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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q27.1
Chromosome location (bp)
184371935 - 184381968
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Hormone
Gene summary (Entrez)i
Useful information about the gene from Entrez
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005179[hormone activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0030219[megakaryocyte differentiation] GO:0035855[megakaryocyte development] GO:0038163[thrombopoietin-mediated signaling pathway] GO:0043410[positive regulation of MAPK cascade] GO:0045654[positive regulation of megakaryocyte differentiation] GO:0050896[response to stimulus] GO:0051897[positive regulation of protein kinase B signaling] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0097696[receptor signaling pathway via STAT] GO:1902035[positive regulation of hematopoietic stem cell proliferation]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005179[hormone activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0030219[megakaryocyte differentiation] GO:0032496[response to lipopolysaccharide] GO:0035855[megakaryocyte development] GO:0038163[thrombopoietin-mediated signaling pathway] GO:0043410[positive regulation of MAPK cascade] GO:0045654[positive regulation of megakaryocyte differentiation] GO:0050896[response to stimulus] GO:0051897[positive regulation of protein kinase B signaling] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:0097696[receptor signaling pathway via STAT] GO:1902035[positive regulation of hematopoietic stem cell proliferation]
The Human Protein Atlas project is funded
