Expression of NPY4R in urothelial cancer - The Human Protein Atlas

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SUMMARY

TISSUE

BRAIN

SINGLE CELL

SUBCELL

CANCER

BLOOD

CELL LINE

STRUCTURE

INTERACTION

NPY4R

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

NPY4R is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : N/A

Median expressionⁱ : 0.02

Median follow up timeⁱ : 1.13

P scoreⁱ 0.026

5-year survival highⁱ 2%

5-year survival lowⁱ 6%

TCGA RNA samplesⁱ

Average pTPM

0.2

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	10.7
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	5.2
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	2.0
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	1.1
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	1.1
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	0.9
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	0.9
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	0.8
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	0.7
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	0.6
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	0.6
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	0.6
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	0.6
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	0.5
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	0.5
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	0.5
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	0.5
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	0.5
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	0.4
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	0.4
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	0.4
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	0.4
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	0.4
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	0.4
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	0.4
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	0.4
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	0.4
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	0.4
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	0.4
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	0.3
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	0.3
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	0.3
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	0.3
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	0.3
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	0.3
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	0.3
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	0.3
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	0.2
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	0.2
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	0.2
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	0.2
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	0.2
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	0.2
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	0.2
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	0.2
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	0.2
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	0.2
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	0.2
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	0.2
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	0.2
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	0.2
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	0.2
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	0.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	0.2
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	0.2
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	0.2
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	0.1
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	0.1
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	0.1
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	0.1
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	0.1
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	0.1
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	0.1
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	0.1
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	0.1
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	0.1
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	0.1
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	0.1
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	0.1
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	0.1
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	0.1
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	0.1
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	0.1
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	0.1
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	0.1
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	0.1
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	0.1
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	0.1
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	0.0
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	0.0
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	0.0
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	0.0
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	0.0
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	0.0
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	0.0
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	0.0
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	0.0
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	0.0
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	0.0
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	0.0
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	0.0
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	0.0
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	0.0
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	0.0
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	0.0
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	0.0
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	0.0
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	0.0
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	0.0
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	0.0
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	0.0
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	0.0
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	0.0
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	0.0
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	0.0
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	0.0
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	0.0
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	0.0
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	0.0
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	0.0
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	0.0
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	0.0
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	0.0
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	0.0
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	0.0
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	0.0
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	0.0
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	0.0
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	0.0
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	0.0
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	0.0
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	0.0
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	0.0
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	0.0
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	0.0
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	0.0
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	0.0
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	0.0
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	0.0
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	0.0
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	0.0
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	0.0
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	0.0
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	0.0
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	0.0
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	0.0
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	0.0
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	0.0
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	0.0
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	0.0
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	0.0
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	0.0
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	0.0
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	0.0
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	0.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	0.0
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	0.0
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	0.0
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	0.0
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	0.0
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	0.0
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	0.0
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	0.0
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	0.0
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	0.0
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	0.0
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	0.0
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	0.0
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	0.0
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	0.0
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	0.0
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	0.0
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	0.0
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	0.0
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	0.0
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	0.0
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	0.0
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	0.0
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	0.0
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample. Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes. Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based) Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts	Antibody HPA027863
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade

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The Human Protein Atlas

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