Kidney cancer

The upper left dot plot(s) shows the consistency between the cancer type related cell lines and their corresponding TCGA disease cohort based on Spearman correlation and normalized enrichment score (NES). In the lower left is a list of the cell lines ranked according to their similarity to the cancer type. By clicking on a cell line in the dot plot or in the ranked list lollipop plots showing the activity of cancer-related pathways inferred using PROGENy and CytoSig cytokines for that particular cell line will be displayed. For more details about the analysis see Methods summary and information about all cell lines can be found here.

Kidney Chromophobe (KICH)

Explore the disease cohort in TCGA

HCC89CAL-54KMRC-3KMRC-20SLR21TUHR14TKBUO-31VMRC-RCZSNU-1272RCC10RGBSNU-349Caki-2ACHNVMRC-RCWSLR24TUHR10TKBTUHR4TKBHCC1011769-PHCC1319SK-RC-20OS-RC-2Caki-1TK-10SLR26A-704A-498SLR23SLR25KMRC-2UOK101BFTC-909786-OKMRC-1G-4020.720.740.76Spearman's ฯ0.811.21.4NES
Ranking
Cell line
Corr
NES
1 HCC89 0.76 1.31
1 CAL-54 0.76 1.43
3 KMRC-3 0.75 1.31
4 KMRC-20 0.76 1.3
5 SLR21 0.75 1.31
6 TUHR14TKB 0.76 1.19
6 UO-31 0.76 1.17
8 VMRC-RCZ 0.75 1.22
9 SNU-1272 0.75 1.19
9 RCC10RGB 0.74 1.24
11 SNU-349 0.75 1.22
12 Caki-2 0.74 1.22
12 ACHN 0.74 1.26
14 VMRC-RCW 0.75 1.1
14 SLR24 0.74 1.21
16 TUHR10TKB 0.74 1.13
17 TUHR4TKB 0.75 1.02
18 HCC1011 0.74 1.12
18 769-P 0.75 1.08
20 HCC1319 0.74 1.13
21 SK-RC-20 0.74 1.06
22 OS-RC-2 0.74 1.18
23 Caki-1 0.74 1.02
24 TK-10 0.74 1.09
24 SLR26 0.74 1.08
26 A-704 0.71 1.15
27 A-498 0.74 0.97
28 SLR23 0.74 0.93
29 SLR25 0.73 1.08
30 KMRC-2 0.74 0.98
30 UOK101 0.74 0.84
32 BFTC-909 0.74 0.91
33 786-O 0.74 0.73
34 KMRC-1 0.73 0.88
35 G-402 0.7 0.75
CELL LINE DATA
Cell line HCC89
Patient:
Disease subtype: Rel Cell Carcinoma
Primary/metastasis:
Sample collection site:
Cellosaurus: CVCL_V731
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-2-10123Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-505101520Z-score

Kidney Renal Clear Cell Carcinoma (KIRC)

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HCC89TUHR4TKBSLR21KMRC-3SNU-1272KMRC-20TUHR14TKBOS-RC-2VMRC-RCZSLR24SNU-349CAL-54RCC10RGBHCC1011TUHR10TKBHCC1319VMRC-RCW769-PSLR26UO-31KMRC-2Caki-2SLR23SK-RC-20Caki-1A-498A-704TK-10ACHNUOK101786-OKMRC-1SLR25BFTC-909G-4020.70.720.740.76Spearman's ฯ1.21.41.61.82NES
Ranking
Cell line
Corr
NES
1 HCC89 0.77 2.01
2 TUHR4TKB 0.76 1.95
2 SLR21 0.76 1.99
4 KMRC-3 0.76 1.97
5 SNU-1272 0.76 1.93
6 KMRC-20 0.76 1.9
7 TUHR14TKB 0.76 1.85
7 OS-RC-2 0.75 2.03
9 VMRC-RCZ 0.75 1.9
9 SLR24 0.75 2.02
11 SNU-349 0.75 1.86
12 CAL-54 0.76 1.83
13 RCC10RGB 0.75 1.85
14 HCC1011 0.75 1.89
15 TUHR10TKB 0.75 1.84
16 HCC1319 0.74 1.88
16 VMRC-RCW 0.76 1.72
18 769-P 0.75 1.76
19 SLR26 0.75 1.81
19 UO-31 0.75 1.35
21 KMRC-2 0.74 1.83
22 Caki-2 0.74 1.83
23 SLR23 0.75 1.72
23 SK-RC-20 0.75 1.59
25 Caki-1 0.75 1.69
26 A-498 0.74 1.73
27 A-704 0.72 1.84
28 TK-10 0.73 1.78
29 ACHN 0.74 1.69
30 UOK101 0.74 1.67
31 786-O 0.74 1.61
32 KMRC-1 0.73 1.41
33 SLR25 0.73 1.35
34 BFTC-909 0.73 1.05
35 G-402 0.68 1.14
CELL LINE DATA
Cell line HCC89
Patient:
Disease subtype: Rel Cell Carcinoma
Primary/metastasis:
Sample collection site:
Cellosaurus: CVCL_V731
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-2-10123Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-505101520Z-score

