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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q25.1
Chromosome location (bp)
173183731 - 173207331
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P23510 [Direct mapping] Tumor necrosis factor ligand superfamily member 4
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CD markers Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cardiovascular diseases Cardiac diseases Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001819[positive regulation of cytokine production] GO:0002215[defense response to nematode] GO:0002526[acute inflammatory response] GO:0002639[positive regulation of immunoglobulin production] GO:0002726[positive regulation of T cell cytokine production] GO:0002819[regulation of adaptive immune response] GO:0002830[positive regulation of type 2 immune response] GO:0002891[positive regulation of immunoglobulin mediated immune response] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007154[cell communication] GO:0007165[signal transduction] GO:0008284[positive regulation of cell population proliferation] GO:0009615[response to virus] GO:0009986[cell surface] GO:0016020[membrane] GO:0023052[signaling] GO:0032689[negative regulation of interferon-gamma production] GO:0032700[negative regulation of interleukin-17 production] GO:0032722[positive regulation of chemokine production] GO:0032729[positive regulation of interferon-gamma production] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032813[tumor necrosis factor receptor superfamily binding] GO:0035709[memory T cell activation] GO:0035712[T-helper 2 cell activation] GO:0035713[response to nitrogen dioxide] GO:0042102[positive regulation of T cell proliferation] GO:0043372[positive regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043382[positive regulation of memory T cell differentiation] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045590[negative regulation of regulatory T cell differentiation] GO:0045626[negative regulation of T-helper 1 cell differentiation] GO:0045630[positive regulation of T-helper 2 cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046641[positive regulation of alpha-beta T cell proliferation] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0050871[positive regulation of B cell activation] GO:0071222[cellular response to lipopolysaccharide] GO:0071380[cellular response to prostaglandin E stimulus] GO:1900281[positive regulation of CD4-positive, alpha-beta T cell costimulation] GO:2000572[positive regulation of interleukin-4-dependent isotype switching to IgE isotypes]
The Human Protein Atlas project is funded
