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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q21.33
Chromosome location (bp)
63655197 - 63661893
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protease inhibitor, Serine protease inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Located in cytoplasmic vesicle; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001618[virus receptor activity] GO:0002020[protease binding] GO:0004867[serine-type endopeptidase inhibitor activity] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0008284[positive regulation of cell population proliferation] GO:0010466[negative regulation of peptidase activity] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010950[positive regulation of endopeptidase activity] GO:0010951[negative regulation of endopeptidase activity] GO:0030335[positive regulation of cell migration] GO:0030414[peptidase inhibitor activity] GO:0031410[cytoplasmic vesicle] GO:0031982[vesicle] GO:0035425[autocrine signaling] GO:0035578[azurophil granule lumen] GO:0038001[paracrine signaling] GO:0043086[negative regulation of catalytic activity] GO:0043508[negative regulation of JUN kinase activity] GO:0045861[negative regulation of proteolysis] GO:0046718[viral entry into host cell] GO:0070062[extracellular exosome]
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618[virus receptor activity] GO:0002020[protease binding] GO:0004867[serine-type endopeptidase inhibitor activity] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0008284[positive regulation of cell population proliferation] GO:0010466[negative regulation of peptidase activity] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010950[positive regulation of endopeptidase activity] GO:0010951[negative regulation of endopeptidase activity] GO:0030335[positive regulation of cell migration] GO:0030414[peptidase inhibitor activity] GO:0031410[cytoplasmic vesicle] GO:0031982[vesicle] GO:0035425[autocrine signaling] GO:0035578[azurophil granule lumen] GO:0038001[paracrine signaling] GO:0043086[negative regulation of catalytic activity] GO:0043508[negative regulation of JUN kinase activity] GO:0045861[negative regulation of proteolysis] GO:0046718[viral entry into host cell] GO:0070062[extracellular exosome]
The Human Protein Atlas project is funded
