Nucleoli fibrillar center

The nucleolar fibrillar center (FC) is a subcompartment of the nucleolus with a clear fibrillar structure, assembled around active nucleolar organizing regions (NORs) at certain chromosomal loci. Transcription of rDNA occurs at the border of fibrillar centers and the surrounding dense fibrillar component, while the fibrillar centers themselves harbour the non-transcribed copies of rDNAs, as well as the RNA polymerase I complexes, and other parts of the transcription machinery.

Immunofluorescent staining

The nucleoli fibrillar center, and/or dense fibrillar component, can appear as a spotty cluster or as a single big spot inside the nucleolus, depending on the cell line.

Read more about the proteome of the nucleoli fibrillar center as a substructure of nucleoli.

NOLC1

Nucleolar and coiled-body phosphoprotein 1 (NOLC1) connects RNA polymerase I (which replicates ribosomal RNA inside the nucleoli) with enzymes that are responsible for ribosomal processing and modification.

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Staining of NOLC1 in HEK293 ( HPA050388 )