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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
TAL bHLH transcription factor 1, erythroid differentiation factor
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p33
Chromosome location (bp)
47216290 - 47232225
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P17542 [Direct mapping] T-cell acute lymphocytic leukemia protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0019899[enzyme binding] GO:0030097[hemopoiesis] GO:0030154[cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030219[megakaryocyte differentiation] GO:0030221[basophil differentiation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0035162[embryonic hemopoiesis] GO:0042826[histone deacetylase binding] GO:0045165[cell fate commitment] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0051781[positive regulation of cell division] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070888[E-box binding] GO:1905269[positive regulation of chromatin organization]
P17542 [Direct mapping] T-cell acute lymphocytic leukemia protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0019899[enzyme binding] GO:0030097[hemopoiesis] GO:0030154[cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030219[megakaryocyte differentiation] GO:0030221[basophil differentiation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0035162[embryonic hemopoiesis] GO:0042826[histone deacetylase binding] GO:0045165[cell fate commitment] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0051781[positive regulation of cell division] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070888[E-box binding] GO:1905269[positive regulation of chromatin organization]
P17542 [Direct mapping] T-cell acute lymphocytic leukemia protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001525[angiogenesis] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007626[locomotory behavior] GO:0019899[enzyme binding] GO:0021527[spinal cord association neuron differentiation] GO:0021953[central nervous system neuron differentiation] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030219[megakaryocyte differentiation] GO:0030220[platelet formation] GO:0030221[basophil differentiation] GO:0030297[transmembrane receptor protein tyrosine kinase activator activity] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032991[protein-containing complex] GO:0035162[embryonic hemopoiesis] GO:0035855[megakaryocyte development] GO:0042127[regulation of cell population proliferation] GO:0042826[histone deacetylase binding] GO:0043249[erythrocyte maturation] GO:0045165[cell fate commitment] GO:0045637[regulation of myeloid cell differentiation] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045931[positive regulation of mitotic cell cycle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048699[generation of neurons] GO:0051781[positive regulation of cell division] GO:0060018[astrocyte fate commitment] GO:0060216[definitive hemopoiesis] GO:0060217[hemangioblast cell differentiation] GO:0060218[hematopoietic stem cell differentiation] GO:0060375[regulation of mast cell differentiation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070888[E-box binding] GO:1904672[regulation of somatic stem cell population maintenance] GO:1905269[positive regulation of chromatin organization]
The Human Protein Atlas project is funded
