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                                          • NPHS2
                                          TISSUE PRIMARY DATA KIDNEY Show tissue menu
                                          ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
                                          DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
                                          NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
                                          SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
                                          ANTIBODIES
                                          AND
                                          VALIDATION
                                          Dictionary
                                          Kidney
                                          Tissue proteome
                                          Kidney
                                          Tissue methods
                                          KIDNEY - Expression summary
                                          Protein expression
                                          Kidneyi

                                          On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

                                          h
                                          m
                                          l
                                          n
                                          Bowman's capsule: Not detected
                                          Cells in glomeruli: High
                                          Collecting ducts: Not detected
                                          Distal tubules: Not detected
                                          Proximal tubules (cell body): Not detected
                                          Proximal tubules (microvilli): Not detected
                                          Protein profiling
                                          Multiplex tissuei

                                          A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

                                          Cytoplasmic staining in podocytes.

                                          RNA expressioni

                                          A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

                                          Scroll down to view mRNA expression data in more detail.

                                          Consensus:244.9 nTPM
                                          HPA:87.0 nTPM
                                          GTEx:244.9 nTPM
                                          FANTOM5:130.6 Scaled Tags Per Million
                                          KIDNEY - SINGLE CELL RNA EXPRESSION
                                          Explore single cell type data
                                          Renal collecting duct intercalated cellsRenal collecting duct principal cellsRenal connecting tubule cellsPodocytesProximal tubule cellsLoop of henle epithelial cellsPapillary tip epithelial cellsDistal convoluted tubule cellsVascular endothelial cellsLymphatic endothelial cellsPericytesVascular smooth muscle cellsFibroblastsMacrophagesT-cellsB-cellsNK-cells05001,0001,5002,0002,500nCPM

                                          KIDNEY - Multiplex stainingi

                                          Antibody localization in the annotated cell types/states/structures of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state/structure-specific markers, and, when applicable also subcellular localization. The scores are based on multiplex immunohistochemistry profiling in selected tissues.

                                          Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity, while additional locations are characterized by lower overlap and weaker antibody signal intensity.

                                          The antibody of interest is reported in green, while cell types/states/structures are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.

                                          - Antibody CAB037267
                                          Main location Podocytes
                                          No antibody overlap
                                          No antibody overlap
                                          No antibody overlap
                                          Antibody overlap>75%
                                          LocationCytoplasm
                                          No antibody overlap
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                                          KIDNEY - Antibody stainingi

                                          Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

                                          Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

                                          Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

                                          Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

                                          Antibody HPA049486Antibody CAB037267
                                          Bowman's capsule -Not detected
                                          Cells in glomeruli HighHigh
                                          Cells in tubules Not detected-
                                          Collecting ducts -Not detected
                                          Distal tubules -Not detected
                                          Proximal tubules (cell body) -Not detected
                                          Proximal tubules (microvilli) -Not detected




                                          KIDNEY - HPA RNA-seqi

                                          The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

                                          Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

                                          Average nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          87.0
                                          overview
                                          Female, age 58
                                          Kidney sample 55
                                          nTPM: 72.8
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          20

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 67
                                          Kidney sample 56
                                          nTPM: 81.2
                                          Cell types%
                                          Cells in tubules:
                                          70

                                          Cells in glomeruli:
                                          15

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          5

                                          overview
                                          Female, age 55
                                          Kidney sample 57
                                          nTPM: 30.8
                                          Cell types%
                                          Cells in tubules:
                                          80

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          5

                                          overview
                                          Male, age 46
                                          Kidney sample 58
                                          nTPM: 107.4
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          25

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          10

                                          overview
                                          Female, age 57
                                          Kidney sample 358
                                          nTPM: 88
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 78
                                          Kidney sample 377
                                          nTPM: 86.3
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          5

                                          Other cell types:
                                          20

                                          overview
                                          Male, age 73
                                          Kidney sample 380
                                          nTPM: 206.3
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          20

                                          overview
                                          Female, age 59
                                          Kidney sample 394
                                          nTPM: 59.8
                                          Cell types%
                                          Cells in tubules:
                                          65

