Protein detected in human plasma by immunoassays

In this chapter the estimated protein concentrations of proteins detected in human plasma using immunoasays is presented. Reference plasma concentrations for 453 proteins actively secreted to blood were collected based on published research articles where immunoassays had been used to measure the target proteins. The concentrations of the proteins for which reference values could be obtained ranged over 10 orders of magnitude from 40 mg/ml for human serum albumin down to 4 pg/ml for interleukin 5.

Figure 1. Plot showing the protein concentration rank in relation to 452 other proteins secreted to blood (x-axis) as well as concentration on an absolute scale (y-axis) with a handful selected plasma proteins marked in the graph.

Figure 2. Violin plots showing the distribution of plasma concentrations for 22 different groups based on their main protein function.

Apolipoprotein, enzyme inhibitors and proteins involved in transport generally show high plasma concentrations above 1 ug/ml. In contrast, chemokines and cytokines, especially interleukins and interferons, are found in the lower end of the concentration range below 1 ng/ml together with hormones, neuropeptides and growth factors.

Table 1. Concentrations for proteins secreted to blood. Measured by immunoassays.

Gene	Gene description	Mean concentration	Reference
ALB	Albumin	40 g/L	40 g/L
A2M	Alpha-2-macroglobulin	1.6 g/L	2.9 g/L 1.0 g/L 950 mg/L
TF	Transferrin	20 g/L	31 g/L 26 g/L 2.5 g/L
SERPINA1	Serpin family A member 1	1.9 g/L	3.1 g/L 2.3 g/L 1.9 g/L 1.6 g/L 1.5 g/L 1.2 g/L
APOA1	Apolipoprotein A1	1.5 g/L	3.0 g/L 1.4 g/L 740 mg/L 700 mg/L
SERPINA3	Serpin family A member 3	700 mg/L	1.1 g/L 330 mg/L
C3	Complement C3	1.3 g/L	1.7 g/L 1.6 g/L 1.2 g/L 920 mg/L 900 mg/L
HPX	Hemopexin	430 mg/L	750 mg/L 100 mg/L
APOB	Apolipoprotein B	1.5 g/L	1.9 g/L 1.9 g/L 1.5 g/L 720 mg/L
CFH	Complement factor H	400 mg/L	640 mg/L 290 mg/L 260 mg/L
ORM1	Orosomucoid 1	950 mg/L	1.5 g/L 730 mg/L 610 mg/L
VTN	Vitronectin	610 mg/L	1.4 g/L 930 mg/L 340 mg/L 320 mg/L 9.7 mg/L
APOA2	Apolipoprotein A2	110 mg/L	300 mg/L 160 mg/L 490 µg/L 360 µg/L
C4B	Complement C4B (Chido blood group)	450 mg/L	600 mg/L 290 mg/L
TTR	Transthyretin	350 mg/L	400 mg/L 290 mg/L
C4BPB	Complement component 4 binding protein beta	270 mg/L	270 mg/L
FGG	Fibrinogen gamma chain	270 mg/L	300 mg/L 290 mg/L 250 mg/L 230 mg/L
FN1	Fibronectin 1	230 mg/L	230 mg/L
AHSG	Alpha 2-HS glycoprotein	860 mg/L	1.3 g/L 1.1 g/L 230 mg/L
CRISPLD2	Cysteine rich secretory protein LCCL domain containing 2	220 mg/L	220 mg/L
C5	Complement C5	110 mg/L	200 mg/L 26 mg/L
A1BG	Alpha-1-B glycoprotein	200 mg/L	200 mg/L
APOH	Apolipoprotein H	250 mg/L	290 mg/L 280 mg/L 170 mg/L
CP	Ceruloplasmin	160 mg/L	160 mg/L
APOA4	Apolipoprotein A4	61 mg/L	150 mg/L 20 mg/L 15 mg/L
PLG	Plasminogen	140 mg/L	140 mg/L
GC	GC vitamin D binding protein	140 mg/L	240 mg/L 120 mg/L 70 mg/L
HRG	Histidine rich glycoprotein	120 mg/L	130 mg/L 110 mg/L
F2	Coagulation factor II, thrombin	110 mg/L	110 mg/L 110 mg/L
GPLD1	Glycosylphosphatidylinositol specific phospholipase D1	100 mg/L	160 mg/L 110 mg/L 40 mg/L
C1S	Complement C1s	93 mg/L	93 mg/L
FETUB	Fetuin B	48 mg/L	91 mg/L 4.0 mg/L
KNG1	Kininogen 1	90 mg/L	90 mg/L
C9	Complement C9	70 mg/L	82 mg/L 58 mg/L
GSN	Gelsolin	110 mg/L	130 mg/L 130 mg/L 81 mg/L
ANXA2	Annexin A2	27 mg/L	80 mg/L 1.1 µg/L 7.9 ng/L
LPA	Lipoprotein(a)	79 mg/L	79 mg/L
CFHR1	Complement factor H related 1	75 mg/L	75 mg/L
APOC3	Apolipoprotein C3	110 mg/L	130 mg/L 120 mg/L 110 mg/L 64 mg/L
SERPINA6	Serpin family A member 6	61 mg/L	61 mg/L
