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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q21.22
Chromosome location (bp)
83090048 - 83137075
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9NZF1 [Direct mapping] Placenta-specific gene 8 protein
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X2BQ60 [Target identity:100%; Query identity:100%] Down-regulated in gastrointestinal cancer protein; Placenta-specific 8, isoform CRA_a
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003682[chromatin binding] GO:0005576[extracellular region] GO:0006366[transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009409[response to cold] GO:0035578[azurophil granule lumen] GO:0040015[negative regulation of multicellular organism growth] GO:0042742[defense response to bacterium] GO:0043066[negative regulation of apoptotic process] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050873[brown fat cell differentiation] GO:0120162[positive regulation of cold-induced thermogenesis]
Q9NZF1 [Direct mapping] Placenta-specific gene 8 protein
Show all
X2BQ60 [Target identity:100%; Query identity:100%] Down-regulated in gastrointestinal cancer protein; Placenta-specific 8, isoform CRA_a
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576[extracellular region] GO:0035578[azurophil granule lumen] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0120162[positive regulation of cold-induced thermogenesis]
Q9NZF1 [Direct mapping] Placenta-specific gene 8 protein
Show all
X2BQ60 [Target identity:100%; Query identity:100%] Down-regulated in gastrointestinal cancer protein; Placenta-specific 8, isoform CRA_a
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576[extracellular region] GO:0035578[azurophil granule lumen] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0120162[positive regulation of cold-induced thermogenesis]
Q9NZF1 [Direct mapping] Placenta-specific gene 8 protein
Show all
X2BQ60 [Target identity:100%; Query identity:100%] Down-regulated in gastrointestinal cancer protein; Placenta-specific 8, isoform CRA_a
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576[extracellular region] GO:0035578[azurophil granule lumen] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0120162[positive regulation of cold-induced thermogenesis]
The Human Protein Atlas project is funded
