Protein structures

The three-dimensional structure of a protein is directly correlated with its function and of major importance for understanding biological processes and the possibilities for interaction with other proteins. Knowing the structure is also important for understanding how the function could be modulated e.g. for therapeutic purposes.

The Structure section contains information about the predicted three-dimensional structure of 19904 human proteins and their related isoforms. Interactive 3D protein structures based on predictions generated using the AlphaFold source code are shown with the possibility to highlight selected regions and positions in the structure. The Protein Browser tool displays a variety of features for the different isoforms and can be used to select splice variants and highlight protein related features such as known antigen sequences, transmembrane regions and InterPro domains directly on the structures. The amino acid positions of population variants and variants with known clinical relevance in the Ensembl Variation database as well as predicted benign and pathological variants from AlphaMissense can also be displayed. More information about the specific content and the generation and analysis of the data in the section can be found in the Methods Summary.

Learn about:

the predicted 3D structure of proteins and their related isoforms
the antigen structure for the majority of the antibodies
the predicted structure of selected protein features
the known and predicted missense variants with clinical significance
the known population variants and predicted benign missense variants

PREDICTED STRUCTURE

View the structures of EGFR in the Human Protein Atlas

The predicted structure of the epidermal growth factor receptor EGFR colored according to a per-residue confidence score (pLDDT) with dark blue representing the highest confidence and orange the lowest confidence.

ANTIGEN STRUCTURE

View the structures of EGFR in the Human Protein Atlas

The predicted structure of the epidermal growth factor receptor EGFR with the sequences of the antigens used to generate the antibodies displayed in red and green.

KNOWN POPULATION VARIANTS

View the structures of EGFR in the Human Protein Atlas

The predicted structure of the epidermal growth factor receptor EGFR with population variants from Ensembl Variation marked in blue.

KNOWN CLINICAL VARIANTS

View the structures of EGFR in the Human Protein Atlas

The predicted structure of the epidermal growth factor receptor EGFR with variants classified as pathogenic or likely pathogenic in the Ensembl Variation clinical data set marked in blue.

PREDICTED BENIGN VARIANTS

View the structures of EGFR in the Human Protein Atlas

The predicted structure of the epidermal growth factor receptor EGFR with "likely benign" missense variants according to AlphaMissense predictions marked in blue.

PREDICTED PATHOGENIC VARIANTS

View the structures of EGFR in the Human Protein Atlas

The predicted structure of the epidermal growth factor receptor EGFR with "likely pathogenic" missense variants according to AlphaMissense predictions marked in blue.