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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.3
Chromosome location (bp)
1494577 - 1516742
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate 1,2. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate 3. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9BT40 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001726[ruffle] GO:0001933[negative regulation of protein phosphorylation] GO:0003824[catalytic activity] GO:0004439[phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity] GO:0004445[inositol-polyphosphate 5-phosphatase activity] GO:0005000[vasopressin receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005979[regulation of glycogen biosynthetic process] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0007186[G protein-coupled receptor signaling pathway] GO:0010801[negative regulation of peptidyl-threonine phosphorylation] GO:0010829[negative regulation of glucose transmembrane transport] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016312[inositol bisphosphate phosphatase activity] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019637[organophosphate metabolic process] GO:0030036[actin cytoskeleton organization] GO:0032587[ruffle membrane] GO:0032869[cellular response to insulin stimulus] GO:0032870[cellular response to hormone stimulus] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034485[phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] GO:0034594[phosphatidylinositol trisphosphate phosphatase activity] GO:0034595[phosphatidylinositol phosphate 5-phosphatase activity] GO:0035305[negative regulation of dephosphorylation] GO:0035810[positive regulation of urine volume] GO:0042577[lipid phosphatase activity] GO:0042593[glucose homeostasis] GO:0043005[neuron projection] GO:0043407[negative regulation of MAP kinase activity] GO:0043922[negative regulation by host of viral transcription] GO:0045719[negative regulation of glycogen biosynthetic process] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046030[inositol trisphosphate phosphatase activity] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046855[inositol phosphate dephosphorylation] GO:0046856[phosphatidylinositol dephosphorylation] GO:0048471[perinuclear region of cytoplasm] GO:0051497[negative regulation of stress fiber assembly] GO:0051898[negative regulation of protein kinase B signaling] GO:0051926[negative regulation of calcium ion transport] GO:0052658[inositol-1,4,5-trisphosphate 5-phosphatase activity] GO:0052659[inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity] GO:0071320[cellular response to cAMP] GO:0071356[cellular response to tumor necrosis factor] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0072659[protein localization to plasma membrane] GO:0090315[negative regulation of protein targeting to membrane] GO:0097178[ruffle assembly] GO:0110165[cellular anatomical entity] GO:2000466[negative regulation of glycogen (starch) synthase activity] GO:2001153[positive regulation of renal water transport]
Q9BT40 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001726[ruffle] GO:0001933[negative regulation of protein phosphorylation] GO:0003824[catalytic activity] GO:0004439[phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity] GO:0004445[inositol-polyphosphate 5-phosphatase activity] GO:0005000[vasopressin receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005979[regulation of glycogen biosynthetic process] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0007186[G protein-coupled receptor signaling pathway] GO:0010801[negative regulation of peptidyl-threonine phosphorylation] GO:0010829[negative regulation of glucose transmembrane transport] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016312[inositol bisphosphate phosphatase activity] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019637[organophosphate metabolic process] GO:0030036[actin cytoskeleton organization] GO:0032587[ruffle membrane] GO:0032869[cellular response to insulin stimulus] GO:0032870[cellular response to hormone stimulus] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034485[phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] GO:0034594[phosphatidylinositol trisphosphate phosphatase activity] GO:0034595[phosphatidylinositol phosphate 5-phosphatase activity] GO:0035305[negative regulation of dephosphorylation] GO:0035810[positive regulation of urine volume] GO:0042577[lipid phosphatase activity] GO:0042593[glucose homeostasis] GO:0043005[neuron projection] GO:0043407[negative regulation of MAP kinase activity] GO:0043922[negative regulation by host of viral transcription] GO:0045719[negative regulation of glycogen biosynthetic process] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046030[inositol trisphosphate phosphatase activity] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046855[inositol phosphate dephosphorylation] GO:0046856[phosphatidylinositol dephosphorylation] GO:0048471[perinuclear region of cytoplasm] GO:0051497[negative regulation of stress fiber assembly] GO:0051898[negative regulation of protein kinase B signaling] GO:0051926[negative regulation of calcium ion transport] GO:0052658[inositol-1,4,5-trisphosphate 5-phosphatase activity] GO:0052659[inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity] GO:0071320[cellular response to cAMP] GO:0071356[cellular response to tumor necrosis factor] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0072659[protein localization to plasma membrane] GO:0090315[negative regulation of protein targeting to membrane] GO:0097178[ruffle assembly] GO:0110165[cellular anatomical entity] GO:2000466[negative regulation of glycogen (starch) synthase activity] GO:2001153[positive regulation of renal water transport]
Q9BT40 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Enzymes ENZYME proteins Hydrolases Metabolic proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001701[in utero embryonic development] GO:0001726[ruffle] GO:0001933[negative regulation of protein phosphorylation] GO:0003824[catalytic activity] GO:0004439[phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity] GO:0004445[inositol-polyphosphate 5-phosphatase activity] GO:0005000[vasopressin receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005802[trans-Golgi network] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005979[regulation of glycogen biosynthetic process] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0007186[G protein-coupled receptor signaling pathway] GO:0010801[negative regulation of peptidyl-threonine phosphorylation] GO:0010829[negative regulation of glucose transmembrane transport] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016312[inositol bisphosphate phosphatase activity] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019637[organophosphate metabolic process] GO:0030036[actin cytoskeleton organization] GO:0032587[ruffle membrane] GO:0032868[response to insulin] GO:0032869[cellular response to insulin stimulus] GO:0032870[cellular response to hormone stimulus] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034485[phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] GO:0034594[phosphatidylinositol trisphosphate phosphatase activity] GO:0034595[phosphatidylinositol phosphate 5-phosphatase activity] GO:0035305[negative regulation of dephosphorylation] GO:0035810[positive regulation of urine volume] GO:0042577[lipid phosphatase activity] GO:0042593[glucose homeostasis] GO:0043005[neuron projection] GO:0043407[negative regulation of MAP kinase activity] GO:0043922[negative regulation by host of viral transcription] GO:0045719[negative regulation of glycogen biosynthetic process] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046030[inositol trisphosphate phosphatase activity] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046855[inositol phosphate dephosphorylation] GO:0046856[phosphatidylinositol dephosphorylation] GO:0048471[perinuclear region of cytoplasm] GO:0051497[negative regulation of stress fiber assembly] GO:0051898[negative regulation of protein kinase B signaling] GO:0051926[negative regulation of calcium ion transport] GO:0052658[inositol-1,4,5-trisphosphate 5-phosphatase activity] GO:0052659[inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity] GO:0071320[cellular response to cAMP] GO:0071356[cellular response to tumor necrosis factor] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0072659[protein localization to plasma membrane] GO:0090315[negative regulation of protein targeting to membrane] GO:0097178[ruffle assembly] GO:0110165[cellular anatomical entity] GO:2000466[negative regulation of glycogen (starch) synthase activity] GO:2001153[positive regulation of renal water transport]
C9JZB0 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
K7EPG6 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Metabolic proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
K7ENF7 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Metabolic proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
I3L0Y0 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Metabolic proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
I3L4A5 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
I3L2L1 [Direct mapping] Inositol polyphosphate 5-phosphatase K
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Metabolic proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)