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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q11.23
Chromosome location (bp)
73536356 - 73557690
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation 2. May play a role in lung tumor development or progression (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Differentiation, Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9BQE9 [Direct mapping] B-cell CLL/lymphoma 7 protein family member B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0003779[actin binding] GO:0005515[protein binding] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0008150[biological_process] GO:0008284[positive regulation of cell population proliferation] GO:0016055[Wnt signaling pathway] GO:0016514[SWI/SNF complex] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030154[cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0070316[regulation of G0 to G1 transition] GO:0140288[GBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Q9BQE9 [Direct mapping] B-cell CLL/lymphoma 7 protein family member B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0003779[actin binding] GO:0005515[protein binding] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0008150[biological_process] GO:0008284[positive regulation of cell population proliferation] GO:0016055[Wnt signaling pathway] GO:0016514[SWI/SNF complex] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030154[cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0070316[regulation of G0 to G1 transition] GO:0140288[GBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
F2Z3H6 [Direct mapping] B-cell CLL/lymphoma 7 protein family member B; B-cell CLL/lymphoma 7B, isoform CRA_a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Protein evidence (Ezkurdia et al 2014)
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GO:0006338[chromatin remodeling] GO:0008284[positive regulation of cell population proliferation] GO:0016514[SWI/SNF complex] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0045596[negative regulation of cell differentiation] GO:0070316[regulation of G0 to G1 transition] GO:0140288[GBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
The Human Protein Atlas project is funded
