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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q23.3
Chromosome location (bp)
83968244 - 84002776
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q7Z6G3 [Direct mapping] N-terminal EF-hand calcium-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0016020[membrane] GO:0030424[axon] GO:0030425[dendrite] GO:0031687[A2A adenosine receptor binding] GO:0031802[type 5 metabotropic glutamate receptor binding] GO:0042984[regulation of amyloid precursor protein biosynthetic process] GO:0042995[cell projection] GO:0046872[metal ion binding] GO:0060168[positive regulation of adenosine receptor signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:1900451[positive regulation of glutamate receptor signaling pathway] GO:1904021[negative regulation of G protein-coupled receptor internalization] GO:1905477[positive regulation of protein localization to membrane]
Q7Z6G3 [Direct mapping] N-terminal EF-hand calcium-binding protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0016020[membrane] GO:0030424[axon] GO:0030425[dendrite] GO:0031687[A2A adenosine receptor binding] GO:0031802[type 5 metabotropic glutamate receptor binding] GO:0042802[identical protein binding] GO:0042984[regulation of amyloid precursor protein biosynthetic process] GO:0042995[cell projection] GO:0046872[metal ion binding] GO:0060168[positive regulation of adenosine receptor signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:1900451[positive regulation of glutamate receptor signaling pathway] GO:1904021[negative regulation of G protein-coupled receptor internalization] GO:1905477[positive regulation of protein localization to membrane]
The Human Protein Atlas project is funded
