We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q24
Chromosome location (bp)
146515180 - 146544856
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface 1,2,3,4,5,6,7,8,9,10,11,12. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A 13,14. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages 15. May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes 16. Inhibits the functions of viral transactivators, including human T-cell leukemia virus (HTLV)-1 protein Tax, human immunodeficiency virus (HIV)-1 Tat, human hepatitis B virus (HBV) HBx, Epstein-Barr virus (EBV) BZLF1 and human cytomegalovirus IE1 and IE2 proteins through direct interactions 17,18,19,20,21. Mediates also the inhibition of influenza virus infection by preventing nuclear import of the viral nucleoprotein/NP 22,23. Plays a crucial role as a defense factor against SARS-CoV-2 independently of its scramblase activity by directly targeting nascent viral vesicles to prevent virus-membrane fusion and the release of viral RNA into the host-cell cytosol 24....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Host cell receptor for virus entry, Hydrolase, Nuclease, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Antiviral defense, Host-virus interaction, Lipid transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Magnesium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001618[virus receptor activity] GO:0003677[DNA binding] GO:0004518[nuclease activity] GO:0005154[epidermal growth factor receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006659[phosphatidylserine biosynthetic process] GO:0006869[lipid transport] GO:0006915[apoptotic process] GO:0006953[acute-phase response] GO:0008270[zinc ion binding] GO:0010288[response to lead ion] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0017121[plasma membrane phospholipid scrambling] GO:0017124[SH3 domain binding] GO:0017128[phospholipid scramblase activity] GO:0019899[enzyme binding] GO:0030168[platelet activation] GO:0032791[lead ion binding] GO:0033003[regulation of mast cell activation] GO:0035456[response to interferon-beta] GO:0042609[CD4 receptor binding] GO:0045071[negative regulation of viral genome replication] GO:0045089[positive regulation of innate immune response] GO:0045121[membrane raft] GO:0045340[mercury ion binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046718[viral entry into host cell] GO:0048471[perinuclear region of cytoplasm] GO:0050765[negative regulation of phagocytosis] GO:0051607[defense response to virus] GO:0060368[regulation of Fc receptor mediated stimulatory signaling pathway] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070782[phosphatidylserine exposure on apoptotic cell surface] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:1905820[positive regulation of chromosome separation] GO:2000373[positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001618[virus receptor activity] GO:0003677[DNA binding] GO:0004518[nuclease activity] GO:0005154[epidermal growth factor receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006659[phosphatidylserine biosynthetic process] GO:0006869[lipid transport] GO:0006915[apoptotic process] GO:0006953[acute-phase response] GO:0008270[zinc ion binding] GO:0010288[response to lead ion] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0017121[plasma membrane phospholipid scrambling] GO:0017124[SH3 domain binding] GO:0017128[phospholipid scramblase activity] GO:0019899[enzyme binding] GO:0030168[platelet activation] GO:0032791[lead ion binding] GO:0033003[regulation of mast cell activation] GO:0035456[response to interferon-beta] GO:0042609[CD4 receptor binding] GO:0045071[negative regulation of viral genome replication] GO:0045089[positive regulation of innate immune response] GO:0045121[membrane raft] GO:0045340[mercury ion binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046718[viral entry into host cell] GO:0048471[perinuclear region of cytoplasm] GO:0050765[negative regulation of phagocytosis] GO:0051607[defense response to virus] GO:0060368[regulation of Fc receptor mediated stimulatory signaling pathway] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070782[phosphatidylserine exposure on apoptotic cell surface] GO:0090305[nucleic acid phosphodiester bond hydrolysis] GO:1905820[positive regulation of chromosome separation] GO:2000373[positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
