Cell lines

Name
Description of cell line
Original reference
Origin
Sex & Age 
Source
Cellosaurus (ExPaSy)

Brain

AF22 iPS derived Neuroepithelia stem (NES) cell line Falk et al., PLoS One 7(1) (2012) Skin Female, 36 NA Uncategorised
SH-SY5Y Metastatic neuroblastoma, clonal subline of neuroepithelioma cell line SK-N-SH Biedler et al., Cancer Res 33: 2643 (1973) Bone marrow Female, 4 DSMZ CVCL_0019
Cancer cell line
U-251MG Glioblastoma cell line Westermark B., Int J Cancer12: 438 (1973) Brain Male BW1 CVCL_0021
Cancer cell line
GAMG Glioblastoma cell line Akslen et al, Anticancer Res. 8(4): 797-803 (1988) Female, 42 DSMZ CVCL_1226
Cancer cell line

Eye

HTERT-RPE1 Retinal pigment epithelial cells immortalized with hTERT Rambhatla L et al.. Invest Ophthalmol Vis Sci. 43(5):1622-30. (2002) Retina, eye Female, 1 CVCL_4388
Telomerase immortalized cell line
HTCEpi Telomerase-immortalized corneal epithelial cell line Robertson et al., Invest Ophthalmol Vis Sci 46(2): 470-478 (2005) Cornea Male, 62 Evercyte CVCL_AQ44
Telomerase immortalized cell line
HTERT-RPE1 (serum starved) Retinal pigment epithelial cells immortalized with hTERT Rambhatla L et al.. Invest Ophthalmol Vis Sci. 43(5):1622-30. (2002) Retina, eye Female, 1 CVCL_4388
Telomerase immortalized cell line

Proximal digestive tract

OE19 Esophageal adenocarcinoma cell line PMID: 9010035 Esophagus Male, 72 DSMZ CVCL_1622
Cancer cell line

Gastrointestinal tract

CACO-2 Colon adenocarcinoma cell line Fogh J., et al. J. Natl. Cancer Inst. 58: 209 (1977) Colon Male, 72 DSMZ CVCL_0025
Cancer cell line

Liver & Gallbladder

Hep-G2 Hepatocellular carcinoma cell line Aden et al., Nature 282: 615 (1979) Liver Male, 15 DSMZ CVCL_0027
Cancer cell line

Kidney & Urinary bladder

RPTEC/TERT1 Proximal tubular epithelial cell line Wieser et al., Am J Physiol Renal Physiol 295(5): 1365-1375 (2008) Human kidney cortex Male Evercyte CVCL_K278
Telomerase immortalized cell line
RT-4 Urinary bladder transitional cell carcinoma cell line Rigby et al., Br J Cancer 24: 746 (1970) Urinary bladder Male, 63 DSMZ/ECACC CVCL_0036
Cancer cell line
HEK293 Embryonal kidney cell line, transformed by adenovirus type 5 Graham et al., J Gen Virol 36: 59 (1977) Embryonal kidney Female DSMZ CVCL_0045
Transformed cell line

Male reproductive system

Sperm Male Uncategorised
PC-3 Metastatic poorly differentiated prostate adenocarcinoma cell line Kaighn et al., Invest Urol 17: 16-23 (1979) Bone marrow Male, 62 DSMZ CVCL_0035
Cancer cell line
SuSa Testicular germ cell tumor PMID: 593370 Testis Male, 30 DSMZ CVCL_L280
Cancer cell line

Skin

HaCaT Keratinocyte cell line Boukamp et al., J Cell Biol Mar 106(3): 761 (1988) Skin Male NEF2 CVCL_0038
Spontaneously immortalized cell line
A-431 Epidermoid carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) Skin Female, 85 DSMZ CVCL_0037
Cancer cell line
SK-MEL-30 Metastatic malignant melanoma cell line Carey et al., Proc Natl Acad Sci USA 73: 3278 (1976) Subcutis Male, 67 DSMZ CVCL_0039
Cancer cell line

Lung

HBEC3-KT Immortalized human bronchial epithelial cell line Central lung bronchiole Female, 65 Evercyte CVCL_X491
Telomerase immortalized cell line
A-549 Lung carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) Lung Male, 58 DSMZ CVCL_0023
Cancer cell line

Female reproductive system

HeLa Cervical epithelial adenocarcinoma cell line Scherer et al., J Exp Med 97: 695 (1953) Cervix Female, 31 DSMZ CVCL_0030
Cancer cell line
HTERT-HME1 Immortalized mammary epithelial cell line Mammary gland Female, 53 Evercyte CVCL_3383
Telomerase immortalized cell line
EFO-21 Metastatic ovarian serous cystadenocarcinoma cell line Simon et al., J Natl Cancer Inst 70: 839 (1983) Ascites Female, 56 DSMZ CVCL_0029
Cancer cell line
MCF-7 Metastatic breast adenocarcinoma cell line Soule et al., J Natl Cancer Inst 51: 1409 (1973) Pleural effusion Female, 69 DSMZ CVCL_0031
Cancer cell line
SiHa Cervical squamous cell carcinoma cell line, integrated 1-2 copies of HPV16 Friedl F. et al.Proc., Soc. Exp. Biol. Med. 135: 543-545 (1970) Cervix Female, 55 LGC/ATCC CVCL_0032
Cancer cell line

