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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p22.1
Chromosome location (bp)
30136124 - 30148735
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response 1,2. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation 3. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0008270[zinc ion binding] GO:0008385[IkappaB kinase complex] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0042177[negative regulation of protein catabolic process] GO:0045087[innate immune response] GO:0045116[protein neddylation] GO:0046872[metal ion binding] GO:0061630[ubiquitin protein ligase activity] GO:1900181[negative regulation of protein localization to nucleus] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0008270[zinc ion binding] GO:0008385[IkappaB kinase complex] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0042177[negative regulation of protein catabolic process] GO:0045087[innate immune response] GO:0045116[protein neddylation] GO:0046872[metal ion binding] GO:0061630[ubiquitin protein ligase activity] GO:1900181[negative regulation of protein localization to nucleus] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0008270[zinc ion binding] GO:0008385[IkappaB kinase complex] GO:0010468[regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0030308[negative regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0042177[negative regulation of protein catabolic process] GO:0045087[innate immune response] GO:0045116[protein neddylation] GO:0046872[metal ion binding] GO:0061630[ubiquitin protein ligase activity] GO:1900181[negative regulation of protein localization to nucleus] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
The Human Protein Atlas project is funded
