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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.31
Chromosome location (bp)
100912963 - 100965134
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance 1. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks 2. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions 3. Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication 4....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA repair
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in chromatin; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8IX21 [Direct mapping] SMC5-SMC6 complex localization factor protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000724[double-strand break repair via homologous recombination] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016925[protein sumoylation] GO:0030915[Smc5-Smc6 complex] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031625[ubiquitin protein ligase binding] GO:0032204[regulation of telomere maintenance] GO:0034184[positive regulation of maintenance of mitotic sister chromatid cohesion] GO:0035861[site of double-strand break] GO:0043231[intracellular membrane-bounded organelle] GO:0044877[protein-containing complex binding] GO:1990166[protein localization to site of double-strand break] GO:2000781[positive regulation of double-strand break repair]
Q8IX21 [Direct mapping] SMC5-SMC6 complex localization factor protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0016925[protein sumoylation] GO:0030915[Smc5-Smc6 complex] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031625[ubiquitin protein ligase binding] GO:0032204[regulation of telomere maintenance] GO:0034184[positive regulation of maintenance of mitotic sister chromatid cohesion] GO:0035861[site of double-strand break] GO:0043231[intracellular membrane-bounded organelle] GO:0044877[protein-containing complex binding] GO:1990166[protein localization to site of double-strand break] GO:2000781[positive regulation of double-strand break repair]
The Human Protein Atlas project is funded