Endothelial

HUVEC/TERT2 Umbilical vein endothelial cell line NA Umbilical vein Female Evercyte CVCL_9Q53
Telomerase immortalized cell line

Mesenchymal

Rh30 Metastatic rhabdomyosarcoma cell line Douglass et al., Cytogenet Cell Genet 45: 148-155 (1987) Bone marrow Male, 17 DSMZ CVCL_0041
Cancer cell line
ASC52telo Adipose tissue-derived mesenchymal stem cell line Wolbank S. et al., Tissue Eng Part A: Jul;15(7):1843-54 (2009) Adipose tissue Female Evercyte CVCL_U602
Telomerase immortalized cell line
HBF/TERT88 Adherent brain fibroblast cell line NA Brain Female Evercyte CVCL_9Q52
Telomerase immortalized cell line
BJ [Human fibroblast] Adherent fibroblast cell line Bodnar AG., et al. Science 279: 349-352 (1998) Foreskin Male LGC/ATCC CVCL_3653
Finite cell line
LHCN-M2 Adherent myoblast cell line Zhu et al., Aging Cell 6(4): 515-523 (2007) Satellite cells (from pectoralis major muscle) Male, 41 Evercyte CVCL_8890
Telomerase immortalized cell line
FHDF/TERT166 Immortalized human foreskin fibroblast cell line Foreskin Male Evercyte CVCL_GZ73
Telomerase immortalized cell line
U2OS Osteosarcoma cell line Ponten J., Saksela E. Int. J. Cancer 2: 434 (1967) Bone Female, 15 LGC/ATCC CVCL_0042
Cancer cell line

Lymphoid

JURKAT T-cell leukemia cell line Peripheral blood Male, 14 DSMZ CVCL_0065
Cancer cell line
REH** Pre-B cell leukemia cell line (ALL, first relapse) Rosenfeld et al., Nature 267: 841–3 (1977) Peripheral blood Female, 15 DSMZ CVCL_1650
Cancer cell line
HTEC/SVTERT24-B Immortalized thymic epithelial cell line Thymus Female Evercyte CVCL_JM27
Transformed cell line
HDLM-2 Hodgkin lymphoma cell line Drexler et al., Leuk Res 10: 487 (1986) Pleural effusion Male, 74 DSMZ CVCL_0009
Cancer cell line

Myeloid

NB4 Acute promyelocytic leukemia (APL) cell line Lanotte et al., Blood 77: 1080 (1991) Bone marrow Female, 23 DSMZ CVCL_0005
Cancer cell line
K-562 Chronic myeloid leukemia (CML) cell line Lozzio et al., J Natl Cancer Inst 50: 535 (1973) Pleural effusion Female, 53 DSMZ CVCL_0004
Cancer cell line
THP-1 Acute monocytic leukemia (AML) cell line Tsuchiya et al., Int J Cancer 26: 171 (1980) Peripheral blood Male, 1 DSMZ CVCL_0006
Cancer cell line
HEL Erythroleukemia cell line (AML M6 in relapse after treatment for Hodgkin's disease) Martin et al., Science 216: 1233 (1982) Peripheral blood Male, 30 DSMZ CVCL_0001
Cancer cell line
HAP1 Haploid karyotype cell line from Chronic myelogenous leukemia Carette et al., Nature 477(7364): 340-343 (2011) Leukemia Male Horizon Discovery CVCL_Y019
Cancer cell line

Renal, urinary, male reproductive system

PODO/TERT256 Female Evercyte CVCL_JL76
PODO/SVTERT152 Urine visceral epithelial cells Male, 41 Evercyte CVCL_B5ST

Mouse

NIH 3T3 Mouse embryonal fibroblast cell line Aaronson et al., J Cell Physio 72(2): 141-148 (1968) Embryo DSMZ CVCL_0594
Spontaneously immortalized cell line

Notes

*
Allen M, Bjerke M, Edlund H, Nelander S and Westermark B: Origin of the U87MG glioma cell line: Good news and bad news. Science Translational Medicine 31 Aug 2016: Vol. 8, Issue 354, pp. 354. DOI: 10.1126/scitranslmed.aaf6853
**
REH was previously listed as KM3. Due to misidentification, KM3 has been deleted from the DSMZ catalogue and the true identity is REH. DSMZ - False leukemia and lymphoma cell lines. Drexler et al., False leukemia-lymphoma cell lines: An update on over 500 cell lines. Leukemia 17: 416-426 (2003)

Source information

  1. Prof. Bengt Westermark, Uppsala University, Uppsala, Sweden
  2. Prof. Norbert E Fusenig, DKFZ, Heidelberg, Germany

Hematopoietic cell lines

Schematic description of hematopoietic differentiation lineages, and cellular origin for hematopoietic cell lines.