APOC1	Apolipoprotein C1	20 mg/L	60 mg/L 400 µg/L 380 µg/L
PON1	Paraoxonase 1	96 mg/L	150 mg/L 79 mg/L 59 mg/L
SAA4	Serum amyloid A4, constitutive	65 mg/L	78 mg/L 62 mg/L 55 mg/L
AZGP1	Alpha-2-glycoprotein 1, zinc-binding	55 mg/L	59 mg/L 51 mg/L
CFHR4	Complement factor H related 4	28 mg/L	50 mg/L 6.0 mg/L
HPR	Haptoglobin-related protein	49 mg/L	49 mg/L
AFM	Afamin	55 mg/L	62 mg/L 47 mg/L
C6	Complement C6	45 mg/L	45 mg/L
APOC2	Apolipoprotein C2	43 mg/L	43 mg/L
CLU	Clusterin	170 mg/L	270 mg/L 240 mg/L 180 mg/L 110 mg/L 41 mg/L
CFHR2	Complement factor H related 2	40 mg/L	40 mg/L
C2	Complement C2	38 mg/L	38 mg/L
APOE	Apolipoprotein E	52 mg/L	70 mg/L 62 mg/L 39 mg/L 36 mg/L
SERPINA7	Serpin family A member 7	40 mg/L	65 mg/L 56 mg/L 32 mg/L 6.6 mg/L
C4BPA	Complement component 4 binding protein alpha	31 mg/L	31 mg/L
SERPINA4	Serpin family A member 4	15 mg/L	29 mg/L 5.6 µg/L
KLKB1	Kallikrein B1	29 mg/L	29 mg/L
APCS	Amyloid P component, serum	28 mg/L	28 mg/L
RNLS	Renalase, FAD dependent amine oxidase	11 mg/L	28 mg/L 4.0 mg/L 120 µg/L
LRG1	Leucine rich alpha-2-glycoprotein 1	21 mg/L	25 mg/L 17 mg/L
LBP	Lipopolysaccharide binding protein	25 mg/L	32 mg/L 22 mg/L 21 mg/L
PROS1	Protein S	22 mg/L	23 mg/L 22 mg/L
CFI	Complement factor I	30 mg/L	42 mg/L 19 mg/L
CFP	Complement factor properdin	18 mg/L	18 mg/L
RBP4	Retinol binding protein 4	46 mg/L	84 mg/L 37 mg/L 18 mg/L
APOF	Apolipoprotein F	18 mg/L	18 mg/L
FCN3	Ficolin 3	23 mg/L	33 mg/L 18 mg/L 17 mg/L
PLTP	Phospholipid transfer protein	9.7 mg/L	16 mg/L 12 mg/L 1.6 mg/L
SERPINF1	Serpin family F member 1	9.3 mg/L	15 mg/L 9.0 mg/L 4.3 mg/L
ADIPOQ	Adiponectin, C1Q and collagen domain containing	8.4 mg/L	15 mg/L 8.0 mg/L 5.9 mg/L 5.0 mg/L
IGFALS	Insulin like growth factor binding protein acid labile subunit	15 mg/L	16 mg/L 14 mg/L
FCN2	Ficolin 2	8.1 mg/L	12 mg/L 7.0 mg/L 5.0 mg/L
HABP2	Hyaluronan binding protein 2	20 mg/L	29 mg/L 20 mg/L 12 mg/L
MASP1	MBL associated serine protease 1	8.7 mg/L	9.7 mg/L 9.4 mg/L 6.9 mg/L
CNDP1	Carnosine dipeptidase 1	9.4 mg/L	9.4 mg/L
CLEC3B	C-type lectin domain family 3 member B	6.5 mg/L	8.5 mg/L 4.5 mg/L
F5	Coagulation factor V	7.7 mg/L	8.3 mg/L 7.0 mg/L
C1RL	Complement C1r subcomponent like	5.5 mg/L	5.5 mg/L
LCAT	Lecithin-cholesterol acyltransferase	6.5 mg/L	7.9 mg/L 5.1 mg/L
CD5L	CD5 molecule like	4.0 mg/L	6.1 mg/L 5.0 mg/L 3.1 mg/L 2.0 mg/L
SERPINA10	Serpin family A member 10	4.0 mg/L	4.4 mg/L 3.5 mg/L
BCHE	Butyrylcholinesterase	3.8 mg/L	3.8 mg/L
AMBP	Alpha-1-microglobulin/bikunin precursor	3.3 mg/L	3.3 mg/L
APOL1	Apolipoprotein L1	1.6 mg/L	3.2 mg/L 33 µg/L
IGFBP3	Insulin like growth factor binding protein 3	3.2 mg/L	3.8 mg/L 3.1 mg/L 2.9 mg/L
CFHR5	Complement factor H related 5	2.6 mg/L	3.0 mg/L 2.1 mg/L
CTSD	Cathepsin D	760 µg/L	2.7 mg/L 200 µg/L 130 µg/L 4.2 µg/L
CTSB	Cathepsin B	520 µg/L	2.5 mg/L 75 µg/L 24 µg/L 14 µg/L 4.2 µg/L
CETP	Cholesteryl ester transfer protein	2.5 mg/L	2.5 mg/L
CD14	CD14 molecule	2.8 mg/L	3.4 mg/L 3.3 mg/L 2.3 mg/L 2.0 mg/L
GPX3	Glutathione peroxidase 3	5.1 mg/L	13 mg/L 2.3 mg/L 28 µg/L
APOO	Apolipoprotein O	2.2 mg/L	2.2 mg/L
B2M	Beta-2-microglobulin	1.8 mg/L	2.0 mg/L 1.6 mg/L
CD163	CD163 molecule	900 µg/L	1.9 mg/L 810 µg/L 30 µg/L
COLEC10	Collectin subfamily member 10	1.9 mg/L	1.9 mg/L
PON3	Paraoxonase 3	1.8 mg/L	1.8 mg/L 1.8 mg/L 1.7 mg/L
PROZ	Protein Z, vitamin K dependent plasma glycoprotein	1.7 mg/L	2.0 mg/L 1.7 mg/L 1.4 mg/L
FCN1	Ficolin 1	1.1 mg/L	1.7 mg/L 1.2 mg/L 300 µg/L
CRP	C-reactive protein	2.9 mg/L	5.2 mg/L 5.0 mg/L 2.4 mg/L 1.7 mg/L 1.6 mg/L 1.6 mg/L
TFRC	Transferrin receptor	1.3 mg/L	1.3 mg/L
ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif 13	1.3 mg/L	1.3 mg/L
