Pediatric retinoblastoma

Retinoblastoma is a malignant tumor that arises in the developing retina of young children. It can occur in one or both eyes, with bilateral cases often linked to genetic factors. Typically, the tumor is diagnosed before the age of three, as parents may observe differences in the child's pupils or signs of leukocoria (a white reflection in the pupil) or strabismus (crossed eyes).

The treatment approach for retinoblastoma varies based on the tumor's size and stage. Common modalities include chemotherapy, radiation therapy, and in some cases surgical intervention. The prognosis is generally favorable, with high survival rates; most children retain good vision in at least one eye.

NIH - Retinoblastoma

Differential Abundance Analysis Results

This section presents the results of the differential protein abundance analysis, visualized through a volcano plot and summarized in the accompanying table for all three comparisons: 1) disease vs. healthy samples, 2) disease vs. diseases from the same class, and 3) disease vs. all other diseases.

Disease vs Healthy
Disease vs Class
Disease vs All other