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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.3
Chromosome location (bp)
56202179 - 56221933
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Autophagy, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005128[erythropoietin receptor binding] GO:0005135[interleukin-3 receptor binding] GO:0005515[protein binding] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0010498[proteasomal protein catabolic process] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0030971[receptor tyrosine kinase binding] GO:0031267[small GTPase binding] GO:0042802[identical protein binding] GO:0043408[regulation of MAPK cascade] GO:0045619[regulation of lymphocyte differentiation] GO:0045637[regulation of myeloid cell differentiation] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051865[protein autoubiquitination] GO:0051896[regulation of protein kinase B signaling] GO:0061630[ubiquitin protein ligase activity] GO:0071782[endoplasmic reticulum tubular network] GO:0097191[extrinsic apoptotic signaling pathway] GO:1901525[negative regulation of mitophagy] GO:2000377[regulation of reactive oxygen species metabolic process] GO:2000379[positive regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0010498[proteasomal protein catabolic process] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0030971[receptor tyrosine kinase binding] GO:0031267[small GTPase binding] GO:0042802[identical protein binding] GO:0043408[regulation of MAPK cascade] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051865[protein autoubiquitination] GO:0051896[regulation of protein kinase B signaling] GO:0061630[ubiquitin protein ligase activity] GO:0071782[endoplasmic reticulum tubular network] GO:0097191[extrinsic apoptotic signaling pathway] GO:2000377[regulation of reactive oxygen species metabolic process] GO:2000379[positive regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0010498[proteasomal protein catabolic process] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0030971[receptor tyrosine kinase binding] GO:0031267[small GTPase binding] GO:0042802[identical protein binding] GO:0043408[regulation of MAPK cascade] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051865[protein autoubiquitination] GO:0051896[regulation of protein kinase B signaling] GO:0061630[ubiquitin protein ligase activity] GO:0071782[endoplasmic reticulum tubular network] GO:0097191[extrinsic apoptotic signaling pathway] GO:2000377[regulation of reactive oxygen species metabolic process] GO:2000379[positive regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005829[cytosol] GO:0006914[autophagy] GO:0006915[apoptotic process] GO:0008270[zinc ion binding] GO:0008285[negative regulation of cell population proliferation] GO:0010498[proteasomal protein catabolic process] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0030971[receptor tyrosine kinase binding] GO:0031267[small GTPase binding] GO:0042802[identical protein binding] GO:0043408[regulation of MAPK cascade] GO:0045732[positive regulation of protein catabolic process] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051865[protein autoubiquitination] GO:0051896[regulation of protein kinase B signaling] GO:0061630[ubiquitin protein ligase activity] GO:0071782[endoplasmic reticulum tubular network] GO:0097191[extrinsic apoptotic signaling pathway] GO:2000377[regulation of reactive oxygen species metabolic process] GO:2000379[positive regulation of reactive oxygen species metabolic process]
The Human Protein Atlas project is funded