CFD	Complement factor D	730 µg/L	1.3 mg/L 900 µg/L 25 µg/L
CST3	Cystatin C	1.0 mg/L	1.0 mg/L 1.0 mg/L
APOC4	Apolipoprotein C4	1.0 mg/L	1.0 mg/L
LYZ	Lysozyme	1.5 mg/L	2.1 mg/L 900 µg/L
MBL2	Mannose binding lectin 2	1.2 mg/L	2.3 mg/L 900 µg/L 500 µg/L
CFB	Complement factor B	880 µg/L	880 µg/L
CRHBP	Corticotropin releasing hormone binding protein	720 µg/L	720 µg/L
CCL28	C-C motif chemokine ligand 28	700 µg/L	700 µg/L
VCAM1	Vascular cell adhesion molecule 1	620 µg/L	650 µg/L 600 µg/L
CAMP	Cathelicidin antimicrobial peptide	620 µg/L	1.2 mg/L 650 µg/L 21 µg/L
IGFBP2	Insulin like growth factor binding protein 2	300 µg/L	620 µg/L 460 µg/L 66 µg/L 66 µg/L
DPP4	Dipeptidyl peptidase 4	640 µg/L	700 µg/L 580 µg/L
CFHR3	Complement factor H related 3	580 µg/L	610 µg/L 550 µg/L
IGF2	Insulin like growth factor 2	610 µg/L	950 µg/L 530 µg/L 340 µg/L
C1QC	Complement C1q C chain	510 µg/L	510 µg/L
MASP2	MBL associated serine protease 2	340 µg/L	490 µg/L 290 µg/L 240 µg/L
LIPG	Lipase G, endothelial type	660 µg/L	870 µg/L 440 µg/L
FGFBP2	Fibroblast growth factor binding protein 2	350 µg/L	440 µg/L 250 µg/L
SPP1	Secreted phosphoprotein 1	110 µg/L	440 µg/L 55 µg/L 47 µg/L 18 µg/L 9.3 µg/L
C1QTNF9	C1q and TNF related 9	210 µg/L	420 µg/L 4.7 µg/L
CCN3	Cellular communication network factor 3	270 µg/L	410 µg/L 390 µg/L 6.1 µg/L
FGA	Fibrinogen alpha chain	410 µg/L	410 µg/L
CXCL17	C-X-C motif chemokine ligand 17	400 µg/L	400 µg/L
ITLN1	Intelectin 1	290 µg/L	490 µg/L 370 µg/L 19 µg/L
C1QTNF6	C1q and TNF related 6	350 µg/L	350 µg/L
VWF	Von Willebrand factor	28 mg/L	46 mg/L 38 mg/L 350 µg/L
GREM1	Gremlin 1, DAN family BMP antagonist	240 µg/L	350 µg/L 220 µg/L 150 µg/L
C1QTNF5	C1q and TNF related 5	220 µg/L	340 µg/L 160 µg/L 150 µg/L
C4A	Complement C4A (Rodgers blood group)	340 µg/L	340 µg/L
C1QTNF1	C1q and TNF related 1	310 µg/L	320 µg/L 310 µg/L
SAA1	Serum amyloid A1	300 µg/L	300 µg/L
CPN2	Carboxypeptidase N subunit 2	300 µg/L	300 µg/L
CD44	CD44 molecule (Indian blood group)	260 µg/L	260 µg/L
MET	MET proto-oncogene, receptor tyrosine kinase	180 µg/L	260 µg/L 98 µg/L
ANG	Angiogenin	310 µg/L	450 µg/L 240 µg/L 230 µg/L
C1QTNF7	C1q and TNF related 7	240 µg/L	240 µg/L
COLEC11	Collectin subfamily member 11	300 µg/L	340 µg/L 320 µg/L 240 µg/L
ORM2	Orosomucoid 2	420 µg/L	1.2 mg/L 230 µg/L 200 µg/L 95 µg/L
ANGPTL3	Angiopoietin like 3	220 µg/L	220 µg/L
SERPINE1	Serpin family E member 1	140 µg/L	210 µg/L 70 µg/L
IGFBP5	Insulin like growth factor binding protein 5	110 µg/L	210 µg/L 11 µg/L
IGFBP4	Insulin like growth factor binding protein 4	230 µg/L	440 µg/L 190 µg/L 190 µg/L 85 µg/L
HP	Haptoglobin	1000 mg/L	2.4 g/L 1.6 g/L 190 µg/L 180 µg/L
ACE	Angiotensin I converting enzyme	100 µg/L	170 µg/L 94 µg/L 80 µg/L 73 µg/L
IGF1	Insulin like growth factor 1	100 µg/L	180 µg/L 170 µg/L 41 µg/L 19 µg/L
FCRL5	Fc receptor like 5	170 µg/L	170 µg/L
BMP4	Bone morphogenetic protein 4	160 µg/L	160 µg/L
IGFBP6	Insulin like growth factor binding protein 6	200 µg/L	390 µg/L 150 µg/L 140 µg/L 120 µg/L
PCSK9	Proprotein convertase subtilisin/kexin type 9	140 µg/L	140 µg/L
GRN	Granulin precursor	140 µg/L	140 µg/L
CCL25	C-C motif chemokine ligand 25	180 µg/L	230 µg/L 140 µg/L
RLN3	Relaxin 3	60 µg/L	120 µg/L 69 ng/L
SOD3	Superoxide dismutase 3	50 µg/L	120 µg/L 35 µg/L 33 µg/L 18 µg/L
APOA5	Apolipoprotein A5	110 µg/L	110 µg/L
DEFA1	Defensin alpha 1	110 µg/L	110 µg/L
ADA2	Adenosine deaminase 2	110 µg/L	110 µg/L
FAP	Fibroblast activation protein alpha	110 µg/L	110 µg/L
TIMP1	TIMP metallopeptidase inhibitor 1	130 µg/L	190 µg/L 140 µg/L 110 µg/L 95 µg/L 95 µg/L
RARRES2	Retinoic acid receptor responder 2	75 µg/L	75 µg/L