                                          Cells in glomeruli:
                                          10

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          15

                                          overview
                                          Female, age 48
                                          Kidney sample 414
                                          nTPM: 50.3
                                          Cell types%
                                          Cells in tubules:
                                          60

                                          Cells in glomeruli:
                                          5

                                          Fibroblasts:
                                          10

                                          Other cell types:
                                          25


                                          KIDNEY - GTEx RNA-seqi

                                          RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

                                          Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

                                          Max subtype nTPMi

                                          Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

                                          244.9
                                          GTEx sample id Sample description nTPM
                                          126.5213.4341.30.0658.20100200300400500600700800
                                          126.5213.4341.30.0658.20100200300400500600700800
                                          Kidney - Cortex
                                          Average nTPM: 244.9
                                          Samples: 104

                                          Max nTPM: 836.1
                                          Min nTPM: 0.0
                                          Std nTPM: 180.4
                                          Median nTPM: 213.5
                                          GTEX-1C6VQ-2326-SM-7IGN1 50-59 years, male 836.1
                                          GTEX-1LG7Y-2726-SM-D5OVW 50-59 years, male 704.8
                                          GTEX-14C39-2126-SM-664OH 40-49 years, male 671.7
                                          GTEX-1HCU7-1826-SM-A9G2A 50-59 years, male 658.2
                                          GTEX-T6MN-1826-SM-EXOHN 50-59 years, male 600.8
                                          GTEX-1HCVE-2126-SM-HL9UO 50-59 years, male 577.3
                                          GTEX-1ICLY-2026-SM-GA913 50-59 years, male 567.5
                                          GTEX-1I1GP-1926-SM-CNNQU 50-59 years, male 557.8
                                          GTEX-13NYB-1726-SM-5N9G2 40-49 years, male 525.0
                                          GTEX-13FHP-2126-SM-GIN8J 50-59 years, male 513.0
                                          GTEX-14C5O-2026-SM-5YYB1 60-69 years, male 509.6
                                          GTEX-1JMLX-1526-SM-AHZ3N 50-59 years, male 506.5
                                          GTEX-16Z82-2826-SM-HAUZZ 60-69 years, male 489.9
                                          GTEX-1BAJH-1826-SM-731DA 70-79 years, male 488.3
                                          GTEX-1QP6S-1526-SM-EXUSG 40-49 years, male 470.4
                                          GTEX-14PJ2-1826-SM-HL9UB 50-59 years, male 458.9
                                          GTEX-1JJ6O-2526-SM-AHZ3J 60-69 years, male 441.0
                                          GTEX-15CHQ-2126-SM-6871M 60-69 years, male 430.5
                                          GTEX-1HB9E-1826-SM-D4P33 50-59 years, male 430.2
                                          GTEX-1A8FM-2026-SM-7P8RN 50-59 years, female 423.5
                                          GTEX-1KWVE-0826-SM-CXZKO 30-39 years, male 395.9
                                          GTEX-1117F-2126-SM-GIN9G 60-69 years, female 381.6
                                          GTEX-11OF3-1326-SM-5N9FJ 60-69 years, male 375.5
                                          GTEX-1GN1U-2126-SM-AHZ4J 50-59 years, female 356.5
                                          GTEX-14E6D-2526-SM-5YYA9 50-59 years, male 346.1
                                          GTEX-13RTJ-2226-SM-5S2Q1 60-69 years, male 344.2
                                          GTEX-1E2YA-1626-SM-7MGXS 50-59 years, male 340.3
                                          GTEX-16XZZ-2226-SM-HAV34 60-69 years, male 331.5
                                          GTEX-WL46-1926-SM-GNIN6 50-59 years, male 309.1
                                          GTEX-17F96-1926-SM-7MGWY 70-79 years, male 297.9
                                          GTEX-1GTWX-1826-SM-9QEHG 60-69 years, male 293.4
                                          GTEX-1RQEC-2426-SM-F2I1J 60-69 years, male 291.1
                                          GTEX-1GF9W-1326-SM-7P8PX 60-69 years, male 284.2
                                          GTEX-1NV8Z-2226-SM-EXOJ2 60-69 years, male 279.4
                                          GTEX-1H3VY-1926-SM-9JGHJ 50-59 years, male 272.5
                                          GTEX-14JG1-2326-SM-HAUZ5 40-49 years, male 263.9
                                          GTEX-1N2DW-1826-SM-EAZ54 50-59 years, male 261.3
                                          GTEX-1AX8Z-2326-SM-731CR 60-69 years, male 259.9
                                          GTEX-11GS4-2326-SM-5A5KS 60-69 years, male 258.2
                                          GTEX-NFK9-1826-SM-HL9T3 40-49 years, male 257.8
                                          GTEX-1H3NZ-2126-SM-9WPQ6 60-69 years, male 257.3
                                          GTEX-T5JC-1526-SM-4DM68 20-29 years, male 247.7
                                          GTEX-S33H-1426-SM-EZ6L7 30-39 years, male 242.8
