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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q13.33
Chromosome location (bp)
121631399 - 121660927
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P14317 [Direct mapping] Hematopoietic lineage cell-specific protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0008284[positive regulation of cell population proliferation] GO:0009725[response to hormone] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0019901[protein kinase binding] GO:0030041[actin filament polymerization] GO:0030218[erythrocyte differentiation] GO:0030427[site of polarized growth] GO:0030833[regulation of actin filament polymerization] GO:0030854[positive regulation of granulocyte differentiation] GO:0030864[cortical actin cytoskeleton] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035556[intracellular signal transduction] GO:0042307[positive regulation of protein import into nucleus] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0044877[protein-containing complex binding] GO:0045651[positive regulation of macrophage differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051015[actin filament binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051897[positive regulation of protein kinase B signaling] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071345[cellular response to cytokine stimulus] GO:0110165[cellular anatomical entity] GO:2000107[negative regulation of leukocyte apoptotic process] GO:2000251[positive regulation of actin cytoskeleton reorganization]
The Human Protein Atlas project is funded