ELANE	Elastase, neutrophil expressed	160 µg/L	240 µg/L 70 µg/L
ANGPT1	Angiopoietin 1	32 µg/L	67 µg/L 29 µg/L 58 ng/L
SDC1	Syndecan 1	63 µg/L	63 µg/L
S100A12	S100 calcium binding protein A12	29 µg/L	63 µg/L 60 µg/L 11 µg/L 8.1 µg/L 800 ng/L
ALCAM	Activated leukocyte cell adhesion molecule	60 µg/L	60 µg/L
FBN1	Fibrillin 1	51 µg/L	51 µg/L
SAA2	Serum amyloid A2	50 µg/L	50 µg/L
SELENOP	Selenoprotein P	2.2 mg/L	4.4 mg/L 46 µg/L
C1QTNF3	C1q and TNF related 3	44 µg/L	44 µg/L
CCK	Cholecystokinin	44 µg/L	44 µg/L
C1QTNF12	C1q and TNF related 12	38 µg/L	38 µg/L
CCL5	C-C motif chemokine ligand 5	20 µg/L	37 µg/L 21 µg/L 16 µg/L 6.3 µg/L
FGL2	Fibrinogen like 2	39 µg/L	62 µg/L 36 µg/L 18 µg/L
CHIT1	Chitinase 1	26 µg/L	35 µg/L 18 µg/L
CHI3L1	Chitinase 3 like 1	25 µg/L	39 µg/L 33 µg/L 3.9 µg/L
CD55	CD55 molecule (Cromer blood group)	32 µg/L	32 µg/L
SLPI	Secretory leukocyte peptidase inhibitor	26 µg/L	45 µg/L 32 µg/L 1.8 µg/L
INSL5	Insulin like 5	39 µg/L	45 µg/L 32 µg/L
IGFBP7	Insulin like growth factor binding protein 7	30 µg/L	30 µg/L
CSH1	Chorionic somatomammotropin hormone 1	30 µg/L	30 µg/L
APOD	Apolipoprotein D	99 mg/L	150 mg/L 150 mg/L 28 µg/L
HLA-G	Major histocompatibility complex, class I, G	33 µg/L	39 µg/L 27 µg/L
PPBP	Pro-platelet basic protein	25 µg/L	25 µg/L
IGFBP1	Insulin like growth factor binding protein 1	28 µg/L	32 µg/L 24 µg/L
IL6R	Interleukin 6 receptor	25 µg/L	27 µg/L 23 µg/L
CCL18	C-C motif chemokine ligand 18	55 µg/L	90 µg/L 78 µg/L 53 µg/L 35 µg/L 23 µg/L
IL1RL1	Interleukin 1 receptor like 1	19 µg/L	35 µg/L 22 µg/L 220 ng/L
MIF	Macrophage migration inhibitory factor	14 µg/L	22 µg/L 5.7 µg/L
FLT4	Fms related receptor tyrosine kinase 4	20 µg/L	20 µg/L
TNFSF13	TNF superfamily member 13	6.8 µg/L	20 µg/L 300 ng/L 780 pg/L
BDNF	Brain derived neurotrophic factor	16 µg/L	40 µg/L 20 µg/L 18 µg/L 2.4 µg/L 62 ng/L
LEP	Leptin	17 µg/L	17 µg/L 17 µg/L
PRL	Prolactin	54 µg/L	260 µg/L 16 µg/L 16 µg/L 14 µg/L 10 µg/L 7.5 µg/L
BGLAP	Bone gamma-carboxyglutamate protein	16 µg/L	16 µg/L
ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	15 µg/L	15 µg/L
CPA3	Carboxypeptidase A3	7.5 µg/L	15 µg/L 37 ng/L
TFPI	Tissue factor pathway inhibitor	58 µg/L	150 µg/L 15 µg/L 7.8 µg/L
AZU1	Azurocidin 1	14 µg/L	14 µg/L
LECT2	Leukocyte cell derived chemotaxin 2	27 µg/L	44 µg/L 23 µg/L 13 µg/L
MIA	MIA SH3 domain containing	8.3 µg/L	12 µg/L 8.8 µg/L 3.6 µg/L
FAS	Fas cell surface death receptor	12 µg/L	12 µg/L 12 µg/L
SPON1	Spondin 1	12 µg/L	12 µg/L
ADGRE5	Adhesion G protein-coupled receptor E5	10 µg/L	10 µg/L
APOM	Apolipoprotein M	7.4 mg/L	15 mg/L 8.6 µg/L
PLAT	Plasminogen activator, tissue type	9.9 µg/L	11 µg/L 10 µg/L 8.4 µg/L
SPARC	Secreted protein acidic and cysteine rich	8.3 µg/L	8.3 µg/L
ANGPTL1	Angiopoietin like 1	8.0 µg/L	8.0 µg/L
RETN	Resistin	5.1 µg/L	7.9 µg/L 6.7 µg/L 4.7 µg/L 3.4 µg/L 2.8 µg/L
GAS6	Growth arrest specific 6	8.9 µg/L	13 µg/L 9.9 µg/L 7.8 µg/L 5.4 µg/L
ANGPTL4	Angiopoietin like 4	7.8 µg/L	7.8 µg/L
PF4	Platelet factor 4	7.7 µg/L	7.7 µg/L
MFGE8	Milk fat globule EGF and factor V/VIII domain containing	2.8 µg/L	7.6 µg/L 790 ng/L 100 ng/L
TEK	TEK receptor tyrosine kinase	7.8 µg/L	8.3 µg/L 7.5 µg/L 7.5 µg/L
GHRL	Ghrelin and obestatin prepropeptide	2.6 µg/L	7.4 µg/L 220 ng/L 130 ng/L
PLA2G7	Phospholipase A2 group VII	7.4 µg/L	7.4 µg/L
AIMP1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1	6.5 µg/L	6.5 µg/L
MMP9	Matrix metallopeptidase 9	43 µg/L	80 µg/L 6.4 µg/L
GDF2	Growth differentiation factor 2	2.2 µg/L	6.2 µg/L 310 ng/L 110 ng/L
AFP	Alpha fetoprotein	3.0 µg/L	6.0 µg/L 2.0 µg/L 1.0 µg/L
CD6	CD6 molecule	5.3 µg/L	5.3 µg/L
CCL14	C-C motif chemokine ligand 14	5.2 µg/L	5.2 µg/L
