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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q24.1
Chromosome location (bp)
122838500 - 122872643
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo 1. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O95727 [Direct mapping] Cytotoxic and regulatory T-cell molecule
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001768[establishment of T cell polarity] GO:0001772[immunological synapse] GO:0001819[positive regulation of cytokine production] GO:0002250[adaptive immune response] GO:0002355[detection of tumor cell] GO:0002376[immune system process] GO:0002860[positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007157[heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037[cell recognition] GO:0016020[membrane] GO:0032729[positive regulation of interferon-gamma production] GO:0042802[identical protein binding] GO:0045580[regulation of T cell differentiation] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046007[negative regulation of activated T cell proliferation] GO:0050863[regulation of T cell activation] GO:0051606[detection of stimulus] GO:0097021[lymphocyte migration into lymphoid organs] GO:2001185[regulation of CD8-positive, alpha-beta T cell activation]
O95727 [Direct mapping] Cytotoxic and regulatory T-cell molecule
Show all
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001768[establishment of T cell polarity] GO:0001772[immunological synapse] GO:0001819[positive regulation of cytokine production] GO:0002250[adaptive immune response] GO:0002355[detection of tumor cell] GO:0002376[immune system process] GO:0002860[positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0005102[signaling receptor binding] GO:0005886[plasma membrane] GO:0007155[cell adhesion] GO:0007157[heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037[cell recognition] GO:0016020[membrane] GO:0032729[positive regulation of interferon-gamma production] GO:0045580[regulation of T cell differentiation] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046007[negative regulation of activated T cell proliferation] GO:0050863[regulation of T cell activation] GO:0051606[detection of stimulus] GO:0097021[lymphocyte migration into lymphoid organs] GO:2001185[regulation of CD8-positive, alpha-beta T cell activation]