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Multiple sclerosis Multiple sclerosisMultiple sclerosis (MS) is a chronic and debilitating autoimmune disease with neurodegenerative properties (Haki M et al. (2024)). It is a heterogeneous disease with inflammatory effects on the central nervous system that can cause demyelination and neuronal loss (Doshi A et al. (2016)). There are multiple types of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) (Haki M et al. (2024)). As with other autoimmune diseases, females are more likely to be diagnosed than males. Smoking is a risk factor that can increase the chance of MS by up to 50% (Dobson R et al. (2019)). Diagnosis occurs between 20 and 50 years of age, and those of northern European descent have a higher risk of developing the disease (Haki M et al. (2024)). Differential Abundance Analysis ResultsThis section presents the results of the differential protein abundance analysis, visualized through a volcano plot and summarized in the accompanying table for all three comparisons: 1) disease vs. healthy samples, 2) disease vs. diseases from the same class, and 3) disease vs. all other diseases. Disease vs Healthy
Disease vs Class
Disease vs All other
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
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The Project
The Human Protein Atlas
The Human Protein Atlas project is funded