ISG15	ISG15 ubiquitin like modifier	5.0 µg/L	5.0 µg/L
EGFR	Epidermal growth factor receptor	4.7 µg/L	5.0 µg/L 4.5 µg/L
BPI	Bactericidal permeability increasing protein	7.3 µg/L	10 µg/L 4.6 µg/L
ACE2	Angiotensin converting enzyme 2	4.5 µg/L	4.5 µg/L
ITIH1	Inter-alpha-trypsin inhibitor heavy chain 1	4.5 µg/L	4.5 µg/L
HGF	Hepatocyte growth factor	4.1 µg/L	4.3 µg/L 3.9 µg/L
FOLR2	Folate receptor beta	4.0 µg/L	4.0 µg/L
FAM3B	FAM3 metabolism regulating signaling molecule B	2.1 µg/L	4.0 µg/L 150 ng/L
ADAM28	ADAM metallopeptidase domain 28	3.7 µg/L	3.7 µg/L
GNLY	Granulysin	2.9 µg/L	3.7 µg/L 2.6 µg/L 2.5 µg/L
TNFRSF1B	TNF receptor superfamily member 1B	3.2 µg/L	4.0 µg/L 3.7 µg/L 2.0 µg/L
F7	Coagulation factor VII	350 µg/L	700 µg/L 3.6 µg/L
ERAP1	Endoplasmic reticulum aminopeptidase 1	3.5 µg/L	3.5 µg/L
RNASE3	Ribonuclease A family member 3	4.2 µg/L	4.6 µg/L 4.5 µg/L 3.5 µg/L
CCL15	C-C motif chemokine ligand 15	3.3 µg/L	3.3 µg/L
CLEC18A	C-type lectin domain family 18 member A	3.1 µg/L	3.1 µg/L
LGALS1	Galectin 1	10 µg/L	18 µg/L 8.9 µg/L 3.1 µg/L
CMA1	Chymase 1	3.0 µg/L	3.0 µg/L
S100A8	S100 calcium binding protein A8	11 µg/L	21 µg/L 19 µg/L 3.0 µg/L 510 ng/L
C17orf99	Chromosome 17 open reading frame 99	2.2 µg/L	2.9 µg/L 1.5 µg/L
ANGPTL2	Angiopoietin like 2	2.5 µg/L	2.5 µg/L
IL18BP	Interleukin 18 binding protein	3.1 µg/L	5.8 µg/L 2.5 µg/L 920 ng/L
NPTX2	Neuronal pentraxin 2	2.5 µg/L	2.5 µg/L
AGT	Angiotensinogen	5.9 µg/L	7.9 µg/L 7.5 µg/L 2.4 µg/L
FLT1	Fms related receptor tyrosine kinase 1	880 ng/L	2.4 µg/L 140 ng/L 79 ng/L
TNFSF15	TNF superfamily member 15	1.1 µg/L	2.2 µg/L 610 ng/L 530 ng/L
NUCB2	Nucleobindin 2	1.2 µg/L	2.1 µg/L 360 ng/L
AMH	Anti-Mullerian hormone	1.6 µg/L	2.1 µg/L 1.1 µg/L
GHR	Growth hormone receptor	2.2 µg/L	2.3 µg/L 2.1 µg/L
TFF3	Trefoil factor 3	150 µg/L	280 µg/L 170 µg/L 2.1 µg/L
HAMP	Hepcidin antimicrobial peptide	1.9 µg/L	1.9 µg/L
SCUBE3	Signal peptide, CUB domain and EGF like domain containing 3	1.9 µg/L	1.9 µg/L
CD48	CD48 molecule	1.8 µg/L	1.8 µg/L 1.7 µg/L
ANXA1	Annexin A1	18 µg/L	33 µg/L 1.7 µg/L
ASGR1	Asialoglycoprotein receptor 1	1.7 µg/L	1.7 µg/L
SEMA3F	Semaphorin 3F	1.7 µg/L	1.7 µg/L
GH1	Growth hormone 1	2.7 µg/L	4.0 µg/L 3.3 µg/L 1.8 µg/L 1.7 µg/L
OXT	Oxytocin/neurophysin I prepropeptide	1.5 µg/L	1.5 µg/L
GDF15	Growth differentiation factor 15	1.3 µg/L	1.4 µg/L 1.3 µg/L 1.1 µg/L
VGF	VGF nerve growth factor inducible	1.3 µg/L	1.3 µg/L
FST	Follistatin	1.3 µg/L	1.4 µg/L 1.3 µg/L 1.2 µg/L
HTRA1	HtrA serine peptidase 1	25 µg/L	48 µg/L 1.2 µg/L
ITIH4	Inter-alpha-trypsin inhibitor heavy chain 4	3.1 µg/L	5.7 µg/L 2.4 µg/L 1.1 µg/L
PTX3	Pentraxin 3	1.1 µg/L	1.1 µg/L 1.1 µg/L
C1QTNF2	C1q and TNF related 2	1.1 µg/L	1.1 µg/L
F12	Coagulation factor XII	1.0 µg/L	1.0 µg/L
EMC10	ER membrane protein complex subunit 10	1.0 µg/L	1.0 µg/L
IL22RA2	Interleukin 22 receptor subunit alpha 2	41 µg/L	80 µg/L 1.0 µg/L
PLA2G2A	Phospholipase A2 group IIA	1.0 µg/L	1.0 µg/L
TNFSF13B	TNF superfamily member 13b	390 ng/L	970 ng/L 210 ng/L 2.4 ng/L
ESM1	Endothelial cell specific molecule 1	1.5 µg/L	2.1 µg/L 1.6 µg/L 910 ng/L
INSL3	Insulin like 3	570 ng/L	900 ng/L 690 ng/L 110 ng/L
ANGPTL8	Angiopoietin like 8	840 ng/L	870 ng/L 800 ng/L
VEGFC	Vascular endothelial growth factor C	380 ng/L	820 ng/L 200 ng/L 120 ng/L
CXCL14	C-X-C motif chemokine ligand 14	800 ng/L	800 ng/L
CD40	CD40 molecule	710 ng/L	790 ng/L 620 ng/L
EFNA1	Ephrin A1	790 ng/L	790 ng/L
CSF1	Colony stimulating factor 1	270 ng/L	770 ng/L 280 ng/L 220 ng/L 40 ng/L 40 ng/L
CXCL1	C-X-C motif chemokine ligand 1	380 ng/L	1.1 µg/L 750 ng/L 620 ng/L 340 ng/L 120 ng/L 120 ng/L 60 ng/L 2.0 ng/L
ACP3	Acid phosphatase 3	460 ng/L	730 ng/L 190 ng/L
