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                                          • PRODH2
                                          TISSUE PRIMARY DATA KIDNEY Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
                                          DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
                                          NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
                                          SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
                                          ANTIBODIES
                                          AND
                                          VALIDATION
                                          Dictionary
                                          Kidney
                                          Tissue proteome
                                          Kidney
                                          Tissue methods
                                          KIDNEY - Expression summary
                                          Protein expression
                                          Kidneyi

                                          On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

                                          h
                                          m
                                          l
                                          n
                                          Cells in glomeruli: Not detected
                                          Cells in tubules: High
                                          RNA expressioni

                                          A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

                                          Scroll down to view mRNA expression data in more detail.

                                          Consensus:154.3 nTPM
                                          HPA:129.8 nTPM
                                          GTEx:154.3 nTPM
                                          FANTOM5:33.0 Scaled Tags Per Million
                                          KIDNEY - SINGLE CELL RNA EXPRESSION
                                          Explore single cell type data
                                          Renal collecting duct intercalated cellsRenal collecting duct principal cellsRenal connecting tubule cellsPodocytesProximal tubule cellsLoop of henle epithelial cellsPapillary tip epithelial cellsDistal convoluted tubule cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMacrophagesT-cellsB-cellsNK-cells050100150200250300350nCPM

                                          KIDNEY - Antibody stainingi

                                          Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

                                          Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

                                          Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

                                          Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

                                          Antibody HPA051287
                                          Cells in glomeruli Not detected
                                          Cells in tubules High



                                          KIDNEY - HPA RNA-seqi

                                          The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

                                          Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

                                          Average nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          129.8
                                          overview
                                          Female, age 58
                                          Kidney sample 55
                                          nTPM: 238.3
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          20

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 67
                                          Kidney sample 56
                                          nTPM: 266.6
                                          Cell types%
                                          Cells in tubules:
                                          70

                                          Cells in glomeruli:
                                          15

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          5

                                          overview
                                          Female, age 55
                                          Kidney sample 57
                                          nTPM: 61.9
                                          Cell types%
                                          Cells in tubules:
                                          80

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          5

                                          overview
                                          Male, age 46
                                          Kidney sample 58
                                          nTPM: 301
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          25

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          10

                                          overview
                                          Female, age 57
                                          Kidney sample 358
                                          nTPM: 30.4
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 78
                                          Kidney sample 377
                                          nTPM: 34
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 73
                                          Kidney sample 380
                                          nTPM: 158.3
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Female, age 59
                                          Kidney sample 394
                                          nTPM: 51.3
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 48
                                          Kidney sample 414
                                          nTPM: 26.1
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          5

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          25


                                          KIDNEY - GTEx RNA-seqi

                                          RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

                                          Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

                                          Max subtype nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          154.3
                                          GTEx sample id Sample description nTPM
                                          41.0113.8223.00.2491.0050100150200250300350400450500550600650
                                          41.0113.8223.00.2491.0050100150200250300350400450500550600650
                                          Kidney - Cortex
                                          Average nTPM: 154.3
                                          Samples: 104

