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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
p13.3
Chromosome location (bp)
4425805 - 4456775
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q96EY1 [Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
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Q53G26 [Target identity:100%; Query identity:100%] DnaJ (Hsp40) homolog, subfamily A, member 3 variant; DnaJ (Hsp40) homolog, subfamily A, member 3, isoform CRA_b
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005133[interferon-gamma receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0006264[mitochondrial DNA replication] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0007005[mitochondrion organization] GO:0007264[small GTPase mediated signal transduction] GO:0007528[neuromuscular junction development] GO:0008285[negative regulation of cell population proliferation] GO:0009408[response to heat] GO:0016020[membrane] GO:0019897[extrinsic component of plasma membrane] GO:0019901[protein kinase binding] GO:0030544[Hsp70 protein binding] GO:0030695[GTPase regulator activity] GO:0031072[heat shock protein binding] GO:0031594[neuromuscular junction] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0033077[T cell differentiation in thymus] GO:0034341[response to type II interferon] GO:0042102[positive regulation of T cell proliferation] GO:0042645[mitochondrial nucleoid] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043069[negative regulation of programmed cell death] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231[intracellular membrane-bounded organelle] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045211[postsynaptic membrane] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051059[NF-kappaB binding] GO:0051082[unfolded protein binding] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071340[skeletal muscle acetylcholine-gated channel clustering] GO:0090398[cellular senescence] GO:0106137[IkappaB kinase complex binding] GO:0140297[DNA-binding transcription factor binding]
Q96EY1 [Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0005133[interferon-gamma receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0007005[mitochondrion organization] GO:0007528[neuromuscular junction development] GO:0008285[negative regulation of cell population proliferation] GO:0009408[response to heat] GO:0016020[membrane] GO:0019897[extrinsic component of plasma membrane] GO:0019901[protein kinase binding] GO:0031072[heat shock protein binding] GO:0031398[positive regulation of protein ubiquitination] GO:0031594[neuromuscular junction] GO:0034341[response to type II interferon] GO:0042645[mitochondrial nucleoid] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045211[postsynaptic membrane] GO:0046872[metal ion binding] GO:0051059[NF-kappaB binding] GO:0051082[unfolded protein binding] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0071340[skeletal muscle acetylcholine-gated channel clustering] GO:0106137[IkappaB kinase complex binding]
Q96EY1 [Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
