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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p11.2
Chromosome location (bp)
19377721 - 19383544
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13164 [Direct mapping] Mitogen-activated protein kinase 7
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004707[MAP kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019933[cAMP-mediated signaling] GO:0030154[cell differentiation] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0035556[intracellular signal transduction] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050728[negative regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0051247[positive regulation of protein metabolic process] GO:0051344[negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0060761[negative regulation of response to cytokine stimulus] GO:0070301[cellular response to hydrogen peroxide] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0106310[protein serine kinase activity] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7
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A0A024QZ20 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004707[MAP kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019933[cAMP-mediated signaling] GO:0030154[cell differentiation] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0035556[intracellular signal transduction] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050728[negative regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0051247[positive regulation of protein metabolic process] GO:0051344[negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0060761[negative regulation of response to cytokine stimulus] GO:0070301[cellular response to hydrogen peroxide] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0106310[protein serine kinase activity] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7
Show all
A0A024QZ20 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004707[MAP kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019933[cAMP-mediated signaling] GO:0030154[cell differentiation] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0035556[intracellular signal transduction] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043231[intracellular membrane-bounded organelle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050728[negative regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0051247[positive regulation of protein metabolic process] GO:0051344[negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0060761[negative regulation of response to cytokine stimulus] GO:0070301[cellular response to hydrogen peroxide] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0106310[protein serine kinase activity] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7
Show all
A0A024QZ20 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004707[MAP kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006468[protein phosphorylation] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0019933[cAMP-mediated signaling] GO:0030154[cell differentiation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0035556[intracellular signal transduction] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045765[regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050728[negative regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0051247[positive regulation of protein metabolic process] GO:0051344[negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0060761[negative regulation of response to cytokine stimulus] GO:0070301[cellular response to hydrogen peroxide] GO:0070885[negative regulation of calcineurin-NFAT signaling cascade] GO:0071363[cellular response to growth factor stimulus] GO:0071499[cellular response to laminar fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0106310[protein serine kinase activity] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
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