REN	Renin	690 ng/L	690 ng/L
CD40LG	CD40 ligand	780 ng/L	2.1 µg/L 690 ng/L 530 ng/L 450 ng/L 79 ng/L
C4orf48	Chromosome 4 open reading frame 48	680 ng/L	680 ng/L
CD160	CD160 molecule	3.1 µg/L	5.6 µg/L 670 ng/L
KL	Klotho	510 ng/L	630 ng/L 520 ng/L 380 ng/L
TNFSF12	TNF superfamily member 12	850 ng/L	1.6 µg/L 600 ng/L 310 ng/L
TGFB2	Transforming growth factor beta 2	4.9 µg/L	14 µg/L 590 ng/L 590 ng/L
ANGPT2	Angiopoietin 2	3.8 µg/L	9.5 µg/L 3.8 µg/L 2.6 µg/L 2.3 µg/L 570 ng/L
NAMPT	Nicotinamide phosphoribosyltransferase	2.1 µg/L	3.7 µg/L 570 ng/L
CCL22	C-C motif chemokine ligand 22	620 ng/L	1.1 µg/L 560 ng/L 440 ng/L 380 ng/L
CXCL2	C-X-C motif chemokine ligand 2	500 ng/L	500 ng/L
CCL2	C-C motif chemokine ligand 2	320 ng/L	500 ng/L 410 ng/L 390 ng/L 180 ng/L 140 ng/L
CXCL16	C-X-C motif chemokine ligand 16	1.1 µg/L	2.4 µg/L 500 ng/L 450 ng/L
CXCL11	C-X-C motif chemokine ligand 11	190 ng/L	500 ng/L 50 ng/L 12 ng/L
CCL16	C-C motif chemokine ligand 16	2.8 µg/L	5.4 µg/L 4.2 µg/L 1.0 µg/L 500 ng/L
MLN	Motilin	450 ng/L	450 ng/L
IFNA2	Interferon alpha 2	250 ng/L	440 ng/L 68 ng/L
SPX	Spexin hormone	2.7 µg/L	6.6 µg/L 900 ng/L 420 ng/L
TNFRSF6B	TNF receptor superfamily member 6b	410 ng/L	740 ng/L 410 ng/L 64 ng/L
VEGFD	Vascular endothelial growth factor D	590 ng/L	1.5 µg/L 410 ng/L 230 ng/L 230 ng/L
FOLR1	Folate receptor alpha	450 ng/L	490 ng/L 400 ng/L
FGL1	Fibrinogen like 1	34 µg/L	100 µg/L 690 ng/L 400 ng/L
CCL27	C-C motif chemokine ligand 27	440 ng/L	560 ng/L 390 ng/L 360 ng/L
POMC	Proopiomelanocortin	380 ng/L	380 ng/L 380 ng/L
FGF21	Fibroblast growth factor 21	250 ng/L	380 ng/L 130 ng/L
PLAU	Plasminogen activator, urokinase	650 ng/L	790 ng/L 780 ng/L 370 ng/L
VEGFA	Vascular endothelial growth factor A	560 ng/L	1.3 µg/L 560 ng/L 340 ng/L 93 ng/L
CXCL13	C-X-C motif chemokine ligand 13	94 ng/L	310 ng/L 61 ng/L 44 ng/L 29 ng/L 22 ng/L
BTC	Betacellulin	310 ng/L	320 ng/L 310 ng/L
CCL4	C-C motif chemokine ligand 4	140 ng/L	300 ng/L 210 ng/L 110 ng/L 69 ng/L 26 ng/L
HGFAC	HGF activator	7.6 µg/L	18 µg/L 4.9 µg/L 280 ng/L
INS	Insulin	440 ng/L	800 ng/L 280 ng/L 240 ng/L
ERFE	Erythroferrone	280 ng/L	280 ng/L
CCL19	C-C motif chemokine ligand 19	200 ng/L	290 ng/L 270 ng/L 23 ng/L
AGGF1	Angiogenic factor with G-patch and FHA domains 1	270 ng/L	270 ng/L
CX3CL1	C-X3-C motif chemokine ligand 1	1.9 µg/L	3.5 µg/L 250 ng/L
IL19	Interleukin 19	170 ng/L	250 ng/L 250 ng/L 16 ng/L
IL18	Interleukin 18	200 ng/L	310 ng/L 260 ng/L 240 ng/L 100 ng/L 60 ng/L
CXCL5	C-X-C motif chemokine ligand 5	1.1 µg/L	2.2 µg/L 1.8 µg/L 880 ng/L 420 ng/L 240 ng/L
CXCL6	C-X-C motif chemokine ligand 6	110 ng/L	240 ng/L 53 ng/L 32 ng/L
VEGFB	Vascular endothelial growth factor B	190 ng/L	230 ng/L 140 ng/L
CXCL9	C-X-C motif chemokine ligand 9	900 ng/L	2.1 µg/L 990 ng/L 790 ng/L 430 ng/L 230 ng/L
EBI3	Epstein-Barr virus induced 3	200 ng/L	200 ng/L
CCL13	C-C motif chemokine ligand 13	340 ng/L	600 ng/L 410 ng/L 380 ng/L 200 ng/L 92 ng/L
CCL24	C-C motif chemokine ligand 24	280 ng/L	360 ng/L 270 ng/L 200 ng/L
PDGFB	Platelet derived growth factor subunit B	4.4 µg/L	18 µg/L 2.7 µg/L 520 ng/L 260 ng/L 190 ng/L
UTS2	Urotensin 2	2.6 µg/L	7.6 µg/L 180 ng/L 970 pg/L
IFNL1	Interferon lambda 1	97 ng/L	170 ng/L 110 ng/L 11 ng/L
SCUBE1	Signal peptide, CUB domain and EGF like domain containing 1	2.2 µg/L	8.6 µg/L 1.2 µg/L 1.2 µg/L 1.1 µg/L 740 ng/L 150 ng/L
CXCL10	C-X-C motif chemokine ligand 10	250 ng/L	440 ng/L 390 ng/L 250 ng/L 150 ng/L 28 ng/L
ANGPTL6	Angiopoietin like 6	450 ng/L	760 ng/L 140 ng/L
UCN	Urocortin	130 ng/L	130 ng/L
MDK	Midkine	160 ng/L	190 ng/L 160 ng/L 130 ng/L
IL1F10	Interleukin 1 family member 10	220 ng/L	320 ng/L 120 ng/L
