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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q24
Chromosome location (bp)
120594010 - 120621159
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation 1,2,3. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent 4,5,6. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair 7,8,9,10,11,12,13,14. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2 15....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Initiation factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, DNA damage, Growth regulation, Protein biosynthesis, Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Predicted to enable translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Located in cytosol and plasma membrane. Colocalizes with cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001731[formation of translation preinitiation complex] GO:0003723[RNA binding] GO:0003743[translation initiation factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006412[translation] GO:0006413[translational initiation] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0008284[positive regulation of cell population proliferation] GO:0022627[cytosolic small ribosomal subunit] GO:0032790[ribosome disassembly] GO:0075522[IRES-dependent viral translational initiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731[formation of translation preinitiation complex] GO:0003723[RNA binding] GO:0003743[translation initiation factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006412[translation] GO:0006413[translational initiation] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0008284[positive regulation of cell population proliferation] GO:0022627[cytosolic small ribosomal subunit] GO:0032790[ribosome disassembly] GO:0075522[IRES-dependent viral translational initiation]
The Human Protein Atlas project is funded
