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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.11
Chromosome location (bp)
47734363 - 47771040
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
cAMP, cAMP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including positive regulation of protein modification process; regulation of actin cytoskeleton organization; and regulation of syncytium formation by plasma membrane fusion. Located in filopodium; lamellipodium; and microvillus. Colocalizes with cortical actin cytoskeleton and plasma membrane. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002250[adaptive immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0019933[cAMP-mediated signaling] GO:0030027[lamellipodium] GO:0030175[filopodium] GO:0030552[cAMP binding] GO:0030864[cortical actin cytoskeleton] GO:0032486[Rap protein signal transduction] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034242[negative regulation of syncytium formation by plasma membrane fusion] GO:0035556[intracellular signal transduction] GO:0043547[positive regulation of GTPase activity] GO:0045766[positive regulation of angiogenesis] GO:0046827[positive regulation of protein export from nucleus] GO:0051496[positive regulation of stress fiber assembly] GO:0060143[positive regulation of syncytium formation by plasma membrane fusion] GO:0061028[establishment of endothelial barrier] GO:0070062[extracellular exosome] GO:0071320[cellular response to cAMP] GO:1901985[positive regulation of protein acetylation] GO:2000249[regulation of actin cytoskeleton reorganization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002250[adaptive immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0019933[cAMP-mediated signaling] GO:0030027[lamellipodium] GO:0030175[filopodium] GO:0030552[cAMP binding] GO:0030864[cortical actin cytoskeleton] GO:0032486[Rap protein signal transduction] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034242[negative regulation of syncytium formation by plasma membrane fusion] GO:0035556[intracellular signal transduction] GO:0043547[positive regulation of GTPase activity] GO:0045766[positive regulation of angiogenesis] GO:0046827[positive regulation of protein export from nucleus] GO:0051496[positive regulation of stress fiber assembly] GO:0060143[positive regulation of syncytium formation by plasma membrane fusion] GO:0061028[establishment of endothelial barrier] GO:0070062[extracellular exosome] GO:0071320[cellular response to cAMP] GO:1901985[positive regulation of protein acetylation] GO:2000249[regulation of actin cytoskeleton reorganization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002250[adaptive immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0019933[cAMP-mediated signaling] GO:0030027[lamellipodium] GO:0030175[filopodium] GO:0030552[cAMP binding] GO:0030864[cortical actin cytoskeleton] GO:0032486[Rap protein signal transduction] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034242[negative regulation of syncytium formation by plasma membrane fusion] GO:0035556[intracellular signal transduction] GO:0043547[positive regulation of GTPase activity] GO:0045766[positive regulation of angiogenesis] GO:0046827[positive regulation of protein export from nucleus] GO:0051496[positive regulation of stress fiber assembly] GO:0060143[positive regulation of syncytium formation by plasma membrane fusion] GO:0061028[establishment of endothelial barrier] GO:0070062[extracellular exosome] GO:0071320[cellular response to cAMP] GO:1901985[positive regulation of protein acetylation] GO:2000249[regulation of actin cytoskeleton reorganization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002250[adaptive immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008306[associative learning] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0019933[cAMP-mediated signaling] GO:0030027[lamellipodium] GO:0030175[filopodium] GO:0030552[cAMP binding] GO:0030864[cortical actin cytoskeleton] GO:0032486[Rap protein signal transduction] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034242[negative regulation of syncytium formation by plasma membrane fusion] GO:0035556[intracellular signal transduction] GO:0043547[positive regulation of GTPase activity] GO:0045766[positive regulation of angiogenesis] GO:0046827[positive regulation of protein export from nucleus] GO:0051496[positive regulation of stress fiber assembly] GO:0060143[positive regulation of syncytium formation by plasma membrane fusion] GO:0061028[establishment of endothelial barrier] GO:0070062[extracellular exosome] GO:0071320[cellular response to cAMP] GO:1901985[positive regulation of protein acetylation] GO:2000249[regulation of actin cytoskeleton reorganization]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002250[adaptive immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0012505[endomembrane system] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0019933[cAMP-mediated signaling] GO:0030027[lamellipodium] GO:0030175[filopodium] GO:0030552[cAMP binding] GO:0030864[cortical actin cytoskeleton] GO:0032486[Rap protein signal transduction] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034242[negative regulation of syncytium formation by plasma membrane fusion] GO:0035556[intracellular signal transduction] GO:0043547[positive regulation of GTPase activity] GO:0045766[positive regulation of angiogenesis] GO:0046827[positive regulation of protein export from nucleus] GO:0051496[positive regulation of stress fiber assembly] GO:0060143[positive regulation of syncytium formation by plasma membrane fusion] GO:0061028[establishment of endothelial barrier] GO:0070062[extracellular exosome] GO:0071320[cellular response to cAMP] GO:1901985[positive regulation of protein acetylation] GO:2000249[regulation of actin cytoskeleton reorganization]
The Human Protein Atlas project is funded
