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Diffuse large B-cell lymphoma Diffuse large B-cell lymphomaDiffuse large B-cell lymphoma (DLBCL) is a cancer affecting the B cells, a type of lymphocyte that is responsible for producing antibodies. These cancerous white blood cells enlarge the lymph nodes and frequently migrate to the spleen, liver, bone marrow, and other organs. It is derived from white blood cells that grow in an uncontrolled, rapid manner. It is the most common form of lymphoma, comprising 25-30% of non-Hodgkin lymphomas (Padala SA et al. (2024)). This cancer occurs primarily in older individuals, although it can occur in young adults and, in rare cases, children. DLBCL can arise in virtually any part of the body and is often an aggressive malignancy. The main treatment includes chemoimmunotherapy, a combination of chemotherapy, steroids, and a targeted cancer drug (CRUK - Diffuse large B cell lymphoma). Differential Abundance Analysis ResultsThis section presents the results of the differential protein abundance analysis, visualized through a volcano plot and summarized in the accompanying table for all three comparisons: 1) disease vs. healthy samples, 2) disease vs. diseases from the same class, and 3) disease vs. all other diseases. Disease vs Healthy
Disease vs Class
Disease vs All other
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
Figure 1: In the volcano plot, proteins are plotted based on their fold change (logFC) on the x-axis and the statistical significance of the change (-log10 adjusted p-value) on the y-axis. Proteins considered differentially abundant are highlighted, defined by an adjusted p-value < 0.05 and an absolute logFC > 0.5.
Table 1: The summary table lists the results for all comparisons, sorted by p-value by default. It includes key metrics such as fold change and adjusted p-value, to allow exploration of the most significant proteins for each comparison.
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The Human Protein Atlas
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