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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p22.1
Chromosome location (bp)
29722775 - 29738528
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors 1. Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production 2. Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions 3. May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses 4. May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity 5....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F
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Q5JZ48 [Target identity:100%; Query identity:100%] Major histocompatibility complex, class I, F
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002476[antigen processing and presentation of endogenous peptide antigen via MHC class Ib] GO:0002477[antigen processing and presentation of exogenous peptide antigen via MHC class Ib] GO:0002725[negative regulation of T cell cytokine production] GO:0002728[negative regulation of natural killer cell cytokine production] GO:0002729[positive regulation of natural killer cell cytokine production] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005886[plasma membrane] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0030670[phagocytic vesicle membrane] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0032398[MHC class Ib protein complex] GO:0042605[peptide antigen binding] GO:0042612[MHC class I protein complex] GO:0043322[negative regulation of natural killer cell degranulation] GO:0043323[positive regulation of natural killer cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0055038[recycling endosome membrane] GO:0071889[14-3-3 protein binding] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1901215[negative regulation of neuron death]
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F
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Q5JZ47 [Target identity:100%; Query identity:100%] MHC class I antigen; Major histocompatibility complex, class I, F
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002476[antigen processing and presentation of endogenous peptide antigen via MHC class Ib] GO:0002477[antigen processing and presentation of exogenous peptide antigen via MHC class Ib] GO:0002725[negative regulation of T cell cytokine production] GO:0002728[negative regulation of natural killer cell cytokine production] GO:0002729[positive regulation of natural killer cell cytokine production] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005886[plasma membrane] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0030670[phagocytic vesicle membrane] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0032398[MHC class Ib protein complex] GO:0042605[peptide antigen binding] GO:0042612[MHC class I protein complex] GO:0043322[negative regulation of natural killer cell degranulation] GO:0043323[positive regulation of natural killer cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0055038[recycling endosome membrane] GO:0071889[14-3-3 protein binding] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1901215[negative regulation of neuron death]
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F
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Q5JZ47 [Target identity:100%; Query identity:100%] MHC class I antigen; Major histocompatibility complex, class I, F
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000139[Golgi membrane] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002476[antigen processing and presentation of endogenous peptide antigen via MHC class Ib] GO:0002477[antigen processing and presentation of exogenous peptide antigen via MHC class Ib] GO:0002725[negative regulation of T cell cytokine production] GO:0002728[negative regulation of natural killer cell cytokine production] GO:0002729[positive regulation of natural killer cell cytokine production] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005886[plasma membrane] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0030670[phagocytic vesicle membrane] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0032398[MHC class Ib protein complex] GO:0042605[peptide antigen binding] GO:0042612[MHC class I protein complex] GO:0043322[negative regulation of natural killer cell degranulation] GO:0043323[positive regulation of natural killer cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0055038[recycling endosome membrane] GO:0071889[14-3-3 protein binding] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1901215[negative regulation of neuron death]
P30511 [Direct mapping] HLA class I histocompatibility antigen, alpha chain F
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000139[Golgi membrane] GO:0001916[positive regulation of T cell mediated cytotoxicity] GO:0002376[immune system process] GO:0002474[antigen processing and presentation of peptide antigen via MHC class I] GO:0002476[antigen processing and presentation of endogenous peptide antigen via MHC class Ib] GO:0002477[antigen processing and presentation of exogenous peptide antigen via MHC class Ib] GO:0002725[negative regulation of T cell cytokine production] GO:0002728[negative regulation of natural killer cell cytokine production] GO:0002729[positive regulation of natural killer cell cytokine production] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005764[lysosome] GO:0005765[lysosomal membrane] GO:0005768[endosome] GO:0005783[endoplasmic reticulum] GO:0005886[plasma membrane] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0012507[ER to Golgi transport vesicle membrane] GO:0016020[membrane] GO:0030670[phagocytic vesicle membrane] GO:0030881[beta-2-microglobulin binding] GO:0031901[early endosome membrane] GO:0032398[MHC class Ib protein complex] GO:0042605[peptide antigen binding] GO:0042612[MHC class I protein complex] GO:0043322[negative regulation of natural killer cell degranulation] GO:0043323[positive regulation of natural killer cell degranulation] GO:0045953[negative regulation of natural killer cell mediated cytotoxicity] GO:0046978[TAP1 binding] GO:0046979[TAP2 binding] GO:0055038[recycling endosome membrane] GO:0071889[14-3-3 protein binding] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:1901215[negative regulation of neuron death]
The Human Protein Atlas project is funded
