:0071316[cellular response to nicotine] GO:0071456[cellular response to hypoxia] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097138[BAD-BCL-2 complex] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097193[intrinsic apoptotic signaling pathway] GO:0097202[activation of cysteine-type endopeptidase activity] GO:2000078[positive regulation of type B pancreatic cell development]
The Human Protein Atlas project is funded
