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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q29
Chromosome location (bp)
197042560 - 197299330
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane 1....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001657[ureteric bud development] GO:0001658[branching involved in ureteric bud morphogenesis] GO:0001771[immunological synapse formation] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0002088[lens development in camera-type eye] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005604[basement membrane] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008104[protein localization] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016328[lateral plasma membrane] GO:0019900[kinase binding] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030041[actin filament polymerization] GO:0030054[cell junction] GO:0030432[peristalsis] GO:0030838[positive regulation of actin filament polymerization] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031253[cell projection membrane] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031579[membrane raft organization] GO:0031594[neuromuscular junction] GO:0031641[regulation of myelination] GO:0032147[activation of protein kinase activity] GO:0033268[node of Ranvier] GO:0035748[myelin sheath abaxonal region] GO:0042098[T cell proliferation] GO:0042110[T cell activation] GO:0042130[negative regulation of T cell proliferation] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0042982[amyloid precursor protein metabolic process] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043219[lateral loop] GO:0043268[positive regulation of potassium ion transport] GO:0043491[protein kinase B signaling] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045121[membrane raft] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0048608[reproductive structure development] GO:0048704[embryonic skeletal system morphogenesis] GO:0048729[tissue morphogenesis] GO:0048745[smooth muscle tissue development] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051660[establishment of centrosome localization] GO:0051898[negative regulation of protein kinase B signaling] GO:0060022[hard palate development] GO:0060090[molecular adaptor activity] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0098919[structural constituent of postsynaptic density] GO:0098978[glutamatergic synapse] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001772[immunological synapse] GO:0001935[endothelial cell proliferation] GO:0004385[guanylate kinase activity] GO:0004721[phosphoprotein phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005912[adherens junction] GO:0005923[bicellular tight junction] GO:0007015[actin filament organization] GO:0007163[establishment or maintenance of cell polarity] GO:0007268[chemical synaptic transmission] GO:0008022[protein C-terminus binding] GO:0008092[cytoskeletal protein binding] GO:0008360[regulation of cell shape] GO:0009898[cytoplasmic side of plasma membrane] GO:0014069[postsynaptic density] GO:0014704[intercalated disc] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0019901[protein kinase binding] GO:0019902[phosphatase binding] GO:0030054[cell junction] GO:0030866[cortical actin cytoskeleton organization] GO:0030953[astral microtubule organization] GO:0031434[mitogen-activated protein kinase kinase binding] GO:0031503[protein-containing complex localization] GO:0031594[neuromuscular junction] GO:0042383[sarcolemma] GO:0042391[regulation of membrane potential] GO:0043005[neuron projection] GO:0043113[receptor clustering] GO:0043268[positive regulation of potassium ion transport] GO:0043622[cortical microtubule organization] GO:0044325[transmembrane transporter binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0046037[GMP metabolic process] GO:0046710[GDP metabolic process] GO:0048471[perinuclear region of cytoplasm] GO:0051660[establishment of centrosome localization] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070830[bicellular tight junction assembly] GO:0072659[protein localization to plasma membrane] GO:0097016[L27 domain binding] GO:0097025[MPP7-DLG1-LIN7 complex] GO:0097060[synaptic membrane] GO:0097120[receptor localization to synapse] GO:0098609[cell-cell adhesion] GO:0098839[postsynaptic density membrane] GO:0098911[regulation of ventricular cardiac muscle cell action potential] GO:0099562[maintenance of postsynaptic density structure] GO:0099645[neurotransmitter receptor localization to postsynaptic specialization membrane] GO:1902305[regulation of sodium ion transmembrane transport] GO:1902473[regulation of protein localization to synapse] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903286[regulation of potassium ion import] GO:1903753[negative regulation of p38MAPK cascade] GO:1903760[regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization] GO:1903764[regulation of potassium ion export across plasma membrane] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]