Kidney Renal Papillary Cell Carcinoma (KIRP)

Explore the disease cohort in TCGA

SLR21CAL-54HCC89TUHR14TKBKMRC-20TUHR4TKBSLR24SNU-1272VMRC-RCZ769-PCaki-2ACHNKMRC-3RCC10RGBVMRC-RCWSLR23TK-10UO-31OS-RC-2SLR26Caki-1SK-RC-20HCC1011KMRC-2A-498UOK101A-704TUHR10TKBSNU-349HCC1319786-OSLR25KMRC-1BFTC-909G-4020.720.740.760.78Spearman's ฯ11.52NES
Ranking
Cell line
Corr
NES
1 SLR21 0.79 2.22
2 CAL-54 0.79 2.17
3 HCC89 0.78 1.95
3 TUHR14TKB 0.78 1.93
5 KMRC-20 0.78 1.94
6 TUHR4TKB 0.78 1.9
6 SLR24 0.77 2.11
6 SNU-1272 0.77 1.96
6 VMRC-RCZ 0.77 2.06
6 769-P 0.77 1.97
11 Caki-2 0.77 2.07
12 ACHN 0.77 1.97
13 KMRC-3 0.78 1.83
13 RCC10RGB 0.77 1.88
15 VMRC-RCW 0.77 1.83
16 SLR23 0.77 1.87
17 TK-10 0.76 1.95
17 UO-31 0.78 1.66
19 OS-RC-2 0.76 1.9
19 SLR26 0.76 1.88
21 Caki-1 0.76 1.84
22 SK-RC-20 0.76 1.7
22 HCC1011 0.76 1.82
24 KMRC-2 0.76 1.78
24 A-498 0.76 1.74
24 UOK101 0.76 1.79
24 A-704 0.74 1.84
28 TUHR10TKB 0.76 1.54
29 SNU-349 0.76 1.56
30 HCC1319 0.75 1.61
31 786-O 0.75 1.57
32 SLR25 0.74 1.41
33 KMRC-1 0.75 1.25
34 BFTC-909 0.74 1.29
35 G-402 0.7 0.9
CELL LINE DATA
Cell line SLR21
Patient: Female
Disease subtype: Renal Cell Carcinoma
Primary/metastasis: Metastasis
Sample collection site: Kidney
Cellosaurus: CVCL_V607
PROGENy
AndrogenEGFREstrogenHypoxiaJAK-STATMAPKNFkBp53PI3KTGFbTNFaTrailVEGFWNTNES-1.5-1.0-0.50.00.51.01.5Z-scoreSignificant - upregulatedSignificant - downregulatedNon significant
CytoSig
Activin ABDNFBMP2BMP4BMP6CD40LCXCL12EGFFGF2GCSFGDF11GMCSFHGFIFN1IFNGIFNLIL10IL12IL13IL15IL17AIL1AIL1BIL2IL21IL22IL27IL3IL36IL4IL6LIFLTAMCSFNOOSMTGFB1TGFB3TNFATRAILTWEAKVEGFAWNT3ANES-10-5051015Z-score