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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q33.2
Chromosome location (bp)
105465867 - 105491034
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May suppress DAO (D-amino acid oxidase) and SOD1 activity and promote their degradation 1,2,3,4. Has conversely also been suggested to function as a DAO activator 5,6,7. May stimulate the degradation of DDO (D-aspartate oxidase) 8. May play a role in mitochondrial fission 9....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005739[mitochondrion] GO:0005794[Golgi apparatus] GO:0008047[enzyme activator activity] GO:0019899[enzyme binding] GO:0043085[positive regulation of catalytic activity] GO:0048471[perinuclear region of cytoplasm] GO:1900758[negative regulation of D-amino-acid oxidase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005739[mitochondrion] GO:0005794[Golgi apparatus] GO:0008047[enzyme activator activity] GO:0019899[enzyme binding] GO:0043085[positive regulation of catalytic activity] GO:0048471[perinuclear region of cytoplasm] GO:1900758[negative regulation of D-amino-acid oxidase activity]
A2T115 [Direct mapping] D-amino acid oxidase activator; Schizophrenia-and bipolar disorder-associated protein G72 isoform C; Schizophrenia-and bipolar disorder-associated protein G72 isoform D
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other diseases Mental and behavioural disorders
Show all
GO:1900758[negative regulation of D-amino-acid oxidase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005739[mitochondrion] GO:0005794[Golgi apparatus] GO:0008047[enzyme activator activity] GO:0019899[enzyme binding] GO:0043085[positive regulation of catalytic activity] GO:0048471[perinuclear region of cytoplasm] GO:1900758[negative regulation of D-amino-acid oxidase activity]
The Human Protein Atlas project is funded
