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The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
Annotated protein expressioni
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
HPA006458
Most normal tissues displayed strong nuclear staining in a small fraction of the cells, in some cases accompanied with faint cytoplasmic immunoreactivity. In squamous epithelia, basal layers of stratum spinosum showed positivity. Lymphoid tissues displayed strong immunoreactivity in all reaction center cells, while only a small fraction of the cells outside reaction centra were positive. In placenta, cytotrophoblasts stained strongly, whereas syncytiotrophoblasts generally were negative. Muscle tissues and cells of liver, pancreas and the central nervous system were faintly stained or negative.
HPA026773
Subsets of normal cells in the gastrointestinal tract, squamous epithelia, fallopian tube and placenta displayed moderate nuclear staining. Strong nuclear positivity was observed in subsets of cells in testis, bone marrow and lymphoid tissue. Remaining normal cells were weakly stained or negative.
Most normal and malignant tissues showed distinct nuclear positivity in a fraction of cells.
Liver, kidney, cells in CNS, muscle tissue were negative.
CAB002448
Most normal cells showed moderate to strong nuclear positivity. Liver, pancreas, ovary, cns and myocytes were negative.