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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
p11.3
Chromosome location (bp)
47078355 - 47093314
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)- dependent cellular processes and enzyme activities (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822[kidney development] GO:0001889[liver development] GO:0001933[negative regulation of protein phosphorylation] GO:0004341[gluconolactonase activity] GO:0005509[calcium ion binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006469[negative regulation of protein kinase activity] GO:0006874[cellular calcium ion homeostasis] GO:0007283[spermatogenesis] GO:0007568[aging] GO:0008270[zinc ion binding] GO:0010867[positive regulation of triglyceride biosynthetic process] GO:0010907[positive regulation of glucose metabolic process] GO:0010922[positive regulation of phosphatase activity] GO:0016787[hydrolase activity] GO:0019853[L-ascorbic acid biosynthetic process] GO:0030234[enzyme regulator activity] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0032781[positive regulation of ATP-dependent activity] GO:0034260[negative regulation of GTPase activity] GO:0043066[negative regulation of apoptotic process] GO:0043547[positive regulation of GTPase activity] GO:0045019[negative regulation of nitric oxide biosynthetic process] GO:0045723[positive regulation of fatty acid biosynthetic process] GO:0046872[metal ion binding] GO:0050680[negative regulation of epithelial cell proliferation] GO:0050848[regulation of calcium-mediated signaling] GO:0051344[negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0097421[liver regeneration] GO:1901318[negative regulation of flagellated sperm motility] GO:1901671[positive regulation of superoxide dismutase activity] GO:1901896[positive regulation of ATPase-coupled calcium transmembrane transporter activity] GO:1902679[negative regulation of RNA biosynthetic process] GO:1903011[negative regulation of bone development] GO:1903052[positive regulation of proteolysis involved in protein catabolic process] GO:1903611[negative regulation of calcium-dependent ATPase activity] GO:1903625[negative regulation of DNA catabolic process] GO:1903629[positive regulation of dUTP diphosphatase activity] GO:1903634[negative regulation of leucine-tRNA ligase activity] GO:2000279[negative regulation of DNA biosynthetic process]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
