GENERAL INFORMATIONi
Gene namei NME2
Synonyms NDPKB, NM23-H2
Gene descriptioni NME/NM23 nucleoside diphosphate kinase 2
Protein classi Cancer-related genes
Enzymes
Metabolic proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband q21.33
Chromosome location (bp) 51165435 - 51171744
Number of transcriptsi 6
Ensembl ENSG00000243678 (version 109)
Entrez gene 4831
HGNC HGNC:7850
UniProt P22392 (UniProt - Evidence at protein level)
neXtProt NX_P22392
GeneCards NME2
Antibodypedia NME2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC 1. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically 2, 3. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) 4. Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not 5. Exhibits histidine protein kinase activity 6. show less
Molecular function (UniProt)i Activator, DNA-binding, Kinase, Transferase
Biological process (UniProt)i Nucleotide metabolism, Transcription, Transcription regulation
Ligand (UniProt)i ATP-binding, Magnesium, Metal-binding, Nucleotide-binding
Gene summary (Entrez)i Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
NME2-201
ENSP00000376880
ENST00000393183
F6XY72
[Direct mapping] HCG2001850, isoform CRA_c; Nucleoside diphosphate kinase B
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 82 aa
9.6 kDa 		No 0
NME2-202
ENSP00000376886
ENST00000393190
P22392
[Direct mapping] Nucleoside diphosphate kinase B
Show all
Q6FHN3
[Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001726 [ruffle]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009117 [nucleotide metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0019003 [GDP binding]
GO:0030027 [lamellipodium]
GO:0034774 [secretory granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1904813 [ficolin-1-rich granule lumen]
Show all
 152 aa
17.3 kDa 		No 0
NME2-204
ENSP00000426901
ENST00000503064
P22392
[Direct mapping] Nucleoside diphosphate kinase B
Show all
Q6FHN3
[Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001726 [ruffle]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009117 [nucleotide metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0019003 [GDP binding]
GO:0030027 [lamellipodium]
GO:0034774 [secretory granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1904813 [ficolin-1-rich granule lumen]
Show all
 152 aa
17.3 kDa 		No 0
NME2-205
ENSP00000421064
ENST00000512737
P22392
[Direct mapping] Nucleoside diphosphate kinase B
Show all
Q6FHN3
[Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001726 [ruffle]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009117 [nucleotide metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0019003 [GDP binding]
GO:0030027 [lamellipodium]
GO:0034774 [secretory granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1904813 [ficolin-1-rich granule lumen]
Show all
 152 aa
17.3 kDa 		No 0
NME2-206
ENSP00000425581
ENST00000513177
P22392
[Direct mapping] Nucleoside diphosphate kinase B
Show all
Q6FHN3
[Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001726 [ruffle]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009117 [nucleotide metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0019003 [GDP binding]
GO:0030027 [lamellipodium]
GO:0034774 [secretory granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1904813 [ficolin-1-rich granule lumen]
Show all
 152 aa
17.3 kDa 		No 0
NME2-207
ENSP00000426976
ENST00000514264
P22392
[Direct mapping] Nucleoside diphosphate kinase B
Show all
Q6FHN3
[Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0001726 [ruffle]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009117 [nucleotide metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0019003 [GDP binding]
GO:0030027 [lamellipodium]
GO:0034774 [secretory granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1904813 [ficolin-1-rich granule lumen]
Show all
 152 aa
17.3 kDa 		No 0

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