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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Apolipoprotein B mRNA editing enzyme catalytic subunit 3F
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q13.1
Chromosome location (bp)
39040604 - 39055972
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms 1,2,3,4. Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 5,6,7,8,9,10,11,12,13. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA 14. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells 15. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA 16. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons 17,18,19,20,21. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation 22....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8IUX4 [Direct mapping] DNA dC->dU-editing enzyme APOBEC-3F
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000932[P-body] GO:0002230[positive regulation of defense response to virus by host] GO:0002376[immune system process] GO:0003723[RNA binding] GO:0003824[catalytic activity] GO:0004126[cytidine deaminase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0008270[zinc ion binding] GO:0009972[cytidine deamination] GO:0010529[negative regulation of transposition] GO:0016553[base conversion or substitution editing] GO:0016554[cytidine to uridine editing] GO:0016787[hydrolase activity] GO:0030895[apolipoprotein B mRNA editing enzyme complex] GO:0042802[identical protein binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0046872[metal ion binding] GO:0047844[deoxycytidine deaminase activity] GO:0048525[negative regulation of viral process] GO:0051607[defense response to virus] GO:0070383[DNA cytosine deamination] GO:0080111[DNA demethylation] GO:1990904[ribonucleoprotein complex]
Q8IUX4 [Direct mapping] DNA dC->dU-editing enzyme APOBEC-3F
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932[P-body] GO:0002230[positive regulation of defense response to virus by host] GO:0002376[immune system process] GO:0003723[RNA binding] GO:0003824[catalytic activity] GO:0004126[cytidine deaminase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0008270[zinc ion binding] GO:0009972[cytidine deamination] GO:0010529[negative regulation of transposition] GO:0016553[base conversion or substitution editing] GO:0016554[cytidine to uridine editing] GO:0016787[hydrolase activity] GO:0030895[apolipoprotein B mRNA editing enzyme complex] GO:0042802[identical protein binding] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045869[negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0046872[metal ion binding] GO:0047844[deoxycytidine deaminase activity] GO:0048525[negative regulation of viral process] GO:0051607[defense response to virus] GO:0070383[DNA cytosine deamination] GO:0080111[DNA demethylation] GO:1990904[ribonucleoprotein complex]
The Human Protein Atlas project is funded