                                          Max nTPM: 683.0
                                          Min nTPM: 0.2
                                          Std nTPM: 148.9
                                          Median nTPM: 113.8
                                          GTEX-13NYB-1726-SM-5N9G2 40-49 years, male 683.0
                                          GTEX-13OW6-1826-SM-5N9F9 50-59 years, male 560.3
                                          GTEX-T6MN-1826-SM-EXOHN 50-59 years, male 553.7
                                          GTEX-QDT8-1726-SM-EYYV6 30-39 years, female 502.2
                                          GTEX-1RQEC-2426-SM-F2I1J 60-69 years, male 491.0
                                          GTEX-1GF9W-1326-SM-7P8PX 60-69 years, male 474.4
                                          GTEX-15DYW-2026-SM-6AJBD 60-69 years, female 459.4
                                          GTEX-T5JC-1526-SM-4DM68 20-29 years, male 416.3
                                          GTEX-1JMQJ-1726-SM-E9U4V 50-59 years, male 406.3
                                          GTEX-17HHY-2326-SM-7KFSR 50-59 years, male 396.0
                                          GTEX-WL46-1926-SM-GNIN6 50-59 years, male 391.1
                                          GTEX-14JG1-2326-SM-HAUZ5 40-49 years, male 382.3
                                          GTEX-1KWVE-0826-SM-CXZKO 30-39 years, male 369.5
                                          GTEX-1HBPI-2026-SM-CE6RZ 50-59 years, male 329.0
                                          GTEX-14E6D-2526-SM-5YYA9 50-59 years, male 319.1
                                          GTEX-1117F-2126-SM-GIN9G 60-69 years, female 315.7
                                          GTEX-1IKK5-0926-SM-A9G2U 60-69 years, male 293.2
                                          GTEX-1NV8Z-2226-SM-EXOJ2 60-69 years, male 292.5
                                          GTEX-1BAJH-1826-SM-731DA 70-79 years, male 286.5
                                          GTEX-1HCVE-2126-SM-HL9UO 50-59 years, male 278.6
                                          GTEX-1GF9V-1926-SM-9JGHE 60-69 years, male 274.4
                                          GTEX-Y5V5-1226-SM-EYYVP 60-69 years, female 252.3
                                          GTEX-REY6-1826-SM-EAZAT 60-69 years, male 233.4
                                          GTEX-1GMR3-2426-SM-7MXV2 40-49 years, male 229.8
                                          GTEX-16MT8-1926-SM-7EPGL 60-69 years, female 224.0
                                          GTEX-1O9I2-1926-SM-F2TBQ 50-59 years, male 223.7
                                          GTEX-ZC5H-1726-SM-5HL7X 40-49 years, female 222.8
                                          GTEX-1JJ6O-2526-SM-AHZ3J 60-69 years, male 217.3
                                          GTEX-11OF3-1326-SM-5N9FJ 60-69 years, male 211.4
                                          GTEX-1H3NZ-2126-SM-9WPQ6 60-69 years, male 204.5
                                          GTEX-P4QS-1126-SM-3NMD5 60-69 years, male 203.2
                                          GTEX-1JMPZ-1226-SM-ARU8Y 30-39 years, male 197.1
                                          GTEX-1ICLY-2026-SM-GA913 50-59 years, male 179.6
                                          GTEX-16Z82-2826-SM-HAUZZ 60-69 years, male 178.1
                                          GTEX-S33H-1426-SM-EZ6L7 30-39 years, male 177.8
                                          GTEX-14C5O-2026-SM-5YYB1 60-69 years, male 169.0
                                          GTEX-1JMLX-1526-SM-AHZ3N 50-59 years, male 164.2
                                          GTEX-NFK9-1826-SM-HL9T3 40-49 years, male 164.1
                                          GTEX-1R9PO-1626-SM-E6CPT 60-69 years, female 159.0
                                          GTEX-1IL2V-1826-SM-ARU7R 70-79 years, male 148.7
                                          GTEX-14PJ2-1826-SM-HL9UB 50-59 years, male 148.4
                                          GTEX-16XZZ-2226-SM-HAV34 60-69 years, male 142.3
                                          GTEX-1HB9E-1826-SM-D4P33 50-59 years, male 141.7
                                          GTEX-1A8FM-2026-SM-7P8RN 50-59 years, female 139.3
                                          GTEX-Y5V6-2026-SM-5IFHO 60-69 years, male 134.9
                                          GTEX-1E2YA-1626-SM-7MGXS 50-59 years, male 134.1
                                          GTEX-1JJE9-1026-SM-HL9TH 70-79 years, male 132.4
                                          GTEX-13FHP-2126-SM-GIN8J 50-59 years, male 132.2
                                          GTEX-15CHQ-2126-SM-6871M 60-69 years, male 129.3
                                          GTEX-15DCD-1926-SM-HAV33 70-79 years, female 128.3
                                          GTEX-1HCU7-1826-SM-A9G2A 50-59 years, male 125.6
                                          GTEX-1I1GP-1926-SM-CNNQU 50-59 years, male 117.5
                                          GTEX-14C39-2126-SM-664OH 40-49 years, male 110.1
                                          GTEX-O5YV-1226-SM-EV795 60-69 years, female 101.9
                                          GTEX-1N2EF-1426-SM-EXUSH 60-69 years, male 95.7
                                          GTEX-1JMQK-1926-SM-CJI3B 60-69 years, male 91.2
                                          GTEX-XPVG-0526-SM-4B65N 50-59 years, male 90.9
                                          GTEX-1EKGG-2226-SM-7IGOA 60-69 years, male 83.3
                                          GTEX-1GN1U-2126-SM-AHZ4J 50-59 years, female 82.3
                                          GTEX-1QAET-2126-SM-F2TBS 50-59 years, male 82.1
                                          GTEX-12WSG-0826-SM-5EQ5A 50-59 years, female 77.9
                                          GTEX-13RTJ-2226-SM-5S2Q1 60-69 years, male 73.5
                                          GTEX-1497J-0826-SM-5NQAJ 60-69 years, male 73.5
                                          GTEX-1K9T9-1826-SM-CXZK2 50-59 years, female 71.0
                                          GTEX-1PWST-2226-SM-EVR3G 70-79 years, male 70.3
                                          GTEX-1QP6S-1526-SM-EXUSG 40-49 years, male 66.8
                                          GTEX-17F96-1926-SM-7MGWY 70-79 years, male 66.3
                                          GTEX-1GTWX-1826-SM-9QEHG 60-69 years, male 62.6
                                          GTEX-QDVN-1726-SM-HL9TO 50-59 years, male 61.9
                                          GTEX-13O1R-2526-SM-5N9FW 60-69 years, male 61.4
                                          GTEX-1J1OQ-1426-SM-AHZ3P 40-49 years, female 59.4
                                          GTEX-13OVI-1126-SM-5KLZF 60-69 years, female 53.7
                                          GTEX-11GS4-2326-SM-5A5KS 60-69 years, male 53.3
                                          GTEX-1C6VQ-2326-SM-7IGN1 50-59 years, male 52.0
                                          GTEX-1H3VY-1926-SM-9JGHJ 50-59 years, male 48.3
                                          GTEX-ZDXO-0226-SM-4WKH7 60-69 years, male 48.3
                                          GTEX-1F48J-2226-SM-7MXTN 50-59 years, female 45.7
                                          GTEX-1LG7Y-2726-SM-D5OVW 50-59 years, male 41.1
                                          GTEX-1AX8Z-2326-SM-731CR 60-69 years, male 40.5
                                          GTEX-145MN-0326-SM-5QGQI 30-39 years, male 36.2
                                          GTEX-1399S-0526-SM-5IJG8 30-39 years, female 32.2
                                          GTEX-16XZY-1026-SM-HAV39 70-79 years, male 29.2
                                          GTEX-13O3O-1726-SM-GJ3RL 60-69 years, female 28.2
                                          GTEX-147F4-2626-SM-5Q5CS 50-59 years, male 27.1
                                          GTEX-17F97-1926-SM-7IGM4 50-59 years, male 26.4
                                          GTEX-1A3MW-2226-SM-73KUX 60-69 years, female 25.8
                                          GTEX-QLQW-1626-SM-CMKFE 30-39 years, male 24.3
                                          GTEX-1MUQO-2526-SM-E9TJN 60-69 years, male 21.8
                                          GTEX-1CB4J-1926-SM-7MGX8 60-69 years, male 16.0
                                          GTEX-ZYFG-1626-SM-5GZYY 60-69 years, female 15.1
                                          GTEX-ZLFU-0926-SM-5P9F8 40-49 years, male 13.8
                                          GTEX-ZVZP-0926-SM-5GIDB 50-59 years, male 12.3
                                          GTEX-1N2DW-1826-SM-EAZ54 50-59 years, male 10.4
                                          GTEX-13OVL-1826-SM-5KLZR 50-59 years, male 10.0
                                          GTEX-W5X1-1626-SM-H7OGO 40-49 years, female 6.4
                                          GTEX-1OJC4-2326-SM-DTXA5 50-59 years, female 2.6
                                          GTEX-ZYT6-2226-SM-5GIC9 30-39 years, male 2.6
                                          GTEX-11TTK-1926-SM-5PNW8 60-69 years, female 1.4
                                          GTEX-12696-0926-SM-5FQTV 60-69 years, male 1.0
                                          GTEX-13112-2126-SM-5GCO4 50-59 years, male 1.0
                                          GTEX-ZXG5-2026-SM-HAUZV 60-69 years, male 1.0
                                          GTEX-ZE9C-1426-SM-4WKGM 60-69 years, male 0.7
                                          GTEX-RN64-1626-SM-48FD7 50-59 years, male 0.5
                                          GTEX-1LH75-1326-SM-F2I1R 50-59 years, female 0.2
                                          Show allShow less
                                          0.92.175.50.0117.6050100150200250300350400450500
                                          0.92.175.50.0117.6050100150200250300350400450500
                                          Kidney - Medulla
                                          Average nTPM: 79.5
                                          Samples: 11

