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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Disease related genes FDA approved drug targets Human disease related genes Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.31
Chromosome location (bp)
6786858 - 6820799
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Host cell receptor for virus entry, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001618[virus receptor activity] GO:0001934[positive regulation of protein phosphorylation] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0004888[transmembrane signaling receptor activity] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005769[early endosome] GO:0005788[endoplasmic reticulum lumen] GO:0005789[endoplasmic reticulum membrane] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007167[enzyme-linked receptor protein signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0015026[coreceptor activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019722[calcium-mediated signaling] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0023026[MHC class II protein complex binding] GO:0030217[T cell differentiation] GO:0030225[macrophage differentiation] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0032507[maintenance of protein location in cell] GO:0032743[positive regulation of interleukin-2 production] GO:0033674[positive regulation of kinase activity] GO:0035397[helper T cell enhancement of adaptive immune response] GO:0035723[interleukin-15-mediated signaling pathway] GO:0038023[signaling receptor activity] GO:0042011[interleukin-16 binding] GO:0042012[interleukin-16 receptor activity] GO:0042101[T cell receptor complex] GO:0042110[T cell activation] GO:0042289[MHC class II protein binding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410[positive regulation of MAPK cascade] GO:0045058[T cell selection] GO:0045121[membrane raft] GO:0045657[positive regulation of monocyte differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0045893[positive regulation of DNA-templated transcription] GO:0046598[positive regulation of viral entry into host cell] GO:0046718[viral entry into host cell] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050829[defense response to Gram-negative bacterium] GO:0050850[positive regulation of calcium-mediated signaling] GO:0050863[regulation of T cell activation] GO:0050870[positive regulation of T cell activation] GO:0050896[response to stimulus] GO:0051924[regulation of calcium ion transport] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0097011[cellular response to granulocyte macrophage colony-stimulating factor stimulus] GO:1990782[protein tyrosine kinase binding]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