                                          GTEX-13OW6-1826-SM-5N9F9 50-59 years, male 239.6
                                          GTEX-15DYW-2026-SM-6AJBD 60-69 years, female 238.0
                                          GTEX-13O1R-2526-SM-5N9FW 60-69 years, male 233.7
                                          GTEX-1497J-0826-SM-5NQAJ 60-69 years, male 231.5
                                          GTEX-Y5V5-1226-SM-EYYVP 60-69 years, female 230.0
                                          GTEX-1JMPZ-1226-SM-ARU8Y 30-39 years, male 229.0
                                          GTEX-1EKGG-2226-SM-7IGOA 60-69 years, male 220.8
                                          GTEX-1GF9V-1926-SM-9JGHE 60-69 years, male 216.2
                                          GTEX-1PWST-2226-SM-EVR3G 70-79 years, male 215.9
                                          GTEX-11TTK-1926-SM-5PNW8 60-69 years, female 211.0
                                          GTEX-1JJE9-1026-SM-HL9TH 70-79 years, male 207.3
                                          GTEX-1O9I2-1926-SM-F2TBQ 50-59 years, male 204.4
                                          GTEX-1HBPI-2026-SM-CE6RZ 50-59 years, male 200.9
                                          GTEX-17HHY-2326-SM-7KFSR 50-59 years, male 199.5
                                          GTEX-1CB4J-1926-SM-7MGX8 60-69 years, male 198.5
                                          GTEX-1F48J-2226-SM-7MXTN 50-59 years, female 192.6
                                          GTEX-17F97-1926-SM-7IGM4 50-59 years, male 192.0
                                          GTEX-15DCD-1926-SM-HAV33 70-79 years, female 189.8
                                          GTEX-16MT8-1926-SM-7EPGL 60-69 years, female 189.2
                                          GTEX-1JMQJ-1726-SM-E9U4V 50-59 years, male 188.7
                                          GTEX-1GMR3-2426-SM-7MXV2 40-49 years, male 181.1
                                          GTEX-REY6-1826-SM-EAZAT 60-69 years, male 179.5
                                          GTEX-13O3O-1726-SM-GJ3RL 60-69 years, female 176.9
                                          GTEX-P4QS-1126-SM-3NMD5 60-69 years, male 172.8
                                          GTEX-1R9PO-1626-SM-E6CPT 60-69 years, female 160.7
                                          GTEX-1N2EF-1426-SM-EXUSH 60-69 years, male 158.7
                                          GTEX-1J1OQ-1426-SM-AHZ3P 40-49 years, female 154.8
                                          GTEX-1A3MW-2226-SM-73KUX 60-69 years, female 151.8
                                          GTEX-1IKK5-0926-SM-A9G2U 60-69 years, male 151.8
                                          GTEX-145MN-0326-SM-5QGQI 30-39 years, male 141.7
                                          GTEX-XPVG-0526-SM-4B65N 50-59 years, male 137.4
                                          GTEX-12WSG-0826-SM-5EQ5A 50-59 years, female 133.7
                                          GTEX-1IL2V-1826-SM-ARU7R 70-79 years, male 131.7
                                          GTEX-Y5V6-2026-SM-5IFHO 60-69 years, male 131.7
                                          GTEX-1K9T9-1826-SM-CXZK2 50-59 years, female 127.8
                                          GTEX-1JMQK-1926-SM-CJI3B 60-69 years, male 122.6
                                          GTEX-QDT8-1726-SM-EYYV6 30-39 years, female 122.2
                                          GTEX-ZC5H-1726-SM-5HL7X 40-49 years, female 122.2
                                          GTEX-O5YV-1226-SM-EV795 60-69 years, female 116.8
                                          GTEX-1QAET-2126-SM-F2TBS 50-59 years, male 95.4
                                          GTEX-147F4-2626-SM-5Q5CS 50-59 years, male 78.9
                                          GTEX-QLQW-1626-SM-CMKFE 30-39 years, male 78.6
                                          GTEX-1MUQO-2526-SM-E9TJN 60-69 years, male 77.2
                                          GTEX-QDVN-1726-SM-HL9TO 50-59 years, male 73.7
                                          GTEX-ZDXO-0226-SM-4WKH7 60-69 years, male 73.2
                                          GTEX-ZVZP-0926-SM-5GIDB 50-59 years, male 40.6
                                          GTEX-1399S-0526-SM-5IJG8 30-39 years, female 35.6
                                          GTEX-16XZY-1026-SM-HAV39 70-79 years, male 34.6
                                          GTEX-ZYFG-1626-SM-5GZYY 60-69 years, female 29.3
                                          GTEX-13OVL-1826-SM-5KLZR 50-59 years, male 13.6
                                          GTEX-13OVI-1126-SM-5KLZF 60-69 years, female 11.9
                                          GTEX-12696-0926-SM-5FQTV 60-69 years, male 4.6
                                          GTEX-ZLFU-0926-SM-5P9F8 40-49 years, male 4.4
                                          GTEX-13112-2126-SM-5GCO4 50-59 years, male 0.9
                                          GTEX-1LH75-1326-SM-F2I1R 50-59 years, female 0.6
                                          GTEX-1OJC4-2326-SM-DTXA5 50-59 years, female 0.5
                                          GTEX-ZXG5-2026-SM-HAUZV 60-69 years, male 0.2
                                          GTEX-RN64-1626-SM-48FD7 50-59 years, male 0.1
                                          GTEX-W5X1-1626-SM-H7OGO 40-49 years, female 0.1
                                          GTEX-ZE9C-1426-SM-4WKGM 60-69 years, male 0.0
                                          GTEX-ZYT6-2226-SM-5GIC9 30-39 years, male 0.0
                                          Show allShow less
                                          0.20.9113.20.0232.9020406080100120140160180200220
                                          0.20.9113.20.0232.9020406080100120140160180200220
                                          Kidney - Medulla
                                          Average nTPM: 61.5
                                          Samples: 11

