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Pediatric kidney tumor Pediatric kidney tumorWilms tumor, also known as nephroblastoma, is a renal malignancy predominantly affecting children under the age of five. The etiology of Wilms tumor remains incompletely understood; however, it is associated with genetic predispositions, including family history, congenital malformations, and specific genetic syndromes. The most common symptom is an abdominal mass or swelling. Some children may present with hematuria, fever, gastrointestinal symptoms, weight loss or blood in the urine. Management typically involves a multimodal approach, including surgical resection, chemotherapy, and, in some cases, radiotherapy, tailored to the tumor's stage and characteristics. The prognosis for Wilms tumor is generally favorable, with high survival rates, particularly in cases diagnosed at an early stage. Regular follow-up is essential for monitoring potential long-term effects and recurrence. Differential Abundance Analysis ResultsThis section presents the results of the differential protein abundance analysis, visualized through a volcano plot and summarized in the accompanying table for all three comparisons: 1) disease vs. healthy samples, 2) disease vs. diseases from the same class, and 3) disease vs. all other diseases. Disease vs Healthy
Disease vs Class
Disease vs All other
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
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The Project
The Human Protein Atlas
The Human Protein Atlas project is funded
