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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.31
Chromosome location (bp)
49683947 - 49689501
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
H7C0F8 [Direct mapping] Hepatocyte growth factor-like protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Other immune system diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004252[serine-type endopeptidase activity] GO:0005737[cytoplasm] GO:0005773[vacuole] GO:0006508[proteolysis] GO:0007283[spermatogenesis] GO:0007566[embryo implantation] GO:0010628[positive regulation of gene expression] GO:0010758[regulation of macrophage chemotaxis] GO:0016570[histone modification] GO:0019899[enzyme binding] GO:0030317[flagellated sperm motility] GO:0030879[mammary gland development] GO:0030971[receptor tyrosine kinase binding] GO:0033601[positive regulation of mammary gland epithelial cell proliferation] GO:0035173[histone kinase activity] GO:0043065[positive regulation of apoptotic process] GO:0046425[regulation of receptor signaling pathway via JAK-STAT] GO:0060763[mammary duct terminal end bud growth] GO:0071346[cellular response to interferon-gamma] GO:0071456[cellular response to hypoxia] GO:1904036[negative regulation of epithelial cell apoptotic process]
The Human Protein Atlas project is funded
