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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.12
Chromosome location (bp)
92322581 - 92501481
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) 1,2. Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (By similarity). May play a role in calcium transport during amelogenesis 3,4....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Antiport, Calcium transport, Ion transport, Olfaction, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Potassium, Sodium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) DeepTMHMM predicted membrane proteins
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GO:0005262[calcium channel activity] GO:0005516[calmodulin binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006816[calcium ion transport] GO:0006874[cellular calcium ion homeostasis] GO:0007602[phototransduction] GO:0007608[sensory perception of smell] GO:0008273[calcium, potassium:sodium antiporter activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009644[response to high light intensity] GO:0010469[regulation of signaling receptor activity] GO:0015293[symporter activity] GO:0015297[antiporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0021630[olfactory nerve maturation] GO:0031982[vesicle] GO:0035725[sodium ion transmembrane transport] GO:0036368[cone photoresponse recovery] GO:0042756[drinking behavior] GO:0048306[calcium-dependent protein binding] GO:0050849[negative regulation of calcium-mediated signaling] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0055074[calcium ion homeostasis] GO:0055085[transmembrane transport] GO:0070166[enamel mineralization] GO:0070588[calcium ion transmembrane transport] GO:0071805[potassium ion transmembrane transport] GO:0086009[membrane repolarization] GO:0097186[amelogenesis] GO:0098703[calcium ion import across plasma membrane] GO:0120199[cone photoreceptor outer segment] GO:1903998[regulation of eating behavior] GO:1990034[calcium ion export across plasma membrane] GO:1990680[response to melanocyte-stimulating hormone] GO:1990834[response to odorant]
Metabolic proteins Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0005262[calcium channel activity] GO:0005516[calmodulin binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006816[calcium ion transport] GO:0006874[cellular calcium ion homeostasis] GO:0007602[phototransduction] GO:0007608[sensory perception of smell] GO:0008273[calcium, potassium:sodium antiporter activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009644[response to high light intensity] GO:0010469[regulation of signaling receptor activity] GO:0015293[symporter activity] GO:0015297[antiporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0021630[olfactory nerve maturation] GO:0031982[vesicle] GO:0035725[sodium ion transmembrane transport] GO:0036368[cone photoresponse recovery] GO:0042756[drinking behavior] GO:0048306[calcium-dependent protein binding] GO:0050849[negative regulation of calcium-mediated signaling] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0055074[calcium ion homeostasis] GO:0055085[transmembrane transport] GO:0070166[enamel mineralization] GO:0070588[calcium ion transmembrane transport] GO:0071805[potassium ion transmembrane transport] GO:0086009[membrane repolarization] GO:0097186[amelogenesis] GO:0098703[calcium ion import across plasma membrane] GO:0120199[cone photoreceptor outer segment] GO:1903998[regulation of eating behavior] GO:1990034[calcium ion export across plasma membrane] GO:1990680[response to melanocyte-stimulating hormone] GO:1990834[response to odorant]
Metabolic proteins Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0005262[calcium channel activity] GO:0005516[calmodulin binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006816[calcium ion transport] GO:0006874[cellular calcium ion homeostasis] GO:0007602[phototransduction] GO:0007608[sensory perception of smell] GO:0008273[calcium, potassium:sodium antiporter activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009644[response to high light intensity] GO:0010469[regulation of signaling receptor activity] GO:0010628[positive regulation of gene expression] GO:0015293[symporter activity] GO:0015297[antiporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0021630[olfactory nerve maturation] GO:0031982[vesicle] GO:0035725[sodium ion transmembrane transport] GO:0036368[cone photoresponse recovery] GO:0042756[drinking behavior] GO:0048306[calcium-dependent protein binding] GO:0050849[negative regulation of calcium-mediated signaling] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0055074[calcium ion homeostasis] GO:0055085[transmembrane transport] GO:0070166[enamel mineralization] GO:0070588[calcium ion transmembrane transport] GO:0071486[cellular response to high light intensity] GO:0071805[potassium ion transmembrane transport] GO:0086009[membrane repolarization] GO:0097186[amelogenesis] GO:0098703[calcium ion import across plasma membrane] GO:0120199[cone photoreceptor outer segment] GO:1903998[regulation of eating behavior] GO:1990034[calcium ion export across plasma membrane] GO:1990680[response to melanocyte-stimulating hormone] GO:1990834[response to odorant]
Metabolic proteins Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level DeepTMHMM predicted membrane proteins
Show all
GO:0005262[calcium channel activity] GO:0005516[calmodulin binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006816[calcium ion transport] GO:0006874[cellular calcium ion homeostasis] GO:0007602[phototransduction] GO:0007608[sensory perception of smell] GO:0008273[calcium, potassium:sodium antiporter activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009644[response to high light intensity] GO:0010469[regulation of signaling receptor activity] GO:0015293[symporter activity] GO:0015297[antiporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0021630[olfactory nerve maturation] GO:0031982[vesicle] GO:0035725[sodium ion transmembrane transport] GO:0036368[cone photoresponse recovery] GO:0042756[drinking behavior] GO:0048306[calcium-dependent protein binding] GO:0050849[negative regulation of calcium-mediated signaling] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0055074[calcium ion homeostasis] GO:0055085[transmembrane transport] GO:0070166[enamel mineralization] GO:0070588[calcium ion transmembrane transport] GO:0071805[potassium ion transmembrane transport] GO:0086009[membrane repolarization] GO:0097186[amelogenesis] GO:0098703[calcium ion import across plasma membrane] GO:0120199[cone photoreceptor outer segment] GO:1903998[regulation of eating behavior] GO:1990034[calcium ion export across plasma membrane] GO:1990680[response to melanocyte-stimulating hormone] GO:1990834[response to odorant]