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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q33.1
Chromosome location (bp)
201233443 - 201361836
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood 1,2,3,4,5,6,7,8. Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death 9,10,11,12,13,14,15,16. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 17,18,19. Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A 20,21. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation 22. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases 23. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC 24. In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response 25,26. Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis 27,28. Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways 29. Cleaves PARP1 and PARP2 30. Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 31,32....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protease, Thiol protease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088[regulation of innate immune response] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088[regulation of innate immune response] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088[regulation of innate immune response] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088[regulation of innate immune response] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088[regulation of innate immune response] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045088[regulation of innate immune response] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001817[regulation of cytokine production] GO:0004197[cysteine-type endopeptidase activity] GO:0005123[death receptor binding] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007507[heart development] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0009409[response to cold] GO:0010803[regulation of tumor necrosis factor-mediated signaling pathway] GO:0016485[protein processing] GO:0016787[hydrolase activity] GO:0030101[natural killer cell activation] GO:0030225[macrophage differentiation] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0031625[ubiquitin protein ligase binding] GO:0032025[response to cobalt ion] GO:0032355[response to estradiol] GO:0032496[response to lipopolysaccharide] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0034612[response to tumor necrosis factor] GO:0035877[death effector domain binding] GO:0036462[TRAIL-activated apoptotic signaling pathway] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043005[neuron projection] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044297[cell body] GO:0044877[protein-containing complex binding] GO:0045088[regulation of innate immune response] GO:0045121[membrane raft] GO:0045471[response to ethanol] GO:0045651[positive regulation of macrophage differentiation] GO:0045862[positive regulation of proteolysis] GO:0046677[response to antibiotic] GO:0051603[proteolysis involved in protein catabolic process] GO:0060546[negative regulation of necroptotic process] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070269[pyroptosis] GO:0071260[cellular response to mechanical stimulus] GO:0071407[cellular response to organic cyclic compound] GO:0097110[scaffold protein binding] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202[activation of cysteine-type endopeptidase activity] GO:0097264[self proteolysis] GO:0097342[ripoptosome] GO:1901216[positive regulation of neuron death]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