RETNLB	Resistin like beta	120 ng/L	120 ng/L
IL34	Interleukin 34	57 ng/L	120 ng/L 41 ng/L 10 ng/L
ADM2	Adrenomedullin 2	61 ng/L	120 ng/L 5.0 ng/L
PTN	Pleiotrophin	170 ng/L	220 ng/L 120 ng/L
IL20	Interleukin 20	110 ng/L	200 ng/L 110 ng/L 13 ng/L
METRNL	Meteorin like, glial cell differentiation regulator	440 ng/L	1.1 µg/L 110 ng/L 95 ng/L
IL36RN	Interleukin 36 receptor antagonist	110 ng/L	110 ng/L
IL16	Interleukin 16	210 ng/L	370 ng/L 300 ng/L 190 ng/L 100 ng/L 88 ng/L
FASLG	Fas ligand	74 ng/L	100 ng/L 87 ng/L 85 ng/L 22 ng/L
BMP6	Bone morphogenetic protein 6	5.0 µg/L	14 µg/L 880 ng/L 100 ng/L
UCN2	Urocortin 2	99 ng/L	99 ng/L
LGALS9	Galectin 9	450 ng/L	1.2 µg/L 98 ng/L 47 ng/L
PMCH	Pro-melanin concentrating hormone	270 ng/L	450 ng/L 98 ng/L
IL13	Interleukin 13	40 ng/L	98 ng/L 49 ng/L 49 ng/L 2.3 ng/L 1.4 ng/L
FGF19	Fibroblast growth factor 19	130 ng/L	170 ng/L 98 ng/L
CCL23	C-C motif chemokine ligand 23	940 ng/L	1.5 µg/L 1.2 µg/L 91 ng/L
VIP	Vasoactive intestinal peptide	120 ng/L	150 ng/L 89 ng/L
IL36A	Interleukin 36 alpha	250 ng/L	890 ng/L 88 ng/L 13 ng/L 4.2 ng/L
CCL21	C-C motif chemokine ligand 21	200 ng/L	480 ng/L 87 ng/L 29 ng/L
GUCA2B	Guanylate cyclase activator 2B	78 ng/L	82 ng/L 73 ng/L
PYY	Peptide YY	87 ng/L	120 ng/L 99 ng/L 82 ng/L 49 ng/L
FLT3LG	Fms related receptor tyrosine kinase 3 ligand	80 ng/L	80 ng/L
GCG	Glucagon	130 ng/L	230 ng/L 80 ng/L 76 ng/L
F3	Coagulation factor III, tissue factor	600 ng/L	1.4 µg/L 770 ng/L 220 ng/L 75 ng/L
IL1R2	Interleukin 1 receptor type 2	7.1 µg/L	11 µg/L 10 µg/L 69 ng/L
HBEGF	Heparin binding EGF like growth factor	120 ng/L	300 ng/L 110 ng/L 93 ng/L 63 ng/L 16 ng/L
IL25	Interleukin 25	35 ng/L	90 ng/L 55 ng/L 21 ng/L 6.1 ng/L 3.1 ng/L
CCL3	C-C motif chemokine ligand 3	140 ng/L	290 ng/L 280 ng/L 150 ng/L 61 ng/L 54 ng/L 4.6 ng/L
S100A9	S100 calcium binding protein A9	11 µg/L	25 µg/L 8.9 µg/L 8.4 µg/L 52 ng/L
CCL11	C-C motif chemokine ligand 11	89 ng/L	180 ng/L 99 ng/L 63 ng/L 52 ng/L 50 ng/L
EREG	Epiregulin	46 ng/L	51 ng/L 41 ng/L
IL21	Interleukin 21	56 ng/L	66 ng/L 51 ng/L 50 ng/L
IL12B	Interleukin 12B	140 ng/L	200 ng/L 170 ng/L 50 ng/L
IL24	Interleukin 24	140 ng/L	270 ng/L 100 ng/L 50 ng/L
NPY	Neuropeptide Y	31 µg/L	72 µg/L 26 µg/L 25 µg/L 45 ng/L
PTH	Parathyroid hormone	28 ng/L	44 ng/L 12 ng/L
FGF23	Fibroblast growth factor 23	57 ng/L	71 ng/L 43 ng/L
IL31	Interleukin 31	38 ng/L	53 ng/L 42 ng/L 19 ng/L
TNFSF10	TNF superfamily member 10	67 ng/L	120 ng/L 43 ng/L 42 ng/L
IL27	Interleukin 27	520 ng/L	1.0 µg/L 42 ng/L
GDF11	Growth differentiation factor 11	46 ng/L	53 ng/L 40 ng/L
TGFB1	Transforming growth factor beta 1	1.3 µg/L	3.7 µg/L 120 ng/L 40 ng/L
IL17C	Interleukin 17C	30 ng/L	40 ng/L 21 ng/L
IL17B	Interleukin 17B	75 ng/L	110 ng/L 40 ng/L
OSM	Oncostatin M	40 ng/L	40 ng/L
IL32	Interleukin 32	46 ng/L	94 ng/L 39 ng/L 4.6 ng/L
ADM	Adrenomedullin	31 ng/L	39 ng/L 23 ng/L
GIP	Gastric inhibitory polypeptide	34 ng/L	39 ng/L 29 ng/L
THPO	Thrombopoietin	1.1 µg/L	2.7 µg/L 2.5 µg/L 49 ng/L 44 ng/L 39 ng/L
IL4R	Interleukin 4 receptor	39 ng/L	39 ng/L
IL36G	Interleukin 36 gamma	37 ng/L	37 ng/L
IL1RN	Interleukin 1 receptor antagonist	290 ng/L	680 ng/L 550 ng/L 120 ng/L 68 ng/L 35 ng/L
CXCL12	C-X-C motif chemokine ligand 12	1.0 µg/L	2.0 µg/L 33 ng/L
PPY	Pancreatic polypeptide	70 ng/L	110 ng/L 87 ng/L 76 ng/L 50 ng/L 32 ng/L
CKLF	Chemokine like factor	32 ng/L	32 ng/L
IL26	Interleukin 26	36 ng/L	45 ng/L 33 ng/L 30 ng/L
IL37	Interleukin 37	77 ng/L	120 ng/L 85 ng/L 30 ng/L
CXCL3	C-X-C motif chemokine ligand 3	29 ng/L	29 ng/L
TNFSF11	TNF superfamily member 11	17 ng/L	29 ng/L 5.8 ng/L
TGFB3	Transforming growth factor beta 3	45 ng/L	62 ng/L 28 ng/L
