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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.2
Chromosome location (bp)
138187650 - 138213343
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle 1. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains 2. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins 3....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UJX2 [Direct mapping] Cell division cycle protein 23 homolog
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0007080[mitotic metaphase plate congression] GO:0007091[metaphase/anaphase transition of mitotic cell cycle] GO:0007096[regulation of exit from mitosis] GO:0007346[regulation of mitotic cell cycle] GO:0016567[protein ubiquitination] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0045842[positive regulation of mitotic metaphase/anaphase transition] GO:0051301[cell division] GO:0051445[regulation of meiotic cell cycle] GO:0070979[protein K11-linked ubiquitination]
Q9UJX2 [Direct mapping] Cell division cycle protein 23 homolog
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007049[cell cycle] GO:0007080[mitotic metaphase plate congression] GO:0007091[metaphase/anaphase transition of mitotic cell cycle] GO:0007096[regulation of exit from mitosis] GO:0007346[regulation of mitotic cell cycle] GO:0016567[protein ubiquitination] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0045842[positive regulation of mitotic metaphase/anaphase transition] GO:0051301[cell division] GO:0051445[regulation of meiotic cell cycle] GO:0070979[protein K11-linked ubiquitination]
D6RCF8 [Direct mapping] Cell division cycle protein 23 homolog
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
