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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p12
Chromosome location (bp)
79025686 - 79028505
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antimicrobial
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Acute phase, Inflammatory response
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lectin, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6UW15 [Direct mapping] Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0008284[positive regulation of cell population proliferation] GO:0010838[positive regulation of keratinocyte proliferation] GO:0030246[carbohydrate binding] GO:0038023[signaling receptor activity] GO:0042834[peptidoglycan binding] GO:0043434[response to peptide hormone] GO:0044278[cell wall disruption in another organism] GO:0045617[negative regulation of keratinocyte differentiation] GO:0050830[defense response to Gram-positive bacterium] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070492[oligosaccharide binding] GO:0090303[positive regulation of wound healing]
Q6UW15 [Direct mapping] Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0008284[positive regulation of cell population proliferation] GO:0010838[positive regulation of keratinocyte proliferation] GO:0030246[carbohydrate binding] GO:0038023[signaling receptor activity] GO:0042834[peptidoglycan binding] GO:0043434[response to peptide hormone] GO:0044278[cell wall disruption in another organism] GO:0045617[negative regulation of keratinocyte differentiation] GO:0050830[defense response to Gram-positive bacterium] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070492[oligosaccharide binding] GO:0090303[positive regulation of wound healing]
Q6UW15 [Direct mapping] Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0008284[positive regulation of cell population proliferation] GO:0010838[positive regulation of keratinocyte proliferation] GO:0030246[carbohydrate binding] GO:0038023[signaling receptor activity] GO:0042834[peptidoglycan binding] GO:0043434[response to peptide hormone] GO:0044278[cell wall disruption in another organism] GO:0045617[negative regulation of keratinocyte differentiation] GO:0050830[defense response to Gram-positive bacterium] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0070492[oligosaccharide binding] GO:0090303[positive regulation of wound healing]
The Human Protein Atlas project is funded