BMP7	Bone morphogenetic protein 7	250 ng/L	470 ng/L 27 ng/L
TNFSF14	TNF superfamily member 14	41 ng/L	55 ng/L 42 ng/L 26 ng/L
IL9	Interleukin 9	11 ng/L	26 ng/L 5.6 ng/L 1.2 ng/L
IL17D	Interleukin 17D	25 ng/L	25 ng/L
CCL17	C-C motif chemokine ligand 17	250 ng/L	700 ng/L 24 ng/L 21 ng/L
MYDGF	Myeloid derived growth factor	280 ng/L	650 ng/L 180 ng/L 21 ng/L
IL17F	Interleukin 17F	30 ng/L	40 ng/L 20 ng/L
CCL8	C-C motif chemokine ligand 8	32 ng/L	50 ng/L 36 ng/L 35 ng/L 21 ng/L 19 ng/L
GAL	Galanin and GMAP prepropeptide	60 ng/L	100 ng/L 19 ng/L
TNFRSF1A	TNF receptor superfamily member 1A	18 ng/L	18 ng/L
BMP2	Bone morphogenetic protein 2	24 ng/L	35 ng/L 21 ng/L 17 ng/L
IL36B	Interleukin 36 beta	8.6 ng/L	15 ng/L 1.8 ng/L
PGF	Placental growth factor	21 ng/L	41 ng/L 26 ng/L 19 ng/L 15 ng/L 3.6 ng/L
IL15	Interleukin 15	180 ng/L	430 ng/L 420 ng/L 43 ng/L 15 ng/L 4.1 ng/L
IL3	Interleukin 3	18 ng/L	30 ng/L 30 ng/L 15 ng/L 14 ng/L 200 pg/L
LTA	Lymphotoxin alpha	8.2 ng/L	13 ng/L 8.5 ng/L 2.8 ng/L
IL4	Interleukin 4	14 ng/L	28 ng/L 18 ng/L 13 ng/L 8.0 ng/L 400 pg/L
IL11	Interleukin 11	35 ng/L	68 ng/L 25 ng/L 12 ng/L
IAPP	Islet amyloid polypeptide	610 ng/L	1.2 µg/L 12 ng/L
SERPINF2	Serpin family F member 2	12 ng/L	12 ng/L
CTF1	Cardiotrophin 1	12 ng/L	12 ng/L
IL23A	Interleukin 23 subunit alpha	11 ng/L	11 ng/L
TSLP	Thymic stromal lymphopoietin	38 ng/L	66 ng/L 11 ng/L
PNOC	Prepronociceptin	12 ng/L	14 ng/L 11 ng/L
CRH	Corticotropin releasing hormone	10 ng/L	10 ng/L
IFNA1	Interferon alpha 1	10 ng/L	10 ng/L
CCL26	C-C motif chemokine ligand 26	120 ng/L	330 ng/L 180 ng/L 49 ng/L 17 ng/L 9.0 ng/L
BMP10	Bone morphogenetic protein 10	8.1 ng/L	8.1 ng/L
EPO	Erythropoietin	12 ng/L	17 ng/L 8.0 ng/L
IL1A	Interleukin 1 alpha	11 ng/L	26 ng/L 10 ng/L 10 ng/L 8.0 ng/L 200 pg/L
IL7	Interleukin 7	61 ng/L	190 ng/L 55 ng/L 51 ng/L 7.5 ng/L 2.8 ng/L
CCL20	C-C motif chemokine ligand 20	28 ng/L	83 ng/L 37 ng/L 6.9 ng/L 6.6 ng/L 6.4 ng/L
CSF3	Colony stimulating factor 3	6.2 ng/L	6.6 ng/L 5.7 ng/L
CCL1	C-C motif chemokine ligand 1	84 ng/L	270 ng/L 110 ng/L 26 ng/L 6.4 ng/L 2.0 ng/L
NPPB	Natriuretic peptide B	9.7 ng/L	13 ng/L 10 ng/L 9.3 ng/L 6.2 ng/L
IL10	Interleukin 10	5.7 ng/L	7.5 ng/L 6.6 ng/L 6.0 ng/L 5.0 ng/L 3.3 ng/L
EDN3	Endothelin 3	31 ng/L	56 ng/L 5.8 ng/L
TGFA	Transforming growth factor alpha	58 ng/L	150 ng/L 21 ng/L 5.6 ng/L
CXCL8	C-X-C motif chemokine ligand 8	7.3 ng/L	10 ng/L 7.3 ng/L 7.3 ng/L 6.0 ng/L 5.6 ng/L
CSF2	Colony stimulating factor 2	24 ng/L	67 ng/L 16 ng/L 7.3 ng/L 5.5 ng/L
IL1B	Interleukin 1 beta	2.3 ng/L	5.0 ng/L 3.6 ng/L 1.6 ng/L 1.1 ng/L 450 pg/L
IL22	Interleukin 22	87 ng/L	250 ng/L 6.2 ng/L 4.6 ng/L
CALCB	Calcitonin related polypeptide beta	4.5 ng/L	4.5 ng/L
SCT	Secretin	570 ng/L	1.1 µg/L 630 ng/L 4.4 ng/L
IL5	Interleukin 5	4.1 ng/L	5.8 ng/L 5.1 ng/L 4.9 ng/L 4.4 ng/L 430 pg/L
IFNB1	Interferon beta 1	3.8 ng/L	4.4 ng/L 3.1 ng/L
RLN2	Relaxin 2	24 ng/L	46 ng/L 3.1 ng/L
NPPC	Natriuretic peptide C	6.1 ng/L	13 ng/L 2.7 ng/L 2.5 ng/L
CCL7	C-C motif chemokine ligand 7	30 ng/L	94 ng/L 30 ng/L 21 ng/L 2.5 ng/L 1.2 ng/L
IL2	Interleukin 2	20 ng/L	45 ng/L 20 ng/L 20 ng/L 14 ng/L 2.4 ng/L
GZMB	Granzyme B	2.2 ng/L	2.2 ng/L
CALCA	Calcitonin related polypeptide alpha	50 ng/L	190 ng/L 42 ng/L 9.3 ng/L 4.8 ng/L 2.0 ng/L
IFNL3	Interferon lambda 3	1.7 ng/L	2.0 ng/L 1.4 ng/L
EDN1	Endothelin 1	9.7 ng/L	27 ng/L 1.4 ng/L 800 pg/L
TNF	Tumor necrosis factor	10 ng/L	15 ng/L 14 ng/L 1.3 ng/L
IL6	Interleukin 6	5.7 ng/L	12 ng/L 5.4 ng/L 5.1 ng/L 4.8 ng/L 1.2 ng/L
AVP	Arginine vasopressin	19 ng/L	38 ng/L 920 pg/L
IL17A	Interleukin 17A	9.9 ng/L	20 ng/L 200 pg/L
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