                                          Max nTPM: 510.8
                                          Min nTPM: 0.0
                                          Std nTPM: 149.8
                                          Median nTPM: 2.1
                                          GTEX-N7MS-1526-SM-HAUZP 60-69 years, male 510.8
                                          GTEX-P4QS-1226-SM-HPAG8 60-69 years, male 201.1
                                          GTEX-RU72-1926-SM-EAZ3F 50-59 years, female 117.6
                                          GTEX-TKQ2-0626-SM-EZ6LB 50-59 years, male 33.5
                                          GTEX-T6MN-1926-SM-GOQYD 50-59 years, male 5.2
                                          GTEX-S33H-1526-SM-GQ1CB 30-39 years, male 2.1
                                          GTEX-QEG4-1526-SM-GPRWK 30-39 years, male 1.5
                                          GTEX-T5JC-1626-SM-EZ6KW 20-29 years, male 1.2
                                          GTEX-SIU8-1926-SM-H7OG4 50-59 years, male 0.7
                                          GTEX-R55E-2026-SM-EZ6L1 20-29 years, male 0.4
                                          GTEX-QEG5-2026-SM-H6Q6I 20-29 years, male 0.0
                                          Show allShow less

                                          KIDNEY - FANTOM5 CAGEi

                                          RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

                                          Max subtype Scaled Tags Per Millioni

                                          Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

                                          33.0
                                          FANTOM5 sample id Sample description Scaled Tags Per Million
                                          Kidney
                                          Scaled Tags Per Million: 33.0
                                          FF:10017-101C8 60,62,63 years, female 33.0

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