                                          Max nTPM: 232.9
                                          Min nTPM: 0.0
                                          Std nTPM: 93.3
                                          Median nTPM: 0.9
                                          GTEX-N7MS-1526-SM-HAUZP 60-69 years, male 232.9
                                          GTEX-P4QS-1226-SM-HPAG8 60-69 years, male 214.1
                                          GTEX-RU72-1926-SM-EAZ3F 50-59 years, female 189.7
                                          GTEX-TKQ2-0626-SM-EZ6LB 50-59 years, male 36.8
                                          GTEX-QEG5-2026-SM-H6Q6I 20-29 years, male 1.4
                                          GTEX-T6MN-1926-SM-GOQYD 50-59 years, male 0.9
                                          GTEX-QEG4-1526-SM-GPRWK 30-39 years, male 0.2
                                          GTEX-SIU8-1926-SM-H7OG4 50-59 years, male 0.2
                                          GTEX-S33H-1526-SM-GQ1CB 30-39 years, male 0.1
                                          GTEX-T5JC-1626-SM-EZ6KW 20-29 years, male 0.1
                                          GTEX-R55E-2026-SM-EZ6L1 20-29 years, male 0.0
                                          Show allShow less

                                          KIDNEY - FANTOM5 CAGEi

                                          RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

                                          Max subtype Scaled Tags Per Millioni

                                          Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

                                          130.6
                                          FANTOM5 sample id Sample description Scaled Tags Per Million
                                          Kidney
                                          Scaled Tags Per Million: 130.6
                                          FF:10017-101C8 60,62,63 years, female 130.6

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